Results 261 to 270 of about 37,425 (325)

Advances in the Development of Lipid Nanoparticles for mRNA Delivery

Small Structures, Volume 7, Issue 2, February 2026.
This review provides an integrated overview of mRNA–lipid nanoparticle (LNP) design, including lipid composition, scalable manufacturing, and structure–activity relationships. We highlight strategies for targeted delivery, physicochemical tuning, and high‐throughput screening such as DNA barcoding.
Xing Wang, Letao Xu, Zhenwei Lan, Yue Hui, Yun Liu, Guangze Yang, Chun‐Xia Zhao   +6 more
wiley   +1 more source

Hrs Controls Sorting of the Epithelial Na+ Channel between Endosomal Degradation and Recycling Pathways*

Journal of Biological Chemistry, 2010
Ruifeng Zhou, Rajesh Kabra, Diane R. Olson, R. Piper, P. Snyder   +4 more
semanticscholar   +1 more source

Bacterial Communities as Modulators of Innate Immune Signalling: An In Vitro Perspective on Toll‐Like Receptor Activation

Environmental Microbiology Reports, Volume 18, Issue 1, February 2026.
Bacterial contaminants in occupational environments may elicit an immune response. This study investigated the immune‐modulatory potential of bacterial communities using in vitro cell‐based assays and revealed distinctive bacterial species as drivers of TLR2 and TLR4 activation. The presented approach studied the role of bacterial species as modulators
Elke Eriksen, Pål Graff, Anani Komlavi Afanou   +2 more
wiley   +1 more source

Multifunctional Engineering of Exosomes for Precision Therapeutics: Strategies for Targeted Delivery, Barrier Evasion, and Clinical Translation. [PDF]

Pharm Res
Mendonca SR, Bangera PD, Keerikkadu M, Tippavajhala VK, Rathnanand M.   +4 more
europepmc   +1 more source

Synaptic Vesicle Glycoprotein 2A Suppresses Amyloidogenesis Beyond Its Synaptic Role: A Novel Mechanism Disrupting BACE1 Binding and Altering APP Localization

Aging Cell, Volume 25, Issue 2, February 2026.
Synaptic vesicle glycoprotein 2A, the newly identified APP‐binding protein, reduces amyloid‐β plaque deposition in Alzheimer's disease by suppressing the amyloidogenic pathway through inhibition of BACE1‐APP interaction and alteration of APP endosomal‐lysosomal localization.
Xiaoling Wang, Qian Zhang, Xiaomin Zhang, Jing Liu, Jingjing Zhang, Congcong Liu, Yuting Cui, Qiao Song, Yuli Hou, Yaqi Wang, Min Cao, Peichang Wang   +11 more
wiley   +1 more source

ESCRTing the RABs through conversion. [PDF]

Biochem Soc Trans
Solinger JA, Ott DP, Spang A.
europepmc   +1 more source

Research Progress of Exosome‐Derived microRNA in Alcohol Use Disorders: A Critical Review

Addiction Biology, Volume 31, Issue 2, February 2026.
Exosome‐derived microRNAs represent stable and mechanistically active mediators of alcohol‐induced multi‐organ injury. This review summarizes how chronic alcohol exposure reshapes exosomal miRNA cargo across the liver, immune system, and brain, highlighting key miRNAs with diagnostic value and therapeutic potential.
Bo Zhang, Ting ting Xie, Qiang Ma, Ya ping Jiang, Yu mei Wang   +4 more
wiley   +1 more source

Redefining the Limits of Nanodevices-Based Drug Delivery Systems: Extracellular Vesicles. [PDF]

Pharmaceutics
Díaz ML, Simón V, Benedini LA, Messina PV.   +3 more
europepmc   +1 more source

Non‐Coding RNAs in Breast Cancer Radioresistance: Mechanisms, Functional Roles and Translational Potentials

Cell Proliferation, Volume 59, Issue 2, February 2026.
Non‐coding RNAs (ncRNAs) regulate breast cancer radioresistance via cell cycle, DNA repair and tumour microenvironment pathways. Targeting ncRNAs (e.g., HOTAIR and miR‐155) with RNA‐based therapies (ASOs and CRISPR) shows promise but faces delivery challenges.
Xiaohui Zhao, Yuting Qiu, Jie Chen, Danni Wang, Zairui Wang, Shuang Ma, Yimin Liu, Guoying Liu, Zhuofei Bi   +8 more
wiley   +1 more source

Revisiting the role of Annexins in membrane trafficking. [PDF]

Cell Mol Life Sci
Grewal T, Gerke V, Nylandsted J, Rentero C, Enrich C.   +4 more
europepmc   +1 more source