Results 201 to 210 of about 627,382 (283)

BGN/MDK Axis in the Melanoma Tumor Microenvironment Strengthens Tumor Malignancy by Modulating Cancer Cells and Cancer‐Associated Fibroblasts Crosstalk

Advanced Science, EarlyView.
This study reveals that m6A regulators cooperatively upregulate BGN in melanoma, promoting malignancy. Within the tumor microenvironment, CAFs show highest BGN expression. The BGN/MDK axis mediates cancer‐stroma crosstalk, driving normal fibroblast (NF) activation and enhancing the pro‐tumor effect of CAFs, highlighting a promising therapeutic target ...
Hao‐ze Shi, Ming‐yang Wu, Jin‐quan Liu, Cuicui Tian, Li Ma, Xue‐mei Zhou, Ze‐Hao Sun, Zhi‐yong Xu, Run‐dong Zhang, Shan‐yuan Ye, Li‐ming Huang, Yan Wang, Jing‐shu Xiong, Wen‐bo Bu, Xian‐feng Cheng, Jian‐fang Sun, Hao Chen   +16 more
wiley   +1 more source

Gut metabolites identified in cerebrospinal fluid of genetic interferonopathy support gut-brain endothelial dysfunction. [PDF]

Clin Transl Immunology
Dale RC, Elbourne M, Hofer MJ, Patel S, Mohammad S, Han VX, Yu J, Fu S, D'Silva A, Farrar MA, Bandodkar S, Yan JJ.   +11 more
europepmc   +1 more source

Ufmylation‐Deficient DDRGK1 Ameliorates Obesity by Inhibiting FASN‐Mediated Adipocyte Lipogenesis

Advanced Science, EarlyView.
DDRGK1 regulates de novo lipogenesis via stabilization of fatty acid synthase (FASN). DDRGK1‐mediated UFMylation of FASN prevents its ubiquitin–proteasomal degradation. Reduced DDRGK1 expression or mutation at the key UFMylation site enhances FASN degradation and suppresses fatty acid synthesis (FAS), resulting in smaller adipocytes and improved ...
Yin Li, Tangjun Zhou, Xiao Yang, Kewei Rong, Xiankun Cao, Lei Shi, Xin Wang, Hongjin Wan, Lei Cui, Kexin Liu, Tong Xing, Hang Zhang, Chen Zhao, Tingxian Guo, Peixiang Ma, Jie Zhao, An Qin   +16 more
wiley   +1 more source

Vascular Complications of Long COVID-From Endothelial Dysfunction to Systemic Thrombosis: A Systematic Review. [PDF]

Int J Mol Sci
Stojanovic M, Djuric M, Nenadic I, Bojic S, Andrijevic A, Popovic A, Pesic S.   +6 more
europepmc   +1 more source

Irgm1 Improves Postinfarction Cardiac Repair by Promoting Neutrophil Clearance and Efferocytosis

Advanced Science, EarlyView.
The Irgm1‐PDIA3 axis enhances post‐infarction cardiac repair by accelerating neutrophil clearance and facilitating efferocytosis. Irgm1 holds potential as a prognostic biomarker in MI, and LOC14 may represent a therapeutic option to improve cardiac repair, especially in cases of Irgm1 deficiency.
Zeng Wang, Lai Wei, Mingyang Wang, Shanjie Wang, Lili Xiu, Jiaxiang Sun, Rongzhe Lu, Yige Liu, Jiaxin Wang, Fengyi Liu, Weike Liu, Bo Yu, Yong Sun, Xueqin Gao, Shaohong Fang   +14 more
wiley   +1 more source

Atherosclerotic Plaque Crystals Induce Endothelial Dysfunction. [PDF]

Int J Mol Sci
Thazhathveettil J, Gomez SA, Olaoseeji D, Wu R, Sirsjö A, Paramel GV.   +5 more
europepmc   +1 more source

Aberrant Splicing Signatures Underpin Oligodendrocyte Damage in ALS and Neuron Loss in FTD

Advanced Science, EarlyView.
Integrating bulk and single‐nucleus RNA‐seq from ALS and FTD patients, we revealed distinct cellular dysfunctions, with severe oligodendrocyte damage in ALS and pronounced neuron loss in FTD. We identified cell‐type‐specific aberrant splicing events as potential biomarkers with robust classification performance, some of which produce de novo peptides ...
Chen Du, Yinming Li, Rong Wu, Yufei Shen, Jiayi Yang, Xuan Xiao, Yu Zhou   +6 more
wiley   +1 more source

Oxidative Stress and Endothelial Dysfunction in Patients with Hypertensive Nephropathy: Role of the Mediterranean Diet. [PDF]

Int J Mol Sci
Salomone L, Menichelli D, Azzara I, Damosso PM, Cammisotto V, Castellani V, Pignatelli P, Pacella E, Mitterhofer AP, Tinti F, Lai S.   +10 more
europepmc   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Prospective cohort study evaluating risk factors for the development of pasture-associated laminitis in the United Kingdom [PDF]

, 2016
Arita, Asplin, Bailey, Bailey, Beltowski, Blakesley, Borer, Bremer, Brooks, Carter, Cywinska, Dallmeier, Efstathiou, El-Mesallamy, Fesus, Finding, Firshman, Frank, Frank, Giles, Giordano, Greiner, Heinrichs, Henneke, Hinckley, Holbrook, Hotta, Huang, Ingelsson, Johnson, Kearns, Kim, Kullmann, Laat, Lam, Lavoie-Lamoureux, Lim, Luszczynski, Lygren, Macieira, Maleki, Mattu, Morgan, Orth, Ouchi, Pischon, Pleasant, Pollock, Popot, Pratt, Ragab, Reimers, Robin, Rosen, Ruan, Ruan, Ryu, Salazar-Ortiz, Salonen, Sandhu, Schultz, Smith, Stephenson, Takiguchi, Torres, Treiber, Treiber, Treiber, Treiber, Troncoso, Trujillo, Wannamethee, Wray, Wyse, Yang   +74 more
core   +2 more sources