Results 101 to 110 of about 15,277 (204)
携带Egr-1启动子和Endostatin基因的腺病毒穿梭质粒构建及鉴定
Zhongguo shiyan zhenduanxue, 2008 目的构建含辐射敏感启动子Egr-1和人内皮抑素（endostatin）基因的腺病毒穿梭质粒pshuttle-Egr1-Endostatin。方法利用RT-PCR方法从人胎肝中扩增出人endostatin cDNA序列,从T-Egr1质粒中扩增出Egr-1基因序列,并将它们连接到pMD19T质粒进行测序,利用基因重组技术构建含有辐射诱导启动子Egr-1的腺病毒穿梭质粒pshuttle-Egr1-Endostatin。结果经测序证实,获得的人endostatin基因和Egr ...
李艳博 +6 more
doaj
Mediators of Inflammation, 2003 We investigated the serum concentration of endostatin in 84 patients with multiple myeloma (MM) and in 13 healthy controls. The level of measured anti-angiogenic agent was correlated with the phase and stage of the disease, and most importantly with ...
Halina Urbanska-Rys, Tadeusz Robak
doaj +1 more source
Effect of endostatin overexpression on angiotensin II-induced cardiac hypertrophy in rats
Chinese Medical Journal, 2019 . Background:. Endostatin, a biologically active fragment of collagen XVIII, has been observed in patients with ischemic heart disease. The aim of the present study was to investigate whether endostatin overexpression could attenuate cardiac hypertrophy ...
You-Jin Dai +3 more
doaj +1 more source
The response of VEGF-stimulated endothelial cells to angiostatic molecules is substrate-dependent
BMC Cell Biology, 2005 Background The microenvironment surrounding cells can exert multiple effects on their biological responses. In particular the extracellular matrix surrounding cells can profoundly influence their behavior.
Polverini Peter J +5 more
doaj +1 more source
A mathematical model of systemic inhibition of angiogenesis in metastatic development [PDF]
, 2013 We present a mathematical model describing the time development of a population of tumors subject to mutual angiogenic inhibitory signaling. Based on biophysical derivations, it describes organism-scale population dynamics under the influence of three ...
Benzekry, Sebastien +2 more
core +4 more sources
Critical Care, 2018 Background Acute kidney injury (AKI) is associated with high morbidity and mortality in surgical patients. Nonrecovery from AKI may increase mortality and early risk stratification seems key to improving clinical outcomes.
Hui-Miao Jia +8 more
doaj +1 more source
Endostatin in the pancreas [PDF]
British Journal of Cancer, 2005 In this issue of the British Journal of Cancer, Brammer and co-workers investigate the status of endostatin expression in human pancreas cancer and normal pancreatic tissue. Endostatin was originally identified from the conditioned media of glioendothelioma cells as an inhibitor of angiogenesis (O'Reilly et al, 1997).
openaire +2 more sources
Frontiers of antifibrotic therapy in systemic sclerosis [PDF]
, 2017 Although fibrosis is becoming increasingly recognized as a major cause of morbidity and mortality in modern societies, targeted anti-fibrotic therapies are still not approved for most fibrotic disorders. However, intense research over the last decade has
Abraham, DJ +5 more
core
Endorepellin remodels the endothelial transcriptome toward a pro-autophagic and pro-mitophagic gene signature. [PDF]
, 2018 Regulation of autophagy by proteolytically cleaved fragments of heparan sulfate proteoglycans is a novel and current research focus in tumor biology. Endorepellin is the C-terminal angiostatic fragment of the heparan sulfate proteoglycan perlecan and ...
Andreuzzi, Eva +5 more
core +1 more source
Angiogenese - therapeutische Interventionsmöglichkeiten bei rheumatischen Erkrankungen [PDF]
, 2018 Zusammenfassung: Im Gegensatz zur Vaskulogenese bedeutet Angiogenese die Formation neuer Blutgefäße aus bereits bestehenden Gefäßen. Dieser vielschrittige Prozess tritt beim Erwachsenen physiologisch nur während des Reproduktionszyklus und der ...
Distler, J.H.W. +4 more
core