Results 201 to 210 of about 107,252 (310)

miR‐9 Restricts Insulin Secretion by Targeting Rab34, Which Mediates Lysosomal Degradation of Proinsulin

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Insulin secretion is a complex, vesicular transport process. Rab34 is a key regulator of intracellular vesicle transport; however, its role in insulin secretion has not yet been reported. miRNA‐9 is vital for the development and progression of the diagnosis and treatment of type 2 diabetes. This study aimed to investigate whether miR‐9 targets
Zhen‐Zhen Guo, Ao‐Ying Li, Ting‐Ting Xiang, Zu‐Hao Zhang, Ao Deng, Yang Han   +5 more
wiley   +1 more source

PIKfyve is required for efficient phagosomal Rab7 acquisition and the delivery and fusion of early macropinosomes to phagosomes. [PDF]

J Cell Sci
Vines JH, Buckley CM, Willson I, Stark DS, King JS.   +4 more
europepmc   +1 more source

Poly(2‐Oxazoline)‐Based Polyphotoacids: Synthesis, Solution Behavior, and Cellular Uptake of Multi‐Responsive Intracellular Transporters

Macromolecular Rapid Communications, EarlyView.
The ability of photoacids to increase their acidity in response to light irradiation (excited state proton transfer, ESPT) makes them attractive building blocks for the design of stimuli‐responsive copolymers. In this contribution, we present highly biocompatible polyphotoacids based on poly(2‐oxazoline)s bearing 1‐hydroxypyrene units. Low cytotoxicity,
Leonid I. Kaberov, Amod Godbole, Laura Klement, Sreevalsan Achikkulathu, Avinash Chettri, Benjamin Dietzek‐Ivanšić, Carsten Hoffmann, Felix H. Schacher   +7 more
wiley   +1 more source

GTPase Rab11b and effector Rab11-FIP2 promote NLRP3 stability during inflammasome priming. [PDF]

EMBO J
Gravastrand CS, Yurchenko M, Kristensen S, Skjesol A, Chen C, Ullmann S, Iqbal Z, Dahlen KR, Rasheed K, Nonstad U, Ryan L, Espevik T, Husebye H.   +12 more
europepmc   +1 more source

Aliphatic Poly(Carbonate)s with Acid Responsive Release Mechanisms for Micellar Anti‐Tumor Drug Delivery

Macromolecular Rapid Communications, EarlyView.
Micellar systems based on biodegradable aliphatic polycarbonates and acid‐responsive triggers enhance drug solubility, stability, and tumor‐selective release. This review covers micelles with acid‐cleavable drug linkages and those that disassemble via acid‐sensitive functionalities.
Adrian V. Hauck, Lutz Nuhn
wiley   +1 more source

Oxidative stress induced by DMSA-IONPs impairs breast cancer cell migration and paracrine cell communication. [PDF]

J Nanobiotechnology
Daviu N, Graciano-Casero C, Barber DF.
europepmc   +1 more source

Advances in GPCRs Associated With Wnt Signaling Within the Auditory System

Medicine Bulletin, EarlyView.
ABSTRACT G protein‐coupled receptors (GPCRs) that interact with the Wnt signaling pathway are pivotal for auditory system homeostasis, as they orchestrate inner ear development, hair cell (HC) regeneration, and hearing preservation. Frizzled (FZD) receptors, the core Wnt‐related GPCRs, bind Wnt ligands and co‐receptors (e.g., LRP5/6) to activate both ...
Liang Wang, Changling Xu, Jiangang Fan, Renjie Chai   +3 more
wiley   +1 more source

The Roles of Alix and VPS4A in Autophagy and Endosomal Pathways and Their Relation to HBV Replication. [PDF]

FASEB J
Li J, Kemper T, Tong S, Wang X, Lin Y, Lu M.   +5 more
europepmc   +1 more source

Tracking Genetic Parkinson's Disease with Molecular Imaging: A Systematic Review

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Parkinson's disease (PD) is a worldwide, complex neurodegenerative disorder influenced by both genetic and environmental factors. Around 15–20% of PD cases are linked to genetic mutations, providing insights into the disease's pathogenesis.
Chiara Meneghini, Luca Gallo, Arianna Sala, Enza Maria Valente, Micol Avenali, Silvia Paola Caminiti   +5 more
wiley   +1 more source

Proximity Labeling Reveals How Lrp2 Interacts with the Endocytic Machine. [PDF]

J Proteome Res
Shen TH, Beenken A, Erdjument-Bromage H, Weisz OA, Ghotra A, Kushner JS, Sturley RE, Kahn A, Kronenberg L, Rahmani G, Nesanir K, High FA, Donahoe PK, Barasch J, Neubert TA.   +14 more
europepmc   +1 more source