Results 121 to 130 of about 37,425 (325)

From RNA to DNA: How Cargo Identity Reprograms Lipid Nanoparticle Architecture and Function

Advanced Healthcare Materials, EarlyView.
The evolution of lipid nanoparticles (LNPs) spans from RNA‐LNPs, used in mRNA vaccines, to DNA‐LNPs, ideal for gene therapies. Emerging bionano architectures, decorated with DNA and plasma proteins, pave the way for advanced DNA‐based therapies that are more stable, targeted, and customizable.
Erica Quagliarini, Daniela Pozzi, Giulio Caracciolo   +2 more
wiley   +1 more source

Amino acid substitution equivalent to human chorea-acanthocytosis I2771R in yeast Vps13 protein affects its binding to phosphatidylinositol 3-phosphate [PDF]

, 2017
The rare human disorder chorea-acanthocytosis (ChAc) is caused by mutations in hVPS13A gene. The hVps13A protein interacts with actin and regulates the level of phosphatidylinositol 4-phosphate (PI4P) in the membranes of neuronal cells.
Ayscough, K.R., Flis, K., Grynberg, M., Kaminska, J., Rzepnikowska, W., Urbanek, A., Zoladek, T.   +6 more
core   +2 more sources

ESCRT-III activation by parallel action of ESCRT-I/II and ESCRT-0/Bro1 during MVB biogenesis

eLife, 2016
The endosomal sorting complexes required for transport (ESCRT) pathway facilitates multiple fundamental membrane remodeling events. Previously, we determined X-ray crystal structures of ESCRT-III subunit Snf7, the yeast CHMP4 ortholog, in its active and ...
Shaogeng Tang, Nicholas J Buchkovich, W Mike Henne, Sudeep Banjade, Yun Jung Kim, Scott D Emr   +5 more
doaj   +1 more source

Engineering extracellular vesicles by three‐dimensional dynamic culture of human mesenchymal stem cells

Journal of Extracellular Vesicles, 2022
Human mesenchymal stem cell (hMSC) derived extracellular vesicles (EVs) have shown therapeutic potential in recent studies. However, the corresponding therapeutic components are largely unknown, and scale‐up production of hMSC EVs is a major challenge ...
Xuegang Yuan, Li Sun, Richard Jeske, Dingani Nkosi, Sara B. York, Yuan Liu, Samuel C. Grant, David G. Meckes Jr, Yan Li   +8 more
doaj   +1 more source

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

Specific recycling receptors are targeted to the immune synapse by the intraflagellar transport system [PDF]

, 2014
T cell activation requires sustained signaling at the immune synapse (IS), a specialized interface with the APC that assembles following TCR engagement by MHC-bound peptide.
Baldari, Batista, Bonello, Capitani, Das, Ehrlich, Finetti, Finetti, Follit, Follit, Fooksman, Gerdes, Gomez, Gorska, Hutagalung, Iezzi, Jin, Jékely, Keady, Kumar, Larghi, Li, Lim, Liu, Manders, Margadant, Maxfield, Mayle, Omori, Pampliega, Patino-Lopez, Patrussi, Pazour, Pazour, Pedersen, Pérez-Martínez, Qin, Salmerón, Schafer, Sedmak, Soares, Sönnichsen, Vardhana, Wood, Yudushkin   +44 more
core   +1 more source

A unique role for the host ESCRT proteins in replication of Tomato bushy stunt virus. [PDF]

PLoS Pathogens, 2009
Plus-stranded RNA viruses replicate in infected cells by assembling viral replicase complexes consisting of viral- and host-coded proteins. Previous genome-wide screens with Tomato bushy stunt tombusvirus (TBSV) in a yeast model host revealed the ...
Daniel Barajas, Yi Jiang, Peter D Nagy
doaj   +1 more source

Measles virus M protein-driven particle production does not involve the endosomal sorting complex required for transport (ESCRT) system

Journal of General Virology, 2010
Assembly and budding of enveloped RNA viruses rely on viral matrix (M) proteins and host proteins involved in sorting and vesiculation of cellular cargoes, such as the endosomal sorting complex required for transport (ESCRT). The measles virus (MV) M protein promotes virus-like particle (VLP) production, and we now show that it shares association with ...
Andreas, Salditt, Susanne, Koethe, Christine, Pohl, Harry, Harms, Larissa, Kolesnikova, Stephan, Becker, Sibylle, Schneider-Schaulies   +6 more
openaire   +2 more sources

Conformational Changes in the Endosomal Sorting Complex Required for the Transport III Subunit Ist1 Lead to Distinct Modes of ATPase Vps4 Regulation [PDF]

Journal of Biological Chemistry, 2015
Intralumenal vesicle formation of the multivesicular body is a critical step in the delivery of endocytic cargoes to the lysosome for degradation. Endosomal sorting complex required for transport III (ESCRT-III) subunits polymerize on endosomal membranes to facilitate membrane budding away from the cytoplasm to generate these intralumenal vesicles. The
Jason, Tan, Brian A, Davies, Johanna A, Payne, Linda M, Benson, David J, Katzmann   +4 more
openaire   +2 more sources

Multiphysics‐Driven Assembly of Biomimetic Vesicles

Advanced Materials, EarlyView.
Artificial extracellular vesicles, derived from cell membranes, are manufactured using a multiphysics‐integrated microfluidic platform that combines nanoknife membrane rupture, herringbone chaotic mixing, and acoustothermal modulation. This standardizable workflow enables the predictable control of vesicle formation and therapeutic loading, while ...
Timofei Solodko, Ian Gimino, Aastha Chandiwala, Bayan Alkotoub, Ali Bashiri Dezfouli, Heiko Reith, Asjad Bakhtiar, Rojda Hicsanmaz, Johann Brenner, Christoph J. O. Kaiser, Elena Belli, Shilpi Pandey, Samuel D. Rabkin, Kornelius Nielsch, Gabriele Multhoff, Oliver Hayden, Morteza Hasanzadeh Kafshgari   +16 more
wiley   +1 more source