Results 101 to 110 of about 37,425 (325)

The role of motor proteins in endosomal sorting [PDF]

, 2011
Microtubule motor proteins play key roles in the spatial organization of intracellular organelles as well as the transfer of material between them.
Hunt, Sylvie, Stephens, DJ
core   +2 more sources

Origin of eukaryotic-like Vps23 shapes an ancient functional interplay between ESCRT and ubiquitin system in Asgard archaea

Cell Reports
Summary: Functional interplay between the endosomal sorting complexes required for transport (ESCRT) and the ubiquitin system underlies the ubiquitin-dependent cargo-sorting pathway of the eukaryotic endomembrane system, yet its evolutionary origin ...
Zhongyi Lu, Siyu Zhang, Yang Liu, Runyue Xia, Meng Li   +4 more
doaj   +1 more source

ESCRT-0 is not required for ectopic Notch activation and tumor suppression in Drosophila.

PLoS ONE, 2014
Multivesicular endosome (MVE) sorting depends on proteins of the Endosomal Sorting Complex Required for Transport (ESCRT) family. These are organized in four complexes (ESCRT-0, -I, -II, -III) that act in a sequential fashion to deliver ubiquitylated ...
Emiliana Tognon, Nadine Wollscheid, Katia Cortese, Carlo Tacchetti, Thomas Vaccari   +4 more
doaj   +1 more source

Continuous nutrient supply culture strategy controls multivesicular endosomes pathway and anti-photo-aging miRNA cargo loading of extracellular vesicles

Journal of Tissue Engineering, 2023
Extracellular vesicle (EV) therapy recently had shown significant efficacy in various diseases. Serum starvation culture (SC) is one of the most widely used methods for collecting EVs.
Lihao Chen, Weihan Xie, Keke Wu, Yuan Meng, Yijun He, Jiawei Cai, Yuan Jiang, Qi Zhao, Yixi Yang, Minru Zhang, Manping Lu, Shaozhang Lin, Lin Liang, Zhiyong Zhang   +13 more
doaj   +1 more source

The ocular albinism type 1 (OA1) GPCR is ubiquitinated and its traffic requires endosomal sorting complex responsible for transport (ESCRT) function [PDF]

Proceedings of the National Academy of Sciences, 2011
The function of signaling receptors is tightly controlled by their intracellular trafficking. One major regulatory mechanism within the endo-lysosomal system required for receptor localization and down-regulation is protein modification by ubiquitination and downstream interactions with the endosomal sorting complex responsible for transport (ESCRT ...
Francesca, Giordano, Sabrina, Simoes, Graça, Raposo   +2 more
openaire   +2 more sources

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

The α-arrestin ARRDC3 mediates ALIX ubiquitination and G protein-coupled receptor lysosomal sorting. [PDF]

, 2015
The sorting of G protein-coupled receptors (GPCRs) to lysosomes is critical for proper signaling and cellular responses. We previously showed that the adaptor protein ALIX regulates lysosomal degradation of protease-activated receptor-1 (PAR1), a GPCR ...
Dores, Michael R, J Grimsey, Neil, Lin, Huilan, Mendez, Francisco, Trejo, JoAnn   +4 more
core   +1 more source

Hepatitis C Virus Proteins Interact with the Endosomal Sorting Complex Required for Transport (ESCRT) Machinery via Ubiquitination To Facilitate Viral Envelopment [PDF]

mBio, 2016
ABSTRACT Enveloped viruses commonly utilize late-domain motifs, sometimes cooperatively with ubiquitin, to hijack the e ndosomal s orting c omplex r equired for t ransport (ESCRT) machinery for budding at the ...
Barouch-Bentov, Rina, Neveu, Gregory, Xiao, Fei, Beer, Melanie, Bekerman, Elena, Schor, Stanford, Campbell, Joseph, Boonyaratanakornkit, Jim, Lindenbach, Brett, Lu, Albert, Jacob, Yves, Einav, Shirit   +11 more
openaire   +3 more sources

Expanding Chemical Space of Nucleic Acid Nanoparticles for Tunable Antiviral‐Like Immunomodulatory Responses and Potent Adjuvant Activity

Advanced Functional Materials, EarlyView.
We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj, Hannah S. Newton, Jian Wang, Laxmi Pandey, Yelixza I. Avilla, Phong Nguyen, Morgan Chandler, Justin Halman, Yasmine Radwan, Stephanie Smith, Elijah Edmondson, Simone Difilippantonio, Chelsea Sanders, Bao Tran, Yongmei Zhao, Shaojun Xie, Edward Cedrone, Barry W. Neun, Meni Wanunu, Nikolay V. Dokholyan, Marina A. Dobrovolskaia, Kirill A. Afonin   +21 more
wiley   +1 more source

Timing of ESCRT-III protein recruitment and membrane scission during HIV-1 assembly

eLife, 2018
The Endosomal Sorting Complexes Required for Transport III (ESCRT-III) proteins are critical for cellular membrane scission processes with topologies inverted relative to clathrin-mediated endocytosis.
Daniel S Johnson, Marina Bleck, Sanford M Simon   +2 more
doaj   +1 more source