Results 251 to 260 of about 37,425 (325)
Progress in RNA‐Targeted Therapeutics for Human Diseases
MedComm, Volume 7, Issue 2, February 2026.RNA‐targeted therapies are revolutionizing molecular medicine by transitioning from a “protein‐centric” focus to an “RNA‐regulatory network” approach. Leveraging RNA's diverse roles in gene regulation, signaling, and epigenetic modifications, advanced platforms such as ASOs, siRNA, miRNA, mRNA, aptamers, shRNA, and CRISPR/Cas systems are enabling ...
Wangzheqi Zhang +10 more
wiley +1 more source
Dual role of exosomes in neurodegenerative diseases: a molecular bridge between neuroinflammation and transmission of pathological proteins. [PDF]
Front NeurolAn W, Jin Z, Li Y.
europepmc +1 more source
Accelerate the Highly Efficient Development of mRNA Vaccines Through Advanced Computational Methods
MedComm, Volume 7, Issue 2, February 2026.This review explores the recent advancements in applying computational methods to optimize mRNA vaccines, with a primary focus on improvements in sequence design and delivery systems. ABSTRACT mRNA medicine is an emerging therapeutic approach that utilizes messenger RNA to synthesize functional proteins directly within target cells.
Ruichu Gu +5 more
wiley +1 more source
Centrosomal P4.1-associated protein is a novel regulator of ESCRT pathway function during endosome maturation. [PDF]
iScienceGudi R, Vasu C.
europepmc +1 more source
Small, Volume 22, Issue 8, 6 February 2026.Nano‐Cell Vesicle Technology (nCVTs) integrates cationic lipids with tumor‐homing cell membranes to achieve efficient intracellular transport of antisense oligonucleotides. The system enhances nuclear delivery, minimizes cytotoxicity, and suppresses tumor growth in vivo, establishing nCVTs as a versatile and biocompatible platform for next‐generation ...
Yi Hsuan Ou +11 more
wiley +1 more source
Vesicular transport in the autophagic route: RAB GTPases as pivotal regulators of autophagy. [PDF]
Biochem JAbba R, Colombo MI.
europepmc +1 more source
Vacuolar H+-ATPase Activity Is Required for Endocytic and Secretory Trafficking in Arabidopsis[W]
The Plant Cell Online, 2006 J. Dettmer +3 more
semanticscholar +1 more source
Small Methods, Volume 10, Issue 3, 9 February 2026.A new method to identify proteins involved in the uptake and intracellular trafficking of nanoparticles is presented. After nanoparticle uptake, cells are lysed and the organelles with nanoparticles are purified using fluorescence assisted cell sorting. Next, their composition is determined by proteomic analysis.
Hector Garcia Romeu, Anna Salvati
wiley +1 more source
Endosome maturation during ER stress relies on the ubiquitin-binding domain of histone deacetylase 6. [PDF]
Mol Biol CellPiscopo KM +4 more
europepmc +1 more source