Results 21 to 30 of about 703 (170)

Endostar-loaded PEG-PLGA nanoparticles: in vitro and in vivo evaluation [PDF]

, 2010
Endostar, a novel recombinant human endostatin, which was approved by the Chinese State Food and Drug Administration in 2005, has a broad spectrum of activity against solid tumors.
Hu, Sanyuan, Zhang, Yangde
core   +4 more sources

Recent Developments in Gene Therapy for Neovascular Age-Related Macular Degeneration: A Review [PDF]

, 2023
Age-related macular degeneration (AMD) is a complex and multifactorial disease and a leading cause of irreversible blindness in the elderly population. The anti-vascular endothelial growth factor (anti-VEGF) therapy has revolutionized the management and ...
Finocchio L., Gabai A., Salati C., Spadea L., Toneatto G., Zeppieri M.   +5 more
core   +1 more source

Modulation of extracellular matrix genes reflects the magnitude of physiological adaptation to aerobic exercise training in humans [PDF]

, 2005
BACKGROUND: Regular exercise reduces cardiovascular and metabolic disease partly through improved aerobic fitness. The determinants of exercise-induced gains in aerobic fitness in humans are not known.
Fischer, Helene, Greenhaff, Paul L, Gustafsson, Thomas, Jansson, Eva, Rachman, Jonathan, Ridden, John, Sundberg, Carl Johan, Timmons, James A   +7 more
core   +3 more sources

Localization and characterization of C-type lectin-like family of proteins in Leptospira interrogans [PDF]

, 2007
Genome analysis of Leptospira interrogans serovar Copenhageni reveals the presence of proteins that share a unique conserved domain of unknown function (DUF1554).
Toot, Amanda Lee
core   +3 more sources

New opportunities for bioscaffold‐enabled spinal cord injury repair

BMEMat, EarlyView.
Schematic illustration of bioscaffolds for spinal cord injury repair. We summarize the effects of bioscaffold properties on SCI repair, highlight different types of bioscaffolds, various fabrication strategies, and in vivo transformations for the clinical development of SCI‐repairing bioscaffolds.
Xiaoqing Qi, Yicheng Fu, Zhaoliang Su, Li Li, Subrata Chakrabarti, Peng Li, Yilun Wu, Fang Liu, Teng Gao, Zhifeng Dong, Lei Liu, Pei Cao   +11 more
wiley   +1 more source

Oligomerization-Dependent Regulation of Motility and Morphogenesis by the Collagen Xviii Nc1/Endostatin Domain [PDF]

, 2001
Collagen XVIII (c18) is a triple helical endothelial/epithelial basement membrane protein whose noncollagenous (NC)1 region trimerizes a COOH-terminal endostatin (ES) domain conserved in vertebrates, Caenorhabditis elegans and Drosophila.
Ackley, Binari, Bussolino, Chirgadze, Dhanabal, Dhanabal, Ding, Dixelius, Felbor, Folkman, Gherardi, Giancotti, Grant, Grant, Hall, Hutter, Hynes, Jeffers, Jeffers, John, Kalman, Lo, Muragaki, Muragaki, Musso, O'Reilly, Oh, Park, Potempa, Prockop, Rehn, Rehn, Reichsman, Ridley, Saarela, Sasaki, Sasaki, Schaeffer, Schuppan, Sertie, Standker, Streuli, Tamagnone, Vogel, Wen, Yamaguchi, Yayon   +46 more
core   +4 more sources

Biomarkers of Extracellular Matrix Remodelling Are Linked to Severity and Outcome of Advanced Chronic Liver Disease

Alimentary Pharmacology &Therapeutics, EarlyView.
Extracellular matrix (ECM) remodelling biomarkers reflect portal hypertension and disease severity in advanced chronic liver disease (ACLD). However, their predictive value for disease progression is largely restricted to compensated ACLD (cACLD). ABSTRACT Background Extracellular matrix (ECM) remodelling in advanced chronic liver disease (ACLD) is ...
Benedikt Simbrunner, Ida Falk Villesen, Georg Semmler, Lorenz Balcar, Georg Kramer, Joana Almeida Calvão, Benedikt Silvester Hofer, Mathias Jachs, Lukas Hartl, Jurij Maurer, Bernhard Scheiner, Kerstin Zinober, Rodrig Marculescu, Michael Trauner, Morten Karsdal, Thomas Reiberger, Mattias Mandorfer, Diana Julie Leeming   +17 more
wiley   +1 more source

Endostatin's Antiangiogenic Signaling Network

Molecular Cell, 2004
It is here demonstrated that the set of gene expressions underlying the angiogenic balance in tissues can be molecularly reset en masse by a single protein. Using genome-wide expression profiling, coupled with RT-PCR and phosphorylation analysis, we show that the endogenous angiogenesis inhibitor endostatin downregulates many signaling pathways in ...
Abdollahi, Amir, Hahnfeldt, Philip, Maercker, Christian, Gröne, Hermann-Josef, Debus, Juergen, Ansorge, Wilhelm, Folkman, Judah, Hlatky, Lynn, Huber, Peter E   +8 more
openaire   +2 more sources

Behind the scenes: how the EMILIN/Multimerin family shapes the cancer landscape

The FEBS Journal, EarlyView.
The EMILIN/Multimerin family members regulate key hallmarks of cancer—including apoptosis, angiogenesis, metastasis, and tumor microenvironment remodeling. As indicated, their function in immune evasion, drug resistance, and metabolic reprogramming remains largely unexplored.
Evelina Poletto, Naike Casagrande, Emanuele Di Siena, Greta Carobolante, Lucrezia Camicia, Giorgia Schinello, Samanta Muzzin, Enrica Timis, Paola Spessotto, Maurizio Mongiat   +9 more
wiley   +1 more source

The Nc1/Endostatin Domain of Caenorhabditis elegans Type Xviii Collagen Affects Cell Migration and Axon Guidance [PDF]

, 2001
Type XVIII collagen is a homotrimeric basement membrane molecule of unknown function, whose COOH-terminal NC1 domain contains endostatin (ES), a potent antiangiogenic agent.
Barstead, Baum, Bettinger, Boehm, Brenner, Burdine, Chan, Colavita, Colavita, Costa, Culotti, Desai, Dhanabal, Dinbergs, Emmons, Fire, Fire, Garriga, Gettner, Giancotti, Graham, Guo, Hagg, Hamelin, Hemler, Hutter, Ishii, Jones, Kang, Kim, Kivirikko, Kramer, Kuo, Mello, Muragaki, Muragaki, Musso, O'Reilly, Oh, Oh, Ramchandran, Rehn, Rehn, Rehn, Rogalski, Saarela, Saarela, Sasaki, Sasaki, Sibley, Soker, Stringa, Sulston, Sze, Tavernarakis, Vogel, Wadsworth, White, Williams, Williams-Masson, Yamaguchi, Zipkin   +61 more
core   +3 more sources