Results 41 to 50 of about 37,425 (325)
Structural basis of HIV-1 Vpu-mediated BST2 antagonism via hijacking of the clathrin adaptor protein complex 1. [PDF]
, 2014 BST2/tetherin, an antiviral restriction factor, inhibits the release of enveloped viruses from the cell surface. Human immunodeficiency virus-1 (HIV-1) antagonizes BST2 through viral protein u (Vpu), which downregulates BST2 from the cell surface.
Guatelli, John +7 more
core +1 more source
Alix serves as an adaptor that allows human parainfluenza virus type 1 to interact with the host cell ESCRT system. [PDF]
PLoS ONE, 2013 The cellular ESCRT (endosomal sorting complex required for transport) system functions in cargo-sorting, in the formation of intraluminal vesicles that comprise multivesicular bodies (MVB), and in cytokinesis, and this system can be hijacked by a number ...
Jim Boonyaratanakornkit +3 more
doaj +1 more source
Toxoplasma gondii Syntaxin 6 is required for vesicular transport between endosomal-like compartments and the Golgi Complex [PDF]
, 2013 Apicomplexans are obligate intracellular parasites that invade the host cell in an active process that relies on unique secretory organelles (micronemes, rhoptries and dense granules) localized at the apical tip of these highly polarized eukaryotes ...
Clucas, Caroline +4 more
core +1 more source
An autophagy assay reveals the ESCRT-III component CHMP2A as a regulator of phagophore closure
Nature Communications, 2018 During autophagy, phagophores elongate to form double-membrane vesicles but the mechanism behind their closure is unknown. Here, the authors develop an autophagy assay and find a role for the endosomal sorting complexes required for transport component ...
Yoshinori Takahashi +14 more
doaj +1 more source
Journal of Cell Science, 2021 His domain protein tyrosine phosphatase (HD-PTP; also known as PTPN23) collaborates with endosomal sorting complexes required for transport (ESCRTs) to sort endosomal cargo into intralumenal vesicles, forming the multivesicular body (MVB).
Gabrielle T. Parkinson +4 more
semanticscholar +1 more source
REGULATION OF Fc RECEPTOR ENDOCYTIC TRAFFICKING BY UBIQUITINATION
Frontiers in Immunology, 2014 Most immune cells, particularly phagocytes, express various receptors for the Fc-portion of the different immunoglobulin isotypes (Fc receptors, FcRs).
Rosa eMolfetta +5 more
doaj +1 more source
The multifaceted interactions between pathogens and host ESCRT machinery.
PLoS Pathogens, 2023 The Endosomal Sorting Complex Required for Transport (ESCRT) machinery consists of multiple protein complexes that coordinate vesicle budding away from the host cytosol.
Yolanda Rivera-Cuevas, Vern B Carruthers
doaj +1 more source
HFE and transferrin directly compete for transferrin receptor in solution and at the cell surface [PDF]
, 2004 Transferrin receptor (TfR) is a dimeric cell surface protein that binds both the serum iron transport protein transferrin (Fe-Tf) and HFE, the protein mutated in patients with the iron overload disorder hereditary hemochromatosis.
Bjorkman, Pamela J. +1 more
core +2 more sources
PLoS Biology, 2021 The lysosome is an essential organelle to recycle cellular materials and maintain nutrient homeostasis, but the mechanism to down-regulate its membrane proteins is poorly understood.
Weichao Zhang +9 more
doaj +1 more source
Journal of Neuroscience, 2006 Alix/apoptosis-linked gene-2 (ALG-2)-interacting protein X is an adaptor protein involved in the regulation of the endolysosomal system through binding to endophilins and to endosomal sorting complexes required for transport (ESCRT) proteins, TSG101 and ...
A. Mahul-Mellier +4 more
semanticscholar +1 more source