Results 271 to 280 of about 138,036 (346)

Centrosomal P4.1-associated protein is a novel regulator of ESCRT pathway function during endosome maturation. [PDF]

iScience
Gudi R, Vasu C.
europepmc   +1 more source

Rounded Monodisperse Fluorescent Nanodiamonds

Small, EarlyView.
Nanodiamond (ND) shape control using rapid molten‐nitrate etching is studied as a scale‐up method for monodispersed rounded particles. Optimal etching condition (567°C for 6 min) yields NDs with atomically stepped surfaces and reduced sp2 content. Compared to angular control, rounded NDs exhibit an increased proportion of luminescent particles (66% vs.
Helena Raabova, Ivan Rehor, Jan Havlik, Stuart Turner, Jan Stursa, Vladimira Petrakova, Michal Gulka, Petr Cigler   +7 more
wiley   +1 more source

Rethinking the Yeast Endomembrane System. [PDF]

Subcell Biochem
Glick BS.
europepmc   +1 more source

Active pH Modulation by Proton Channel‐Peptide Nucleic Acid Complex for Effective siRNA Endosomal Escape

Small, EarlyView.
A bioinspired siRNA nanocarrier is engineered by integrating an influenza A M2 proton channel with siRNA through a peptide nucleic acid linker on liposome surfaces. Active proton transport amplifies osmotic stress within endosomes, triggering membrane rupture and cytosolic release.
Seongmin Ga, Nam Hyeong Kim, Si Yeon Ryu, Kyeonghyun Kim, Eun Sung Kang, Hayeon Bae, Seungmin Ryu, Suhyeon Kim, Yeontae Jang, Bok‐Soo Lee, Jiyoung Nam, Minah Suh, Jaecheol Lee, Seung‐gu Kang, Jaekyung Hyun, Huong T. Kratochvil, Yong Ho Kim   +16 more
wiley   +1 more source

Smart event-triggered MINFLUX microscopy to catch and follow rare events. [PDF]

Nat Commun
Alvelid J, Koerfer A, Eggeling C.
europepmc   +1 more source

A Ferrous‐Supply‐Regenerating Lipid Nanoparticle Integrating RNAi Induces Ferroptosis for Cancer Therapy

Small, EarlyView.
ABSTRACT Targeting iron‐dependent ferroptosis with siRNA has emerged as a promising strategy for cancer treatment. The concept of ferrous‐supply regeneration, inspired by electro‐Fenton technology, has also gained interest as a non‐apoptotic approach to induce ferroptosis.
Dun Hu, Yun‐Hua Xu, Dan Peng, Qi Tan, Jun‐Lin Jiang, Sheng‐Dan Nie, Shan Wang   +6 more
wiley   +1 more source

Conformational biosensors delineate endosomal G protein regulation by GPCRs. [PDF]

Nat Commun
Wysolmerski B, Fisher NM, Dates AN, Inoue A, Blythe EE, von Zastrow M.   +5 more
europepmc   +1 more source

Stimuli‐responsive nanostructured hydrogen sulfide donors for enhanced cancer treatments

Smart Molecules, EarlyView.
Three typical kinds of stimuli‐responsive nanostructured hydrogen sulfide (H2S) donors are reviewed. The nanostructures ensure precise delivery of H2S to the lesion site and regulate the release behavior. The H2S‐based gas therapy has been used to synergize with other cancer treatment modalities, achieving enhanced efficacy while reducing side effects.
Yuxuan Lyu, Jiaxuan Zhu, Lei Lei, Qingyang Zhong, Zhao Li, Caihong Lei, Fan Rong, Yin Wang   +7 more
wiley   +1 more source

PIKI-1, a class II PI 3-kinase, functions in endocytic trafficking. [PDF]

PLoS Genet
Reimann GR, Edeen PT, Conquest S, Grant BD, Fay DS.   +4 more
europepmc   +1 more source

Endocytosis‐independent cytosolic entry of messenger RNA via fluorous bilayer zippering attenuating Toll‐like receptor signaling and enables ischemic tissue salvage

Smart Molecules, EarlyView.
The present study establishes a paradigm shift in synthetic mRNA delivery through the convergence of three orthogonal chemistries—perfluoro‐acylation, bio‐orthogonal click cross‐linking, and disulfide reduction—within a single, modular polymer architecture. Abstract A fundamental constraint of conventional messenger RNA (mRNA) delivery systems is their
Yue Wang, Haitao Xie, Guoqing Xiang, Yanhua Li, Changgui Tong, Hongyan Cui, Qixian Chen, Haidong Li, Yan Zhao   +8 more
wiley   +1 more source