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Markers of Endothelial Activation in Preeclampsia

Clinical Laboratory, 2015
The study aimed at finding a laboratory approach to detect endothelial damage in normal pregnancy as well as in pregnancy complicated by preeclampsia using selected markers of endothelial activation.A total of 403 healthy pregnant women without a history of deep vein thrombosis and/or hypertension were prospectively studied.
Martin, Prochazka   +8 more
openaire   +2 more sources

Endothelial RIG-I activation impairs endothelial function

Biochemical and Biophysical Research Communications, 2012
Endothelial dysfunction is a crucial part of the chronic inflammatory atherosclerotic process and is mediated by innate and acquired immune mechanisms. Recent studies suggest that pattern recognition receptors (PRR) specialized in immunorecognition of nucleic acids may play an important role in endothelial biology in a proatherogenic manner.
Tobias, Asdonk   +7 more
openaire   +2 more sources

ENDOTHELIAL ACTIVATION AND ENDOTHELIAL LEUKOCYTE INTERACTION IN HYPERTENSION [PDF]

open access: possibleJournal of vascular research, 2015
Endothelium plays a complex role in vascular biology: regulates blood vessel tone, haemostasis, neutrophil recruitment, hormone trafficking, and fluid filtration.Endothelial adherence and migration of leukocytes into tissue is mediated by different sets of adhesion molecules expressed on activated endothelial cells and their complementary ligands on ...
Mihalj, Martina   +2 more
openaire   +2 more sources

Endothelial-monocyte-activating polypeptide II

The International Journal of Biochemistry & Cell Biology, 1996
Endothelial-monocyte-activating polypeptide II (EMAP II) was initially identified as a product of murine methylcholanthrene A-induced fibrosarcoma cells. The deduced mRNA sequence indicates that EMAP II is synthesised as a 34 kDa precursor molecule (proEMAP) and enzymatically cleaved to produce a biologically active 22 kDa mature polypeptide, which has
M P, Tas, J C, Murray
openaire   +2 more sources

Oxidative stress and endothelial activation

Critical Care Medicine, 2002
The vascular endothelial surface is a major target of oxidative stress, but we are only now beginning to understand the molecular sources and physiologic consequences of such oxidative activity. Along with exogenous oxidants, provided by professional phagocytes or circulating enzymes, vascular cells generate oxidants in response to cytokine and growth ...
openaire   +2 more sources

Endothelial Activation. Sliding Door to Atherosclerosis

Current Pharmaceutical Design, 2005
The vascular endothelium has been long viewed as a simply physical separation between blood and tissue [1]. Over the last two decades a consistent bulk of data demonstrated that endothelium is a widely distributed organ, with a variable degree of heterogeneity among and within tissues [2, 3] and deeply involved in vascular physiology and ...
DESIDERI, GIOVAMBATTISTA, FERRI, CLAUDIO
openaire   +4 more sources

Endothelial cell activation in cutaneous vasculitis

Clinical and Experimental Dermatology, 1996
Markers of endothelial cell activation were measured in 28 patients presenting with various forms of limited or focal type cutaneous vasculitis. Plasma levels of tissue plasminogen activator antigen (t-PA:Ag), plasminogen activator inhibitor type 1 antigen (PAI-1:Ag) and PAI-1 activity, fibrin plate, von Willebrand factor antigen (vWF:Ag), tissue ...
K M, Jurd   +3 more
openaire   +2 more sources

OESTROGEN AND ENDOTHELIAL CELL ANGIOGENIC ACTIVITY

Clinical and Experimental Pharmacology and Physiology, 1996
SUMMARY1. Increasing evidence suggests that oestrogens protect women from cardiovascular disease during their reproductive years. Although most studies by others have examined the effect of oestrogen on vascular smooth muscle cells, we have evaluated the effect of oestrogen on the angiogenic behaviour of endothelial cells.2.
H W, Schnaper   +3 more
openaire   +2 more sources

Heparanase activity in cultured endothelial cells

Journal of Cellular Physiology, 1991
AbstractThis study was undertaken to identify a heparan sulfate (HS) degradation endoglycosidase (heparanase) in cultured endothelial cells (EC) and to characterize the requirements for its release and subsequent degradation of HS side chains in the subendothelial extracellular matrix (ECM). Intact EC, EC lysates, or EC conditioned media from different
K, Godder   +5 more
openaire   +2 more sources

Platelet Activation and Endothelial Cell Dysfunction

Critical Care Clinics, 2020
In sepsis, coagulation is activated and there is an increased risk of developing a consumptive coagulopathy with attendant increase in mortality. The processes that regulate hemostasis evolved as a component of the inflammatory response to infection.
Tom, van der Poll, Robert I, Parker
openaire   +2 more sources

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