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Endothelial Cells and Inflammation

Clinics in Laboratory Medicine, 1983
Recent studies have brought remarkable progress in the understanding of cellular, subcellular, and molecular mechanisms of endothelial injury and responses to injury, both of which appear to be integral parts of the acute inflammatory response. The possible roles of endothelial surface enzymes in the inflammatory response are explored.
U S, Ryan, J W, Ryan
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Exercise and the endothelial cell

International Journal of Cardiology, 2005
Regular exercise is known to be effective in the prevention and treatment of cardiovascular disease. Among the cardioprotectant mechanisms influenced by exercise, the endothelium is becoming recognised as a major target. Preservation of endothelial cell structure is vital for frictionless blood flow, prevention of macrophage and lipid infiltration and,
Marsh, Susan A., Coombes, Jeff S.
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Endothelial Cell Senescence

2006
The wear and tear processes that are thought to contribute to human ageing may play an important role in the development of vascular diseases. One such process is cellular senescence. In endothelial cells the senescent phenotype can be induced by a number of factors, including telomere damage, oxidative stress and sustained mitogenic stimulation ...
J D, Erusalimsky, D J, Kurz
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Immunophysiology of endothelial cells

Human Physiology, 2006
Endothelial cells of the vascular inner lining, in addition to their barrier functions, play certain regulatory roles. They regulate the blood flow, selective permeability of the vascular walls, blood fluidity, hemostasis, and angiogenesis. Regulation of these physiological functions is mediated by the production of vasoactive molecules and cytokines ...
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Preparation of Endothelial Cells

Current Protocols in Cell Biology, 1998
AbstractEndothelial cells, which line blood vessels, can be prepared from a variety of tissues. They are frequently prepared from the umbilical vein, which is relatively easy to obtain. The procedure is clearly described and provides a large population of highly purified endothelial cells.
H K, Kleinman, M C, Cid
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Endothelial Progenitor Cells

New England Journal of Medicine, 2003
Vascular endothelial cells form a lining — one cell thick — for all the blood vessels in the body, providing a critical interface between the vessel itself and blood-borne elements.
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Platelets and Endothelial Cells

Seminars in Thrombosis and Hemostasis, 2007
The pathogenesis of atherosclerosis, the leading cause of morbidity and mortality in industrial countries, is multifactorial. Atherogenesis, the development of atherosclerotic lesions, is initiated by a mechanical or functional injury of the endothelium.
Dorothea I, Siegel-Axel, Meinrad, Gawaz
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Murine Endothelial Cell Lines as Models of Tumor Endothelial Cells

Clinical Cancer Research, 2004
AbstractIdentification of appropriate models for in vivo and in vitro preclinical testing of inhibitors of tumor angiogenesis and progression is vital to the successful development of anticancer therapeutics. Although the focus is on human molecular targets, most preclinical in vivo efficacy testing occurs in mice.
Jennifer, Walter-Yohrling   +6 more
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Valve Endothelial Cells - Not Just Any Old Endothelial Cells

Current Vascular Pharmacology, 2016
Heart valves are sophisticated cellularised structures that perform a complex series of dynamic functions during each cardiac cycle. The endothelial cells (ECs) that cover both surfaces of the valve, play an important role in ensuring that the valve functions are in an optimal manner.
Napachanok, Mongkoldhumrongkul   +2 more
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Endothelial Cell Damage in Sarcoidosis and Neurosarcoidosis: Autoantibodies to Endothelial Cells

European Neurology, 2008
Damage to the vascular system, of which endothelial cells are the main constituent, may occur in sarcoidosis. Evidence of blood-brain barrier (BBB) disruption is shown in sarcoidosis with central nervous system (CNS) involvement by means of magnetic resonance imaging or computed tomography.
N, Tsukada, N, Yanagisawa, I, Mochizuki
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