Results 221 to 230 of about 138,036 (346)

Where and how do mammalian cells shape autophagosomes? [PDF]

J Biol Chem
Puri C, Rubinsztein DC.
europepmc   +1 more source

Transcriptomic signatures reveal systemic adaptations and immune modulation in response to training and competitive racing in horses

Equine Veterinary Journal, EarlyView.
Abstract Background The molecular mechanisms underlying adaptation to physical exertion and racing stress in horses remain incompletely understood. Peripheral blood transcriptomics offers a minimally invasive method to monitor systemic responses to exercise and identify biomarkers of adaptation or overload. Objectives To evaluate transcriptomic changes
Izabela Dąbrowska, Jowita Grzędzicka‐Agko, Paula Kiełbik, Michał Trela, Olga Witkowska‐Piłaszewicz   +4 more
wiley   +1 more source

Impaired BDNF-TrkB trafficking and signalling in Down syndrome basal forebrain neurons. [PDF]

Cell Death Dis
Blackburn E, Birsa N, Lopes AT, Fisher EMC, Lazo OM, Schiavo G.   +5 more
europepmc   +1 more source

Altered gene expression in the liver and small intestine of horses with equine neuroaxonal dystrophy

Equine Veterinary Journal, EarlyView.
Abstract Background Equine neuroaxonal dystrophy/degenerative myeloencephalopathy (eNAD/EDM) is the second most common diagnosis of spinal ataxia in horses in the United States. The disease develops due to a combination of vitamin E deficiency and an unknown genetic risk factor(s), and there currently is no effective treatment.
Stephanie Ryan, Blythe Durbin‐Johnson, Kevin Woolard, Andrew D. Miller, Carrie J. Finno   +4 more
wiley   +1 more source

Light-based modulation of astrocytic calcium for regulation of organelle dynamics and morphogenesis. [PDF]

J Cell Biol
Yang L, Björklund M, Yi C, Chen S, Hong Z.   +4 more
europepmc   +1 more source

Enhancing Optogenetics‐Based Cancer Therapy Via Nanotechnology

Exploration, EarlyView.
Nanotechnology enhances optogenetics‐based cancer therapy through improved delivery systems and non‐invasive optical regulation. It further enables precise and programmable control of optogenetic living therapeutics for localized antitumor responses.
Honggang Shen, Wenzhe Yi, Rongzhang Li, Shuangshuang Hu, Xindi Qian, Dan Yan, Qian Zou, Guanru Wang, Yaping Li   +8 more
wiley   +1 more source

Visualizing suborganellar lipid distribution using correlative light and electron microscopy. [PDF]

Nat Cell Biol
Lennartz HM, Khan S, Leng W, Böhlig K, Fabig G, Kieswald Y, Elsner F, Scher N, Wilsch-Bräuninger M, Avinoam O, Nadler A.   +10 more
europepmc   +1 more source

Mapping Epidermal Growth Factor Receptor-1 Sorting Domains in Endosomes with a Calibrated Three-Dimensional Expansion Microscopy Toolkit. [PDF]

ACS Nano
Shakespeare T, Seehra RS, Flores Rodriguez N, Atuanya N, Sheard TMD, Köhler R, Bose D, Wunderley L, Woodman P, Ciani B, Jayasinghe I.   +10 more
europepmc   +1 more source

Pharmacological effects of gastrodin: Insight into neurological diseases and mechanism in ferroptosis and pyroptosis

Ibrain, Volume 11, Issue 1, Page 74-83, Spring 2025.
Pharmacological effects of gastrodin include prevention and treatment of cognitive decline and reperfusion injuries, anticonvulsion, antiepilepsy, antidepressants, and analgesia, which are related to antiferroptosis and antipyroptosis. Abstract Gastrodin, as an effective monomer of gastrodia elata, plays a significant role in anti‐inflammatory ...
Xue Zheng, Jing Li, Zhao‐Qiong Zhu
wiley   +1 more source

Impact of ASO conjugation and receptor binding affinity on intracellular transport of mono- and bispecific TfR- and CD98-Brainshuttle^TM variants. [PDF]

MAbs
Sela T, Wirth T, Sommer A, Larraillet V, Butzer J, Lohmann S, Wittmann P, Klein C, Knoetgen H, Villasenor R, Indlekofer A, Hofer K, Schumacher F, Niewöhner J.   +13 more
europepmc   +1 more source