Results 201 to 210 of about 113,399 (298)

Late Endosome Transport by RILP-RAB7A Promotes Dendrite Arborization Independently of Degradation. [PDF]

J Neurosci
Yap CC, Digilio L, McMahon LP, Mulligan RJ, Witteveen IF, Winckler B.   +5 more
europepmc   +1 more source

Engineering mRNA‐LNP Medicines for the Ageing Brain: Opportunities and Challenges for Neurodegenerative Diseases

Exploration, EarlyView.
This review highlights recent advances in engineering messenger RNA (mRNA)‐lipid nanoparticles (LNPs) to cross the ageing blood–brain barrier and target neurodegenerative diseases. It outlines design principles, delivery routes, and translational challenges, charting a roadmap towards clinical application of mRNA‐LNP therapeutics for neurodegenerative ...
Abdel Ali Belaidi, Denzil L. Furtado, Francesca Alves, Rebecca M. Nisbet, Scott Ayton, Ashley I. Bush   +5 more
wiley   +1 more source

Endosomal TPC1-mediated Ca²⁺ nanodomains regulate transferrin receptor trafficking and iron homeostasis. [PDF]

Proc Natl Acad Sci U S A
Burton WJ, Lin A, Morgan AJ, Davis LC, Chen CC, Galione A.   +5 more
europepmc   +1 more source

Correction for Formation of alpha-synuclein Lewy neurite-like aggregates in axons impedes the transport of distinct endosomes. [PDF]

Mol Biol Cell
europepmc   +1 more source

Oncogenic Gα signaling requires AP-3-dependent recruitment to the endolysosomal compartment. [PDF]

Proc Natl Acad Sci U S A
Shettigar M, Moulière S, Isenegger L, DeVine AL, Gstalder C, Koduri V, Doench JG, Ksander B, Garcia-Marcos M, Kaelin WG, Haq R.   +10 more
europepmc   +1 more source

Pharmacological effects of gastrodin: Insight into neurological diseases and mechanism in ferroptosis and pyroptosis

Ibrain, Volume 11, Issue 1, Page 74-83, Spring 2025.
Pharmacological effects of gastrodin include prevention and treatment of cognitive decline and reperfusion injuries, anticonvulsion, antiepilepsy, antidepressants, and analgesia, which are related to antiferroptosis and antipyroptosis. Abstract Gastrodin, as an effective monomer of gastrodia elata, plays a significant role in anti‐inflammatory ...
Xue Zheng, Jing Li, Zhao‐Qiong Zhu
wiley   +1 more source

Huntingtin polyglutamine expansions misdirect axonal transport by perturbing motor and adaptor recruitment. [PDF]

iScience
Prowse ENP, Turkalj BA, Sébastien M, Gursu L, Beaudet D, Feng J, Zhou C, McBride HM, Brouhard GJ, Pouladi MA, Hendricks AG.   +10 more
europepmc   +1 more source

Cysteine Peptidases in Antitumor Immunity: Unraveling Antigen‐Presenting Cell Regulation and Therapeutic Potential

iMetaMed, EarlyView.
This review systematically summarizes the central role of cysteine peptidases in modulating antigen‐presenting cell (APC) function and antitumor immune responses, highlighting their critical significance in overcoming tumor immune evasion. Current research has established that cysteine peptidase subtypes, including cathepsins B, S, L, and X, exert ...
Yimao Wu, Xiaoyan Chen, Zichang Chen, Yalun Liang, Gokhan Zengin, Qian Zhang, Wenlong Sun, Meng‐Yao Li   +7 more
wiley   +1 more source

Endosome maturation is orchestrated by inside-out proton signaling through a Na⁺/H⁺ exchanger and pH-dependent Rab GTPase cycling. [PDF]

Nat Commun
Lee Y, Ouyang Q, Ma L, Fleishman M, Riaz HA, Schmidt M, Dupree JL, Mondal A, Mohanty P, Mittal J, Beckstein O, Lambright DG, Morrow EM.   +12 more
europepmc   +1 more source

The T‐Cell Response Mechanism in Human Papillomavirus‐Associated Cervical Cancer and New Strategies for Immunotherapy

iNew Medicine, EarlyView.
ABSTRACT Human papillomavirus (HPV) is a double‐stranded DNA virus that infects human skin and mucosal tissues exclusively. The German scientist Harald zur Hausen was awarded the 2008 Nobel Prize in Physiology or Medicine for his discovery of the link between HPV infection and cervical cancer.
Fang Zhu, Farah Nazir, Ying Zhou, Yuhua Shang, Hongliang He, Tengchuan Jin   +5 more
wiley   +1 more source