Results 221 to 230 of about 399,722 (264)
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Vascular endothelial dysfunction
Progress in Cardiovascular Diseases, 1997Injury or activation of the endothelium changes its regulatory functions and results in abnormal endothelial cell function. Dysfunction of the endothelium has been defined as an imbalance between relaxing and contracting factors, between procoagulant and anticoagulant mediators or between growth-inhibiting and growth-promoting substances.
De Meyer, G.R.Y., Herman, A.G.
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2015
The hypothesis that preeclampsia phenotypes result from endothelial cell dysfunction has been followed by decades of evidence demonstrating vascular dysfunction and augmented vascular reactivity in preeclampsia. Multiple studies have detected biomarkers of endothelial activation prior to overt disease.
Davidge, Sandra T. +2 more
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The hypothesis that preeclampsia phenotypes result from endothelial cell dysfunction has been followed by decades of evidence demonstrating vascular dysfunction and augmented vascular reactivity in preeclampsia. Multiple studies have detected biomarkers of endothelial activation prior to overt disease.
Davidge, Sandra T. +2 more
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Endothelial dysfunction in hypertension
Acta Cardiologica, 2000Endothelial cells release both relaxing and contracting factors that modulate vascular smooth muscle tone and also participate in the pathophysiology of essential hypertension. Endothelium-dependent vasodilation is regulated primarily by nitric oxide but also by an unidentified endothelium-derived hyperpolarizing factor and by prostacyclin. Endothelium-
P, Puddu +3 more
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Statins and Endothelial Dysfunction
Seminars in Vascular Medicine, 2004The endothelium integrates and modulates critical functions of the arterial wall. As well as regulating vasomotion, it controls inflammation, coagulation, and thrombosis. Many of these actions are mediated through the release of nitric oxide. Endothelial dysfunction is associated with atherosclerosis and its risk factors. It is independently correlated
Eric, Larose, Peter, Ganz
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Mitochondrial dysfunction in the pathogenesis of endothelial dysfunction
Molecular and Cellular Biochemistry, 2023Cardiovascular diseases (CVDs) are a matter of concern worldwide, and mitochondrial dysfunction is one of the major contributing factors. Vascular endothelial dysfunction has a major role in the development of atherosclerosis because of the abnormal chemokine secretion, inflammatory mediators, enhancement of LDL oxidation, cytokine elevation, and ...
Suresh Kumar, Prajapat +2 more
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Endothelial Dysfunction and Hypertension
2016In the past, endothelium was thought to be only a mechanical barrier. Today, endothelium is known to be a tissue regulating vascular tone, cell growth and the interaction between the leukocytes, thrombocytes and the vessel wall. It also synthesizes growth factors and thrombo-regulatory molecules and responds to physical and chemical signals.
Konukoglu, Dildar, Uzun, Hafize
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Endothelial Dysfunction in Atherosclerosis
Journal of Vascular Research, 2008Endothelial injury or dysfunction has been proposed to be one of the initiating events of atherosclerosis and is associated with an apparent decrease in the production of the vasodilator autacoid nitric oxide (NO). The nature of the endothelial dysfunction resulting in an attenuation of NO-mediated responses is unknown although possibilities include ...
R, Busse, I, Fleming
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Smoking and Endothelial Dysfunction
Current Vascular Pharmacology, 2019Cigarette smoking is one of the most important health concerns worldwide. Even though the rate of smoking is declining in developed countries, it is still experiencing growth in developing regions. Many studies have examined the relationship between smoking, as an established risk factor, and cardiovascular diseases. We provide an updated review of the
Golbidi, Saeid +2 more
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Endothelial Dysfunction in Sepsis
Current Vascular Pharmacology, 2013The endothelium takes part in the regulation of numerous physiological functions and lies at the interface of circulating blood and the vessel wall. Under physiological conditions, it is responsible for anticoagulant and anti-adhesive properties, and it regulates vasomotor tone and vascular homeostasis.
Julie, Boisramé-Helms +3 more
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Endothelial Dysfunction and Hypertension
Drugs, 1997Vascular endothelial cells play a key role in cardiovascular regulation by producing a number of potent vasoactive agents, including the vasodilator molecule nitric oxide (NO) and the vasoconstrictor peptide endothelin (ET)-1. A dysfunction of the vascular endothelium has been implicated in the pathophysiology of a number of cardiovascular diseases ...
C J, Ferro, D J, Webb
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