Results 31 to 40 of about 37,425 (325)

The ESCRT-III isoforms CHMP2A and CHMP2B display different effects on membranes upon polymerization

BMC Biology, 2021
Background ESCRT-III proteins are involved in many membrane remodeling processes including multivesicular body biogenesis as first discovered in yeast.
Maryam Alqabandi, Nicola de Franceschi, Sourav Maity, Nolwenn Miguet, Marta Bally, Wouter H. Roos, Winfried Weissenhorn, Patricia Bassereau, Stéphanie Mangenot   +8 more
doaj   +1 more source

Lipid droplets in stress protection: distinct mechanisms of lipid droplet microautophagy

Autophagy Reports, 2022
Lipid droplets (LDs) are organelles that function as sites for lipid storage. LDs have also been implicated in the cellular response to proteotoxic or lipotoxic stress as sites for sequestering dysfunctional or excess proteins or lipids, and targeting ...
Pin-Chao Liao, Liza A. Pon
doaj   +1 more source

Endosomal sorting complex required for transport proteins in cancer pathogenesis, vesicular transport, and non‐endosomal functions

Cancer Science, 2008
Endosomal sorting complex required for transport (ESCRT) proteins form a multicomplex sorting machinery that controls multivesicular body (MVB) formation and the sorting of ubiquitinated membrane proteins to the endosomes. Being sorted to the MVB generally results in the lysosome‐dependent degradation of cell‐surface receptors, and defects in this ...
Nobuyuki, Tanaka, Masanao, Kyuuma, Kazuo, Sugamura   +2 more
openaire   +2 more sources

HRS mediates tumor immune evasion by regulating proteostasis-associated interferon pathway activation

Cell Reports, 2023
Summary: By sorting receptor tyrosine kinases into endolysosomes, the endosomal sorting complexes required for transport (ESCRTs) are thought to attenuate oncogenic signaling in tumor cells. Paradoxically, ESCRT members are upregulated in tumors.
Wei Zhang, Jiegang Yang, Beike Wang, Youtao Lu, Jingbo Yang, Wenqun Zhong, Ziyan Yu, Zhiyuan Qin, Bolin Xiao, Kuiming Wang, Yi Y. Ma, Ravi Amaravadi, Meenhard Herlyn, Junhyong Kim, Xiaowei Xu, Wei Guo   +15 more
doaj   +1 more source

Syntaxin 16 is a master recruitment factor for cytokinesis [PDF]

, 2013
Recently it was shown that both recycling endosome and endosomal sorting complex required for transport (ESCRT) components are required for cytokinesis, in which they are believed to act in a sequential manner to bring about secondary ingression and ...
Alexandra Kaupisch, Barr FA, Bastos RN, Bissig C, Blum R, Carlton J, Carlton JG, Carr CM, Chen X.-W., Chesneau L, Choudhury A, Dambournet D, Dulubova I, Elia N, Fededa JP, Fielding AB, Fielding AB, Francis A. Barr, Glotzer M, Goss JW, Gromley A, Guizetti J, Gwyn W. Gould, Hong W, Hélia Neto, Jung JJ, Lee HH, Louise L. Collins, Low SH, Manickam V, Mondal G, Munson M, Neto H, Prekeris R, Proctor KM, Rannou Y, Riggs KA, Scales SJ, Schiel JA, Schiel JA, Schiel JA, Schiel JA, Simon GC, Simonsen A, Struthers MS, Tellam JT, TerBush DR, Xu H, Zhang XM   +48 more
core   +2 more sources

Traffic into silence: endomembranes and post-transcriptional RNA silencing. [PDF]

, 2014
microRNAs (miRNAs) and small interfering RNAs (siRNAs) are small RNAs that repress gene expression at the post-transcriptional level in plants and animals. Small RNAs guide Argonaute-containing RNA-induced silencing complexes to target RNAs in a sequence-
Chen, Xuemei, Kim, Yun Ju, Maizel, Alexis   +2 more
core   +3 more sources

In vitro reconstitution of the ordered assembly of the endosomal sorting complex required for transport at membrane-bound HIV-1 Gag clusters [PDF]

Proceedings of the National Academy of Sciences, 2012
Most membrane-enveloped viruses depend on host proteins of the endosomal sorting complex required for transport (ESCRT) machinery for their release. HIV-1 is the prototypic ESCRT-dependent virus. The direct interactions between HIV-1 and the early ESCRT factors TSG101 and ALIX have been mapped in detail.
L. Carlson, J. Hurley
semanticscholar   +3 more sources

Dynamics of endosomal sorting complex required for transport (ESCRT) machinery during cytokinesis and its role in abscission [PDF]

Proceedings of the National Academy of Sciences, 2011
The final stage of cytokinesis is abscission, the cutting of the narrow membrane bridge connecting two daughter cells. The endosomal sorting complex required for transport (ESCRT) machinery is required for cytokinesis, and ESCRT-III has membrane scission activity in vitro, but the role of ESCRTs in abscission has been undefined. Here, we use structured
Natalie, Elia, Rachid, Sougrat, Tighe A, Spurlin, James H, Hurley, Jennifer, Lippincott-Schwartz   +4 more
openaire   +2 more sources

The Calpain-7 protease functions together with the ESCRT-III protein IST1 within the midbody to regulate the timing and completion of abscission

eLife, 2023
The Endosomal Sorting Complexes Required for Transport (ESCRT) machinery mediates the membrane fission step that completes cytokinetic abscission and separates dividing cells.
Elliott L Paine, Jack J Skalicky, Frank G Whitby, Douglas R Mackay, Katharine S Ullman, Christopher P Hill, Wesley I Sundquist   +6 more
doaj   +1 more source

The chromosomal passenger complex controls the function of endosomal sorting complex required for transport-III Snf7 proteins during cytokinesis [PDF]

Open Biology, 2012
Summary Cytokinesis controls the proper segregation of nuclear and cytoplasmic materials at the end of cell division. The chromosomal passenger complex (CPC) has been proposed to monitor the final separation of the two daughter cells at the end of cytokinesis in order to prevent cell abscission in the presence of DNA at the ...
Capalbo, Luisa, Montembault, Emilie, Takeda, Tetsuya, Bassi, Zuni, Glover, David, d'Avino, Pier Paolo   +5 more
openaire   +5 more sources