Results 71 to 80 of about 1,684,780 (315)

Linking endothelial dysfunction with endothelial cell activation [PDF]

Journal of Clinical Investigation, 2013
The thin layer of cells that lines the interior of blood vessels, known as the endothelium, plays a complex role in vascular biology. The endothelium mediates blood vessel tone, hemostasis, neutrophil recruitment, hormone trafficking, and fluid filtration.
openaire   +2 more sources

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Effect of 8 weeks of Endurance Training and Hydroalcoholic Extract of Olive Leaf on Coronary Vascular Bed Endothelial Disorder and Lipid Profile in Diabetic Male Rats

Journal of Mazandaran University of Medical Sciences, 2021
Background and purpose: Due to the high rate of diabetes in the community and the importance of herbal supplements and exercise in its treatment, the present study aimed at evaluating the effects of hydroalcoholic extract of olive leaf on coronary artery
Samira Yarimir, Maryam Moghimian, Afshin Nazari, Alireza Mirzaei, Hamed Seidi, Mehrnoush Sedighi   +5 more
doaj  

Endothelial activation and blood-brain barrier disruption in neurotoxicity after adoptive immunotherapy with CD19 CAR-T cells

Cancer Discovery, 2017
Lymphodepletion chemotherapy followed by infusion of CD19-targeted chimeric antigen receptor (CAR)-modified T (CAR-T) cells can be complicated by neurologic adverse events (AEs) in patients with refractory B cell malignancies.
Juliane Gust, K. Hay, L. Hanafi, Daniel H. Li, D. Myerson, L. Gonzalez-Cuyar, Cecilia C. S. Yeung, W. Liles, M. Wurfel, José A. López, Jun-Mei Chen, D. Chung, Susanna Harju-Baker, Tahsin Özpolat, Kathleen R. Fink, S. Riddell, D. Maloney, C. Turtle   +17 more
semanticscholar   +1 more source

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Endothelial Responses in Sepsis.

American Journal of Respiratory and Critical Care Medicine, 2020
Endothelial cells (ECs) are vascular nonconventional immune cells that play a major role in the systemic response following bacterial infection to limit its dissemination. Triggered by exposure to pathogens, microbial toxins, or endogenous danger signals,
J. Joffre, J. Hellman, C. Ince, H. Ait-Oufella   +3 more
semanticscholar   +1 more source

Epithelial-endothelial transition and endothelial-mesenchymal transition

The International Journal of Developmental Biology, 2022
The movement of continuous sheets of epithelial cells occurs during embryonic development, tissue repair, and cancer. Common to cellular and molecular principles of collective cell migration, invading cancers seem to reactivate embryonic pathways and patterns of cell movement.
openaire   +3 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

The Cell Type–Specific Functions of miR-21 in Cardiovascular Diseases

Frontiers in Genetics, 2020
Cardiovascular diseases are one of the prime reasons for disability and death worldwide. Diseases and conditions, such as hypoxia, pressure overload, infection, and hyperglycemia, might initiate cardiac remodeling and dysfunction by inducing hypertrophy ...
Beibei Dai, Beibei Dai, Feng Wang, Feng Wang, Xiang Nie, Xiang Nie, Hengzhi Du, Hengzhi Du, Yanru Zhao, Yanru Zhao, Zhongwei Yin, Zhongwei Yin, Huaping Li, Huaping Li, Jiahui Fan, Jiahui Fan, Zheng Wen, Zheng Wen, Dao Wen Wang, Dao Wen Wang, Chen Chen, Chen Chen   +21 more
doaj   +1 more source