Results 51 to 60 of about 3,702 (214)

Linking Antibody Fc Domain to Endostatin Significantly Improves Endostatin Half-life and Efficacy [PDF]

Clinical Cancer Research, 2008
Abstract Purpose: The half-life of the antiangiogenic molecule endostatin that has been used in clinical trial is short (∼2 h). In addition, ∼50% of the clinical grade endostatin molecules lack four amino acids at their NH2 termini. Lack of these amino acids gives rise to a molecule that is devoid of zinc, resulting in no antitumor ...
Tong-Young, Lee, Robert M, Tjin Tham Sjin, Shahla, Movahedi, Bissan, Ahmed, Elke A, Pravda, Kin-Ming, Lo, Stephen D, Gillies, Judah, Folkman, Kashi, Javaherian   +8 more
openaire   +2 more sources

Endostar-loaded PEG-PLGA nanoparticles: in vitro and in vivo evaluation [PDF]

, 2010
Sanyuan Hu1, Yangde Zhang21Xiangya School of Medicine and 2National Hepatobiliary and Enteric Surgery Research Center, Ministry of Health, Central South University, Changsha, Hunan Province, People’s Republic of ChinaAbstract: Endostar, a novel
null Hu, null Yangde Zhang
core   +3 more sources

Pushing Frontiers for Proteoglycans

Proteoglycan Research, Volume 4, Issue 2, April 2026.
ABSTRACT Almost half of proteins have one or more post‐translational glycosylation modifications involving the addition of glycan structures. Proteoglycans are a class of glycosylated proteins with one or more glycosaminoglycan (GAG) chains covalently attached to the core protein.
Marissa L. Maciej‐Hulme
wiley   +1 more source

Circulating angiogenesis‐related biomarkers in sickle cell retinopathy and maculopathy

British Journal of Haematology, Volume 208, Issue 4, Page 1398-1406, April 2026.
Summary Sickle cell disease (SCD), encompassing genotypes such as HbSS and HbSC, leads to retinal complications such as sickle cell retinopathy (SCR) and maculopathy (SCM) through poorly understood mechanisms. This study explored associations of a panel of circulating angiogenesis‐related factors with SCR and SCM.
Rajani P. Brandsen, Ingeborg Klaassen, Renée de Caluwe, Erfan Nur, Bart J. Biemond, Roselie M. H. Diederen, Reinier O. Schlingemann   +6 more
wiley   +1 more source

Optimierung eines orthotopen Pankreaskarzinommodells und seine Anwendung für anti-angiogene Therapieversuche [PDF]

, 2009
Gegenstand dieser Arbeit war die Optimierung bereits bestehender orthotoper Transplantationstechniken von Pankreaskarzinomzelllinien in Tiermodellen. Die optimierten präklinischen Mausmodelle wurden in einer Versuchserie eingesetzt, in die der Effekt ...
Riechmann, Maren
core  

Dietary carbohydrate quality and health : focus on low-grade systemic inflammation and cardiometabolic risk factors [PDF]

, 2020
Dietary carbohydrate quality, characterized by content of whole grain (WG), dietary fiber, and sugars, is important for human health. Whole grain consumption and cereal fiber can reduce the risk of chronic disorders such as cardiovascular disease (CVD ...
Omar, Nor Adila Mhd
core   +1 more source

NOTCH3 CADASIL Variant Receptor Aggregation Requires NOTCH3 Wild‐Type Receptors: Identification of Highly Selective Inhibitors That Block the Process

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
CADASIL is the major cause of early‐onset stroke and cognitive dysfunction, including dementia. It is caused by mutations in the NOTCH3 receptor that result in the formation of protein aggregates in the small vessel walls of the brain. We demonstrated that NOTCH3 CADASIL variant receptor aggregation is strictly dependent on interactions with NOTCH3 ...
Haijiang Wang, Xinxin Liu, Gido Gravesteijn, Alessia Atella, Jin Liu, Julie W. Rutten, Peter ten Dijke, Manuel A. F. V. Gonçalves, Saskia A. J. Lesnik Oberstein, David A. Baker   +9 more
wiley   +1 more source

The Extracellular Matrix and Blood Vessel Formation: Not Just a Scaffold [PDF]

, 2007
The extracellular matrix plays a number of important roles, among them providing structural support and information to cellular structures such as blood vessels imbedded within it.
Alexopoulou AN, Aloisi M, Aumailley M, Babic AM, Baciu PC, Barkalow FJ, Basson CT, Bellon G, Bix G, Bix G, Bonanno E, Bornstein P, Brigstock DR, Chandrasekaran L, Chen E, Chen Y, Chen Y, Choi S, Christiano AM, Cohen IR, Colorado PC, de Agostini A, Delmolino LM, Dixelius J, Dixit VM, Doi M, Drake CJ, Drake CJ, Echtermeyer F, Elenius V, Ellis PD, Fataccioli V, Fears CY, Fleischmajer R, Folkman J, Fouser L, Francis G, George EL, George EL, Gilbert SF, Gotte M, Hadjiargyrou M, Humphries JD, Huxley-Jones J, Ingber D, Inoki I, Iruela-Arispe ML, Iruela-Arispe ML, Ishiguro K, Jain RK, John M. Rhodes, Johnson KJ, Joliot V, Kanda S, Kimizuka F, Kireeva ML, Kivirikko S, Knox S, Kopp HG, Kubota S, L?Heureux N, Lawler J, Leask A, Li D, Li Q, Lin CG, Lin CG, Liu Y, Lohler J, Lyon M, Mao JR, Marneros AG, Menasche M, Michael Simons, Midwood KS, Mitsi M, Myers JC, Nackman GB, O?Brien TP, Olsson AK, Partridge SM, Pasqualini R, Perbal B, Perbal B, Poschl E, Ramchandran R, Ricard-Blum S, Risau W, Robinet A, Rosenbloom J, Roy R, Saarela J, Sakamoto K, Sasaki T, Schwarzbauer JE, Shimo T, Simons M., Sudhakar A, Takagi J, Taverna D, Timpl R, Tkachenko E, Tkachenko E, Todorovicc V, Varki A, Varner JA, Vernon RB, Whelan MC, Wijelath ES, Wolinski H, Woods A, Yang JT, Yi M, Zamir E, Zhou L   +114 more
core   +2 more sources

Biomarkers of Extracellular Matrix Remodelling Are Linked to Severity and Outcome of Advanced Chronic Liver Disease

Alimentary Pharmacology &Therapeutics, Volume 63, Issue 5, Page 648-661, March 2026.
Extracellular matrix (ECM) remodelling biomarkers reflect portal hypertension and disease severity in advanced chronic liver disease (ACLD). However, their predictive value for disease progression is largely restricted to compensated ACLD (cACLD). ABSTRACT Background Extracellular matrix (ECM) remodelling in advanced chronic liver disease (ACLD) is ...
Benedikt Simbrunner, Ida Falk Villesen, Georg Semmler, Lorenz Balcar, Georg Kramer, Joana Almeida Calvão, Benedikt Silvester Hofer, Mathias Jachs, Lukas Hartl, Jurij Maurer, Bernhard Scheiner, Kerstin Zinober, Rodrig Marculescu, Michael Trauner, Morten Karsdal, Thomas Reiberger, Mattias Mandorfer, Diana Julie Leeming   +17 more
wiley   +1 more source

Clinical effects of cisplatin plus recombinant human endostatin (rh-endostatin) intratumoral injection on malignant central airway obstruction: a retrospective analysis of 319 cases [PDF]

, 2021
Yunzhi Zhou, Yongping Gao, Nan Zhang, Xiaoli Li, Hui Wang, Shufang Wang, Jiankun Liu, Hong Gao, Hongwu Wang   +8 more
openalex   +1 more source