Results 221 to 230 of about 5,443,396 (299)

The paracrine effects of tumor cells on endothelial cells and macrophages in brain metastases with different primary sites. [PDF]

Front Immunol
Kaya TA, Stein KP, Neyazi B, Rashidi A, Kahlert UD, Mawrin C, Sandalcioglu IE, Dumitru CA.   +7 more
europepmc   +1 more source

Mr BMT Achieves Systemic Macrophage Replacement With Preservation of Tissue Homeostasis

Advanced Science, EarlyView.
Microglia replacement by bone marrow transplantation (Mr BMT) enables systemic replacement of tissue‐resident macrophages. Despite persistent macrophage and tissue remodeling across multiple organs, core biological functions and innate immune responses remain preserved, supporting long‐term maintenance of organismal homeostasis and the therapeutic ...
Yufei Xu, Miaozhan Zou, Yunshang Bai, Yang He, Zhihao Jin, Baozhi Yang, Jinjin Du, Pei Ouyang, Yuanyuan Cai, Yuheng Zhang, Bingying Du, Chengcheng Ge, Jian‐an Gong, Xiaoyu Li, Yuanyi Zheng, Jing Ding, Bo Peng, Yanxia Rao   +17 more
wiley   +1 more source

Identification of pathological CD133+ endothelial cells in venous malformations. [PDF]

Front Cardiovasc Med
Shawber CJ, Clapp A, Shapiro-Franklin N, Yang S, Harvill MG, Iaconetti E, Schonning MJ, Zeiler AI, Perez M, Koh S, Alkelai A, Wu JK.   +11 more
europepmc   +1 more source

BAP31 Drives Cartilage Calcification through Disruption of Autophagosome–Lysosome Fusion in Osteoarthritis

Advanced Science, EarlyView.
Mechanical stress activates BAP31 in chondrocytes. BAP31 competes with ATG14 for binding to STX17, disrupting the STX17–ATG14 complex required for autophagosome–lysosome fusion. The resultant autophagic flux blockade drives the generation of autophagy‐derived exosomes, which mediate pathological cartilage calcification in OA. Chondrocyte‐targeted BAP31
Zhi‐hua Xu, Ruo‐xin Wang, Feng He, Qian Liu, Fu‐yin Li, Min Hui, Yu‐qian Shi, Yu Jiang, Qing‐hua Li, Jun‐wen Jing, Shi‐bin Yu, Li‐tian Ma, Qian‐nan Niu, Mian Zhang   +13 more
wiley   +1 more source

Role of NR2F2-mediated reprogramming of endothelial cells in glioblastoma progression. [PDF]

iScience
He J, Wang X, Zhang S, Guo D, Sun J.
europepmc   +1 more source

Single‐Cell Dissection of Therapy‐Induced Remodeling Uncovers a Fibroblast‐Driven Immunosuppressive Niche and Targetable Vulnerabilities in Lethal Prostate Cancer

Advanced Science, EarlyView.
Single‐cell longitudinal profiling reveals that androgen‐deprivation therapy induces a DPT+ fibroblast‐complement axis that suppresses macrophage inflammation and drives CD8+ T cell exhaustion in prostate cancer. Concurrently, resistant epithelial subpopulations persist and engage TSPAN1‐ and NRXN1‐mediated programs promoting CRPC and neuroendocrine ...
Yang Chen, Dandan Dong, Jinling Liao, Naikai Liao, Mengqi Liu, Qin Zhang, Siting Chen, Qi Liu, Ying Lu, Tianyu Li, Chunlin Zou, Qiong Song, Qiuyan Wang, Jian Liang, Qiji Xie, Chengyang Li, Mengyun Wang, Jiwen Cheng, Zengnan Mo, Gong‐Hong Wei   +19 more
wiley   +1 more source

Comment on "METTL3-Mediated m6A Modification of FYN: Regulating Tumor-Associated Endothelial Cells in Colorectal Cancer Progression". [PDF]

J Gastroenterol Hepatol
Kumar P, Kumar M, Shahid L, Un Nisa N.
europepmc   +1 more source

MASH Background Confers Enhanced Disease Susceptibility and Acetaminophen Toxicity in iPSC‐Derived Liver Organoids

Advanced Science, EarlyView.
This work establishes a novel method for generating multicellular liver organoids from control and MASH donor iPSCs. The model recapitulates several disease‐specific characteristics, with MASH donor‐derived organoids showing higher susceptibility. Lipidomic profiling of MASH organoids closely resembles MASH liver biopsies.
Ekta Minocha, Ashwani Kumar Gupta, Nate Schmidt, Richard M. Green, John G. Purdy, Jason A. Wertheim   +5 more
wiley   +1 more source

Aerobic Exercise Activates S1PR1 Signaling in Tumor Endothelial Cells to Promote Vascular Function in Pancreatic Cancer. [PDF]

Cancer Res
Ballarò R, Lam T, Pareek S, Lee J, Patel H, Tirumala P, Liu G, Hayek K, Savage H, De Maleki R, Guerrouahen BS, Ngo-Huang A, Parker NH, Katz MHG, Petzel MQ, McAllister F, Wright RD, Roy RA, Abraham RG, Pezeshki K, Tan L, Lorenzi PL, Schadler KL.   +22 more
europepmc   +1 more source

Regenerative effects of RKI-1447 on human corneal endothelial cells: a comparative study. [PDF]

BMC Ophthalmol
Akkaya HS, Kilic-Toprak E, Cort A, Parca O, Toprak I.   +4 more
europepmc   +1 more source