Results 71 to 80 of about 550,585 (195)

PECAM-1 engagement counteracts ICAM-1-induced signaling in brain vascular endothelial cells [PDF]

, 2007
Interactions between leukocytes and vascular endothelial cells are mediated by a complex set of membrane adhesion molecules which transduce bi-directional signals in both cell types.
Adamson, Barreiro, Barreiro, Butcher, Carman, Carman, Carson, Celli, Christine Rampon, Cicmil, Doulet, Durieu-Trautmann, Engelhardt, Etienne, Etienne, Etienne-Manneville, Federici, Gopalakrishnan, Graesser, Gratzinger, Greenwood, Greenwood, Henshall, Hoffmann, Ilan, Jackson, Jean-Pierre Couty, John Greenwood, Kontaridis, Lacalle, Marie-Pierre Laran-Chich, Masuda, Mathilde Leveque, Millan, Muller, Newman, Newman, Patil, Pierre-Olivier Couraud, Pluskota, Reid, Rivard, Roux, Sander, Sandrine Bourdoulous, Schenkel, Schoenwaelder, Schweitzer, Shaw, Viegas, Walters, Wang, Yang, Yang   +53 more
core   +2 more sources

Time, the final frontier

Molecular Oncology, EarlyView.
This article advocates integrating temporal dynamics into cancer research. Rather than relying on static snapshots, researchers should increasingly consider adopting dynamic methods—such as live imaging, temporal omics, and liquid biopsies—to track how tumors evolve over time.
Gautier Follain, Michal Dibus, Omkar Joshi, Guillaume Jacquemet   +3 more
wiley   +1 more source

Interplay of integrins and selectins in metastasis

Molecular Oncology, EarlyView.
Here we review the role of integrins and their interplay with selectins in metastasis. The efficacy of integrin‐targeted therapies may be reduced in tumors where metastasis relies heavily on selectins. In certain tumors, integrins and selectins exhibit a synergistic interaction during intraperitoneal dissemination.
Diana Maltseva, Ashot Nersisyan, Alexander Tonevitsky   +2 more
wiley   +1 more source

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

MicroRNA regulation of endothelial homeostasis and commitment—implications for vascular regeneration strategies using stem cell therapies [PDF]

, 2013
Human embryonic (hESC) and induced pluripotent (hiPSC) stem cells have broad therapeutic potential in the treatment of a range of diseases, including those of the vascular system.
Andrew H. Baker, Bonauer, Calatayud Maldonado, Caporali, Card, Case, Chambers, Chen, Chen, Cordes, Dews, Elizabeth Scott, Fang, Fang, Fasanaro, Feng, Fichtlscherer, Fong, Foshay, Fu, Geiszt, Gorski, Graeme Milligan, Grundmann, Guo, Harris, Hassel, Houbaviy, Howard, Hua, Humar, Iaconetti, Iorio, Jakob, Ji, Joanne Mountford, Kane, Kane, Kanellopoulou, Kazenwadel, Knight, Komal Loya, Kong, Kuehbacher, Lakshmipathy, Lange, Laurent, Lee, Lee, Lee, Lee, Lee, Li, Lin, Lou, Lou, Luczak, Lund, Magenta, Marson, McDonald, Mineno, Miyoshi, Murai, Murchison, O'Donnell, Ono, Otsubo, Poliseno, Qi, Rhee, Rosa, Rottiers, Sauer, Schmelter, Sessa, Shi, Shilo, Smith, Stadler, Suarez, Suarez, Suh, Sun, Takahashi, Taylor, Taylor, Thomson, Tojo, Treguer, Uno, Ushio-Fukai, Ushio-Fukai, van Grunsven, Wang, Wang, West, White, Wightman, Wigle, Wurdinger, Xu, Yu, Zhang, Zhang   +104 more
core   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

Occlusion of retinal capillaries caused by glial cell proliferation in chronic ocular inflammation [PDF]

, 2015
The inner blood-retinal barrier is a gliovascular unit in which glial cells surround capillary endothelial cells and regulate retinal capillaries by paracrine interactions.
Artico, Marco, Bianchi, Enrica, Feher, Janos, Kovacs, Illés, Plateroti, Andrea Maria, Plateroti, Pasquale, Plateroti, Rocco, Ripandelli, Guido, Taurone, Samanta   +8 more
core   +2 more sources

Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren, Moana Busch, Pedro A. Ruiz, Ermanno Malagola, Valeria Baumeler, Federica Foti, Adelina Gross, Tobias Grütter, Hendrik Edel, Cordelia Schuler, Kristina Handler, Glenn De Lange, Isabelle C. Arnold, Cheryl de Vallière, Klaus Seuwen, Martin Hausmann, Gerhard Rogler   +16 more
wiley   +1 more source

Nitric oxide enhances de novo formation of endothelial gap junctions [PDF]

, 2003
Objective: Gap junctions (formed by connexins, Cx) are important for functional coordination of cells in the vascular wall. However, little is known about their physiological regulation in this tissue.
Gloe, Torsten, Hoffmann, Anke, Pohl, Ulrich, Zahler, Stefan   +3 more
core   +1 more source

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

Molecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte, Osheen Sharma, Laura Leuenberger, Emelie Wallin, Josefin Fernebro, Päivi Östling, Rebecka Bergström, Johan Lindberg, Ulrika Joneborg, Olli Kallioniemi, Brinton Seashore‐Ludlow   +10 more
wiley   +1 more source