Results 21 to 30 of about 37,425 (325)

The Sec1/Munc18 protein Vps45 regulates cellular levels of its SNARE binding partners Tlg2 and Snc2 in Saccharomyces cerevisiae [PDF]

, 2012
Intracellular membrane trafficking pathways must be tightly regulated to ensure proper functioning of all eukaryotic cells. Central to membrane trafficking is the formation of specific SNARE (soluble N-ethylmeleimide-sensitive factor attachment protein ...
A Bracher, BJ Nichols, CK Raymond, CM Carr, CR Cowles, CR Cowles, D Ungar, DP Nickerson, H Abeliovich, J Rahajeng, J Zouhar, JA McNew, JH Rothman, JS Bonifacino, JS Robinson, K Gengyo-Ando, KM Misura, Lindsay N. Carpp, LN Carpp, LN Carpp, Marion S. Struthers, MK Aalto, ML Furgason, MS Struthers, Nia J. Bryant, NJ Bryant, NJ Bryant, NJ Bryant, R Jahn, RC Piper, RC Piper, RC Piper, RD Gietz, Rebecca K. McCann, RF Toonen, RJ Harvey, S Braun, S Gurunathan, Scott G. Shanks, SF Nothwehr, SR Gerrard, SR Gerrard, T Wollert, TW Christianson, V Protopopov, Wanjin Hong, Y Wada, Y Wada   +47 more
core   +12 more sources

Septin6 and Septin7 GTP binding proteins regulate AP-3- and ESCRT-dependent multivesicular body biogenesis. [PDF]

PLoS ONE, 2014
Septins (SEPTs) form a family of GTP-binding proteins implicated in cytoskeleton and membrane organization, cell division and host/pathogen interactions. The precise function of many family members remains elusive.
Sofia Traikov, Christoph Stange, Thomas Wassmer, Perrine Paul-Gilloteaux, Jean Salamero, Graça Raposo, Bernard Hoflack   +6 more
doaj   +1 more source

The endosomal sorting complex required for transport machinery influences haem uptake and capsule elaboration in Cryptococcus neoformans [PDF]

Molecular Microbiology, 2015
SummaryIron availability is a key determinant of virulence in the pathogenic fungus Cryptococcus neoformans. Previous work revealed that the ESCRT (endosomal sorting complex required for transport) protein Vps23 functions in iron acquisition, capsule formation and virulence. Here, we further characterized the ESCRT machinery to demonstrate that defects
G. Hu, M. Caza, B. Cadieux, Erik Bakkeren, Eunsoo Do, W. Jung, J. Kronstad   +6 more
semanticscholar   +3 more sources

The endosomal sorting complex required for transport complex negatively regulates Erg6 degradation under specific glucose restriction conditions [PDF]

Traffic, 2020
Abstract Lipid droplets (LDs) are cytosolic fat storage organelles that play roles in lipid metabolism, trafficking and signaling. Breakdown of LDs in Saccharomyces cerevisiae is mainly achieved by lipolysis and lipophagy.
Ao Zhang, Ying Meng, Qunli Li, Yongheng Liang   +3 more
openaire   +2 more sources

Protein trafficking through the endosomal system prepares intracellular parasites for a home invasion [PDF]

, 2013
Toxoplasma (toxoplasmosis) and Plasmodium (malaria) use unique secretory organelles for migration, cell invasion, manipulation of host cell functions, and cell egress. In particular, the apical secretory micronemes and rhoptries of apicomplexan parasites
A Fomovska, AE Topolska, B Lige, B Shen, BF Kafsack, BJ Luft, C Lord, CA Hunter, Chetan E. Chitnis, Christian Slomianny, CY He, D Richard, DL Alexander, F Parussini, H El Hajj, HC Hoppe, HC Hoppe, I Mellman, J Schrevel, JB Dacks, JC Boothroyd, JE Rothman, JF Dubremetz, JM Harper, K Kremer, K Miranda, KA Joiner, KA Joiner, KM Hager, L Pelletier, L Sheiner, LH Bannister, LH Bannister, LM Kats, M Elias, M Tufet-Bayona, M Yang, Markus Meissner, ME Francia, MH Ngo, MH Ngo, MK Shaw, MS Breinich, MS Marks, NA Counihan, PJ Bradley, PJ Sloves, S Mogelsvang, SD Brydges, Stanislas Tomavo, VB Carruthers, Vern B. Carruthers, WM Henne, X Que, Z Dou   +54 more
core   +4 more sources

A Structural View on ESCRT-Mediated Abscission

Frontiers in Cell and Developmental Biology, 2020
The endosomal sorting complex required for transport (ESCRT) mediates cellular processes that are related to membrane remodeling, such as multivesicular body (MVB) formation, viral budding and cytokinesis.
Péter Horváth, Thomas Müller-Reichert
doaj   +1 more source

Insights into the function of ESCRT and its role in enveloped virus infection

Frontiers in Microbiology, 2023
The endosomal sorting complex required for transport (ESCRT) is an essential molecular machinery in eukaryotic cells that facilitates the invagination of endosomal membranes, leading to the formation of multivesicular bodies (MVBs).
Chunxuan Wang, Yu Chen, Shunlin Hu, Xiufan Liu, Xiufan Liu, Xiufan Liu   +5 more
doaj   +1 more source

What Is the Role of Giant Endosomal Sorting Complexes Required for Transport (ESCRT) Structures in T Cell Activation? [PDF]

Adv Biol (Weinh)
ABSTRACT Our lab recently discovered uniquely large (multiple micrometres) ring‐shaped cellular structures composed of endosomal sorting complexes required for transport (ESCRT) proteins. These structures are formed by tissue infiltrating fibroblasts, dendritic cells (DCs) and macrophages but only in specific culturing conditions ...
Psoma A, Stempels FC, de Boer R, van den Bogaart G.   +3 more
europepmc   +2 more sources

Membrane remodelling by a lipidated endosomal sorting complex required for transport-III chimera, in vitro [PDF]

Interface Focus, 2018
The complexity of eukaryotic cells is underscored by the compartmentalization of chemical signals by phospholipid membranes. A grand challenge of synthetic biology is building life from the ‘bottom-up’, for the purpose of generating systems simple enough to precisely interrogate biological pathways or for adapting biology to perform entirely novel ...
Marklew, CJ, Booth, A, Beales, PA, Ciani, B   +3 more
openaire   +6 more sources

Structural Insights into Endosomal Sorting Complex Required for Transport (ESCRT-I) Recognition of Ubiquitinated Proteins [PDF]

Journal of Biological Chemistry, 2004
The endosomal sorting complex required for transport (ESCRT-I) is a 350-kDa complex of three proteins, Vps23, Vps28, and Vps37. The N-terminal ubiquitin-conjugating enzyme E2 variant (UEV) domain of Vps23 is required for sorting ubiquitinated proteins into the internal vesicles of multivesicular bodies.
Hsiangling, Teo, Dmitry B, Veprintsev, Roger L, Williams   +2 more
openaire   +2 more sources