Results 51 to 60 of about 1,021,874 (316)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Regulation of tumor angiogenesis by the crosstalk between innate immunity and endothelial cells

Frontiers in Oncology, 2023
Endothelial cells and immune cells are major regulators of cancer progression and prognosis. Endothelial cell proliferation and angiogenesis are required for providing nutrients and oxygen to the nascent tumor and infiltration of immune cells to the ...
Svenja Ebeling, Svenja Ebeling, Anita Kowalczyk, Anita Kowalczyk, Diego Perez-Vazquez, Diego Perez-Vazquez, Irene Mattiola, Irene Mattiola   +7 more
doaj   +1 more source

Intracellular S1P generation is essential for S1P-induced motility of human lung endothelial cells : role of sphingosine kinase 1 and S1P lyase [PDF]

, 2011
Earlier we have shown that extracellular sphingosine-1-phosphate (S1P) induces migration of human pulmonary artery endothelial cells (HPAECs) through the activation of S1P(1) receptor, PKCε, and PLD2-PKCζ-Rac1 signaling cascade.
Sabbadini Roger A., Satish Kalari, Nigel J. Pyne (356726), Garcia, Joe G N, Pyne Nigel J., Nigel J Pyne, Susan Pyne (356727), Natarajan Viswanathan, Pyne, S, Zhao, Y, Roger A. Sabbadini (7924547), Berdyshev, Evgeny V, Garcia, JGN, Roger A Sabbadini, Peter Usatyuk (356723), Garcia Joe G. N., Satish Kalari (307462), Nigel J. Pyne, Berdyshev Evgeny V., Natarajan, V, Usatyuk, Peter, Yutong Zhao, Kalari Satish, Garcia, Joe G.N., Usatyuk, P, Kalari, S, Sabbadini, RA, Viswanathan Natarajan, Roger A. Sabbadini, Joe G. N. Garcia (7923365), Evgeny V Berdyshev, Zhao Yutong, Joe G N Garcia, Sabbadini, Roger A, Pyne, Nigel J, Pyne, NJ, Pyne Susan, Yutong Zhao (356724), Evgeny V. Berdyshev (7924544), Irina Gorshkova (356721), Gorshkova, Irina, Usatyuk Peter, Kalari, Satish, Pyne, Susan, Irina Gorshkova, Gorshkova, I, Evgeny V. Berdyshev, Joe G. N. Garcia, Gorshkova Irina, Peter Usatyuk, Natarajan, Viswanathan, Berdyshev, EV, Susan Pyne, Zhao, Yutong, Viswanathan Natarajan (307479)   +54 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Tumor Endothelial Cells [PDF]

Cold Spring Harbor Perspectives in Medicine, 2011
The vascular endothelium is a dynamic cellular “organ” that controls passage of nutrients into tissues, maintains the flow of blood, and regulates the trafficking of leukocytes. In tumors, factors such as hypoxia and chronic growth factor stimulation result in endothelial dysfunction.
openaire   +2 more sources

Kaposin-B enhances the PROX1 mRNA stability during lymphatic reprogramming of vascular endothelial cells by Kaposi's sarcoma herpes virus. [PDF]

, 2010
Kaposi's sarcoma (KS) is the most common cancer among HIV-positive patients. Histogenetic origin of KS has long been elusive due to a mixed expression of both blood and lymphatic endothelial markers in KS tumor cells.
Kafka, Darren, Koh, Chester J., Aguilar Berenice, Yoo, Jaehyuk, Hong Young-Kwon, Hong, Young-Kwon, Lee, Sunju, Choi, Inho, Yoo Jaehyuk, Haas, Jürgen G., Kang Jinjoo, Lee Ha Neul, Swapnika Ramu, Kang, Jinjoo, Young-Kwon Hong, Juneyong Lee, Ramu, Swapnika, Darren Kafka, Lee, Juneyong, Kafka Darren, Lee Sunju, Choi Inho, Juergen Haas, Haas, Juergen, Lee Juneyong, Sunju Lee, Inho Choi, Ha Neul Lee, Haas Juergen, Aguilar, Berenice, Chester J. Koh, Jinjoo Kang, Chester J Koh, Jaehyuk Yoo, Koh Chester J., Berenice Aguilar, Ramu Swapnika, Lee, Ha Neul   +37 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Anti-endothelial cell antibodies in pathogenesis of vasculitis

Frontiers in Immunology
Vasculitis is a group of syndromes characterized by inflammation, presence of autoantibodies and endothelial cells (ECs) damage, which lead to stenosis or occlusion of the vascular lumen. Anti-endothelial cell antibodies (AECAs) are a heterogeneous group
Tian Zhang, Tian Zhang, Tian Zhang, Liqun Li, Shengshi Huang, Shengshi Huang, Shengshi Huang, Maria N. Starodubtseva, Maria N. Starodubtseva, Ju Liu, Ju Liu, Ju Liu   +11 more
doaj   +1 more source

Relevance of monocytic features for neovascularization capacity of circulating endothelial progenitor cells [PDF]

, 2003
Background— Transplantation of ex vivo expanded circulating endothelial progenitor cells (EPCs) from peripheral blood mononuclear cells improves the neovascularization after critical ischemia. However, the origin of the endothelial progenitor lineage and
Dimmeler, S, Heeschen, C, Aicher, A, Urbich, C, Zeiher, AM, Dernbach, E   +5 more
core  

Endothelial cells as targets for antigen-specific cytotoxic T lymphocytes [PDF]

, 2010
BACKGROUND: In this study we have examined human vascular endothelial cells as targets for antigen-specific cytotoxic T lymphocytes (CTL). Vascular endothelial cells (EC) act as the major interface between blood and tissues and are crucial for the ...
Thommen, Daniela Stefanie
core   +1 more source