Endosomal Sorting Complex Required for Transport (ESCRT) Complexes Induce Phase-separated Microdomains in Supported Lipid Bilayers* [PDF]
Journal of Biological Chemistry, 2012 Background: Endosomal sorting complex required for transport (ESCRT) complexes sort ubiquitinated membrane proteins into vesicles that bud away from the cytosol.
E. Bouřa +4 more
semanticscholar +3 more sources
Evidence that the endosomal sorting complex required for transport-II (ESCRT-II) is required for efficient human immunodeficiency virus-1 (HIV-1) production [PDF]
Retrovirology, 2015 BackgroundEgress of a number of different virus species from infected cells depends on proteins of the endosomal sorting complexes required for transport (ESCRT) pathway. HIV has also hijacked this system to bud viruses outward from the cell surface. How
B. Meng +4 more
semanticscholar +6 more sources
The Human Endosomal Sorting Complex Required for Transport (ESCRT-I) and Its Role in HIV-1 Budding*♦ [PDF]
Journal of Biological Chemistry, 2004 Efficient human immunodeficiency virus type 1 (HIV-1) budding requires an interaction between the PTAP late domain in the viral p6Gag protein and the cellular protein TSG101.
M. Stuchell +8 more
semanticscholar +3 more sources
Identification of Human VPS37C, a Component of Endosomal Sorting Complex Required for Transport-I Important for Viral Budding* [PDF]
Journal of Biological Chemistry, 2005 Endosomal sorting complex required for transport-I (ESCRT-I) is one of three defined protein complexes in the class E vacuolar protein sorting (VPS) pathway required for the sorting of ubiquitinated transmembrane proteins into internal vesicles of ...
S. Eastman +4 more
semanticscholar +4 more sources
Detection of the Endosomal Sorting Complex Required for Transport in Entamoeba histolytica and Characterization of the EhVps4 Protein [PDF]
Journal of Biomedicine and Biotechnology, 2010 Eukaryotic endocytosis involves multivesicular bodies formation, which is driven by endosomal sorting complexes required for transport (ESCRT). Here, we showed the presence and expression of homologous ESCRT genes in Entamoeba histolytica.
I. López-Reyes +7 more
semanticscholar +4 more sources
Endosomal-sorting complexes required for transport (ESCRT) pathway-dependent endosomal traffic regulates the localization of active Src at focal adhesions [PDF]
Proceedings of the National Academy of Sciences, 2010 Active Src localization at focal adhesions (FAs) is essential for cell migration. How this pool is linked mechanistically to the large pool of Src at late endosomes (LEs)/lysosomes (LY) is not well understood. Here, we used inducible Tsg101 gene deletion, TSG101 knockdown, and dominant-negative VPS4 expression to ...
Chun Tu +12 more
semanticscholar +3 more sources
Negative membrane curvature catalyzes nucleation of endosomal sorting complex required for transport (ESCRT)-III assembly [PDF]
Proceedings of the National Academy of Sciences, 2015 Significance The endosomal sorting complex required for transport (ESCRT) proteins remodel and sever membranes in a wide range of biology, including HIV budding. Electron microscopy has shown that ESCRT-III is often found in contact with concave (negatively curved) membrane surfaces. It has not been possible until now to determine whether the
Il-Hyung Lee +4 more
semanticscholar +5 more sources
The endosomal sorting complex required for transport (ESCRT) is required for the sensitivity of yeast cells to nickel ions in Saccharomyces cerevisiae. [PDF]
FEMS Yeast Research, 2016 Nickel is one of the toxic environment metal pollutants and is linked to various human diseases. In this study, through a functional genomics approach we have identified 16 nickel-sensitive and 22 nickel-tolerant diploid deletion mutants of budding yeast genes, many of which are novel players in the regulation of nickel homeostasis.
Chong Luo, C. Cao, Linghuo Jiang
semanticscholar +3 more sources
Arrestin-2 Interacts with the Endosomal Sorting Complex Required for Transport Machinery to Modulate Endosomal Sorting of CXCR4 [PDF]
Molecular Biology of the Cell, 2010 The chemokine receptor CXCR4, a G protein-coupled receptor, is targeted for lysosomal degradation via a ubiquitin-dependent mechanism that involves the endosomal sorting complex required for transport (ESCRT) machinery. We have reported recently that arrestin-2 also targets CXCR4 for lysosomal degradation; however, the molecular mechanisms by which ...
Malik, Rohit, Marchese, Adriano
openaire +2 more sources
The endosomal sorting complex required for transport repairs the membrane to delay cell death
Frontiers in Oncology, 2022 The endosomal sorting complex required for transport (ESCRT) machinery plays a key role in the repair of damaged plasma membranes with puncta form and removes pores from the plasma membrane in regulated cell death, apoptosis, necroptosis, pyroptosis, ferroptosis, and autophagy. ESCRT-I overexpression and ESCRT-III-associated charged multivesicular body
Ye Yang +5 more
openaire +3 more sources