Results 101 to 110 of about 571,172 (234)

MUC15 Ectodomain Architecture Regulates Integrin Clustering to Control Cancer Metastasis

Advanced Science, EarlyView.
This study uncovers a size‐dependent adhesion paradigm, demonstrating that the glycocalyx protein MUC15 suppresses pancreatic cancer progression by attenuating integrin activation, focal adhesion assembly, and YAP mechanotransduction. Integrating computational modeling and experimental validation, the work reveals a mechanical mechanism by which MUC15 ...
Simei Zhang, Hongyuan Zhu, Zeen Zhu, Shuai Wu, Yiqun Song, Jin Wang, Xinlong Chen, Weikun Qian, Jianpeng Li, Yangyang Yue, Qinhong Xu, Zhiping Ruan, Qing Li, Yaomin Zhu, Tian Jian Lu, Guy M. Genin, Feng Xu, Zheng Wang, Min Lin   +18 more
wiley   +1 more source

Methods for evaluating endothelial function: a position statement from the European Society of Cardiology Working Group on Peripheral Circulation [PDF]

, 2011
The endothelium holds a pivotal role in cardiovascular health and disease. Assessment of its function was until recently limited to experimental designs due to its location. The advent of novel techniques has facilitated testing on a more detailed basis,
Abraham, P, Balbarini, A, Blann, A, Boulanger, C M, Cockcroft, J, Cosentino, F, Deanfield, J, Gallino, A, Ikonomidis, I, Kremastinos, D, Landmesser, U, Lekakis, J, Protogerou, A, Stefanadis, C, Tousoulis, D, Vassalli, G, Vink, H, Vlachopoulos, C, Werner, N, Wilkinson, I   +19 more
core   +1 more source

Effects of therapeutic plasma exchange on the endothelial glycocalyx in septic shock

Intensive Care Medicine Experimental, 2021
Background Disruption of the endothelial glycocalyx (eGC) is observed in septic patients and its injury is associated with multiple-organ failure and inferior outcomes.
K. Stahl, Uta Hillebrand, Y. Kiyan, B. Seeliger, Julius J Schmidt, H. Schenk, T. Pape, B. Schmidt, T. Welte, M. Hoeper, A. Sauer, M. Wygrecka, C. Bode, H. Wedemeyer, H. Haller, S. David   +15 more
semanticscholar   +1 more source

Mortality risk stratification for Takotsubo syndrome: Evaluating CRP measurement alongside the InterTAK prognostic score

ESC Heart Failure, Volume 12, Issue 2, Page 1427-1436, April 2025.
Abstract Background and objectives Initially described as a benign acute cardiomyopathy, Takotsubo syndrome has been linked to elevated mortality rates. Emerging evidence suggests that unresolved myocardial inflammation may contribute to this adverse prognosis.
Loïc Faucher, Kensuke Matsushita, Shinnosuke Kikuchi, Taraneh Tatarcheh, Benjamin Marchandot, Amandine Granier, Said Amissi, Antonin Trimaille, Laurence Jesel, Patrick Ohlmann, Kiyoshi Hibi, Valérie Schini‐Kerth, Olivier Morel   +12 more
wiley   +1 more source

Three-dimensional low Reynolds number flows near biological filtering and protective layers

, 2017
Mesoscale filtering and protective layers are replete throughout the natural world. Within the body, arrays of extracellular proteins, microvilli, and cilia can act as both protective layers and mechanosensors.
Battista, Nicholas A., Hamlet, Christina, Miller, Laura A., Pasour, Virginia, Santhanakrishnan, Arvind, Strickland, W. Christopher   +5 more
core   +1 more source

Endothelial Glycocalyx as a Regulator of Fibrotic Processes

International Journal of Molecular Sciences, 2021
The endothelial glycocalyx, the gel layer covering the endothelium, is composed of glycosaminoglycans, proteoglycans, and adsorbed plasma proteins. This structure modulates vessels’ mechanotransduction, vascular permeability, and leukocyte adhesion. Thus,
V. Masola, G. Zaza, A. Arduini, M. Onisto, G. Gambaro   +4 more
semanticscholar   +1 more source

Predictive Factors for Failed Sentinel Lymph Node Mapping in Endometrial Cancer: A Retrospective Multicenter Study

Journal of Surgical Oncology, EarlyView.
ABSTRACT Background and Objectives This study aims to evaluate the predictive factors associated with failed sentinel lymph node (SLN) mapping in a large, retrospective cohort of patients with early‐stage endometrial cancer (EC). Methods We retrospectively evaluated a series of EC patients who underwent laparoscopic SLN mapping with intracervical ...
Cristina Taliento, Gennaro Scutiero, Giuseppe Cucinella, Vito Chiantera, Giovanni Pontrelli, Marko Klaric, Dragan Belci, Martin Steinkasserer, Stefano Restaino, Ruby Martinello, Orsola Brasile, Martina Arcieri, Sara Pregnolato, Giulia Pellecchia, Giulia Soraci, Rosa Taratufolo, Carmelia Milano, Marcello Desgro, Francesca Davià, Mariano Catello Di Donna, Dino Becic, Sara Notaro, Giuseppe Vizzielli, Pantaleo Greco   +23 more
wiley   +1 more source

Glycocalyx Damage Estimated Using Colloidal Iron Staining

Cell Transplantation, 2008
Anionic constituents in the peritubular capillary basement membranes and the glomerular endothelial cells have been demonstrated to function as a size- and charge-selective barrier.
Daoxin Zhang, Yoshitaka Isaka, Ryoichi Imamura, Naotsugu Ichimaru, Yi Shi, Enyu Imai, Ye Tian, Aiji Ohtsuka, Shiro Takahara   +8 more
doaj   +1 more source

Multiscale modeling of physical and biological systems [PDF]

, 2011
This paper was presented at the 3rd Micro and Nano Flows Conference (MNF2011), which was held at the Makedonia Palace Hotel, Thessaloniki in Greece.
3rd Micro and Nano Flows Conference (MNF2011), Karniadakis, GE   +1 more
core  

Dynamic interplay between breast cancer cells and normal endothelium mediates the expression of matrix macromolecules, proteasome activity and functional properties of endothelial cells [PDF]

, 2014
Background Breast cancer\u2013endothelium interactions provide regulatory signals facilitating tumor progression. The endothelial cells have so far been mainly viewed in the context of tumor perfusion and relatively little is known regarding the effects ...
Barbouri, D., Gialeli, C., Karamanos, N.K., Kletsas, D., Passi, A., Viola, M.   +5 more
core   +1 more source