Results 241 to 250 of about 138,036 (346)

Binuclear Copper‐Dependent Oxidative Enzymes Involved in Fungal Natural Product Modifications

Journal of the Chinese Chemical Society, EarlyView.
This article summarizes recent biochemical characterizations of a new enzyme family named by the authors as binuclear copper‐dependent oxidative enzymes (BiNCOs). Found in fungal natural product biosynthesis, BiNCOs catalyze diverse CH functionalization reactions, including C(sp3)H halogenation, C(sp3)H hydroxylation, C(sp3)O macrocyclization, and ...
Chen‐Yu Chiang, Masao Ohashi, Yi Tang
wiley   +1 more source

Cell swelling and upright mounting-based imaging for high-resolution visualization of intracellular trafficking across the BBB using conventional confocal microscopy. [PDF]

Drug Deliv
Oh DH, Kang JH, Lee OH, Ko YT.
europepmc   +1 more source

Molecular dynamics simulations of oleuropein diffusion in chitosan‐based nanoparticles

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND This study explores the diffusion mechanisms of oleuropein (OLE), a promising polyphenolic compound, within chitosan‐based nanoparticles using molecular dynamics simulations. Chitosan nanoparticles serve as drug delivery carriers, leveraging biocompatibility and tunable release properties influenced by environmental factors such as ...
Bernardino Tirri, Andrea Lorenzoni, Francesco Mercuri, Pietro Calandra   +3 more
wiley   +1 more source

Opportunities and challenges for cancer immunotherapy based on antigen cross-presentation. [PDF]

Ann Med
Liu P, Zhou Z, Su X, Xu Y, Li J.
europepmc   +1 more source

Beyond Skin and Eyes: The Medical and Social Burden of Oculocutaneous Albinism in Africa: A Narrative Review

JEADV Clinical Practice, EarlyView.
ABSTRACT Oculocutaneous albinism (OCA) is a genetic disorder found worldwide, but its impact is particularly pronounced in the African continent. This results from both a higher prevalence and the persistent myths and superstitions surrounding the condition in many African communities.
Rebecca Donadoni, Niccolò Capurro, Alessandro Svizzero, Valeria Brazzelli   +3 more
wiley   +1 more source

Interference of Large Clostridial Glucosyltransferases with the Endolysosomal Pathway: Toxin-Induced Imbalance of Early Endosomes, Functional Lysosomes and Autophagosomes. [PDF]

Toxins (Basel)
Langejürgen A, Schmidt G, Unsöld L, Tatge H, Oyson E, Gerhard R.   +5 more
europepmc   +1 more source

miR‐9 Restricts Insulin Secretion by Targeting Rab34, Which Mediates Lysosomal Degradation of Proinsulin

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Insulin secretion is a complex, vesicular transport process. Rab34 is a key regulator of intracellular vesicle transport; however, its role in insulin secretion has not yet been reported. miRNA‐9 is vital for the development and progression of the diagnosis and treatment of type 2 diabetes. This study aimed to investigate whether miR‐9 targets
Zhen‐Zhen Guo, Ao‐Ying Li, Ting‐Ting Xiang, Zu‐Hao Zhang, Ao Deng, Yang Han   +5 more
wiley   +1 more source

Endosome-phagophore linking assemblies for the degradation of membrane/extracellular proteins. [PDF]

Nat Commun
Wang P, Sun H, An P, Tang P, Liu Q, Tang Z, Lv T, Ruan J, Zhen X, Han L.   +9 more
europepmc   +1 more source

Tracking Genetic Parkinson's Disease with Molecular Imaging: A Systematic Review

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Parkinson's disease (PD) is a worldwide, complex neurodegenerative disorder influenced by both genetic and environmental factors. Around 15–20% of PD cases are linked to genetic mutations, providing insights into the disease's pathogenesis.
Chiara Meneghini, Luca Gallo, Arianna Sala, Enza Maria Valente, Micol Avenali, Silvia Paola Caminiti   +5 more
wiley   +1 more source

Stress-induced proteome remodeling at the Golgi-endosome interface. [PDF]

J Cell Sci
Simon G, Abraham Pol S, Dendusic M, Schulze N, Stupia S, Koci M, Buzuk L, Thier B, Steinbach P, Trinh H, Schillinger J, Ninck S, Kaschani F, Kaiser M, Ehrmann M, Paschen A, Hellerschmied D.   +16 more
europepmc   +1 more source