Results 61 to 70 of about 1,444,041 (282)

In vitro human embryonic stem cell hematopoiesis mimics MYB-independent yolk sac hematopoiesis [PDF]

, 2014
Although hematopoietic precursor activity can be generated in vitro from human embryonic stem cells, there is no solid evidence for the appearance of multipotent, self-renewing and transplantable hematopoietic stem cells.
De Bleser, Dominique, De Mulder, Katrien, Kerre, Tessa, Lambrecht, Bart, Leclercq, Georges, Menten, Björn, Philippé, Jan, Taghon, Tom, Van Caeneghem, Yasmine, Van Roy, Nadine, Vandekerckhove, Bart, Vanhee, Stijn, Velghe, Imke, Verstichel, Greet   +13 more
core   +3 more sources

Whole-transcriptome analysis of endothelial to hematopoietic stem cell transition reveals a requirement for Gpr56 in HSC generation

Journal of Experimental Medicine, 2015
Using highly sensitive RNAseq to examine the whole transcriptome of enriched aortic hematopoietic stem cells and endothelial cells, the authors find G-protein–coupled receptor, Gpr56, is required to generate the first HSCs during endothelial to ...
Parham Solaimani Kartalaei, Tomoko Yamada-Inagawa, C. Vink, E. de Pater, Reinier van der Linden, Jonathon Marks-Bluth, Anthon van der Sloot, M. van den Hout, T. Yokomizo, M. Lucila van Schaick-Solernó, R. Delwel, J. Pimanda, W. V. van Ijcken, E. Dzierzak   +13 more
semanticscholar   +1 more source

Nanoparticle-encapsulated siRNAs for gene silencing in the haematopoietic stem-cell niche

Nature Biomedical Engineering, 2020
Bone-marrow endothelial cells in the haematopoietic stem-cell niche form a network of blood vessels that regulates blood-cell traffic as well as the maintenance and function of haematopoietic stem and progenitor cells.
Marvin Krohn-Grimberghe, M. J. Mitchell, Maximilian J. Schloss, Omar F. Khan, G. Courties, P. P. Guimaraes, David Rohde, S. Cremer, Piotr S. Kowalski, Yuan Sun, M. Tan, Jamie Webster, Karin Wang, Y. Iwamoto, Stephen P. Schmidt, G. Wojtkiewicz, Ribhu Nayar, V. Frodermann, M. Hulsmans, Amanda Chung, F. Hoyer, F. Swirski, R. Langer, Daniel G. Anderson, M. Nahrendorf   +24 more
semanticscholar   +1 more source

The effect of bisphosphonates on the endothelial differentiation of mesenchymal stem cells [PDF]

Scientific Reports, 2016
AbstractThe contribution of the local stem cell niche to providing an adequate vascular framework during healing cannot be overemphasized. Bisphosphonates (BPs) are known to have a direct effect on the local vasculature, but their effect on progenitor cell differentiation is unknown.
Sharma, Dileep, Hamlet, Stephen Mark, Petcu, Eugen Bogdan, Ivanovski, Saso   +3 more
openaire   +4 more sources

Specialized mouse embryonic stem cells for studying vascular development. [PDF]

, 2014
Vascular progenitor cells are desirable in a variety of therapeutic strategies; however, the lineage commitment of endothelial and smooth muscle cell from a common progenitor is not well-understood.
Burns, Andrew B, Fan, Yuhong, Glaser, Drew E, Hatano, Rachel, McCloskey, Kara E, Medrzycki, Magdalena   +5 more
core   +1 more source

Jagged1-Notch1-deployed tumor perivascular niche promotes breast cancer stem cell phenotype through Zeb1

Nature Communications, 2020
Zinc finger E-box binding homeobox 1 (Zeb1) has been demonstrated to participate in the acquisition of the properties of cancer stem cells (CSCs). However, it is largely unknown how signals from the tumor microenvironment (TME) contribute to aberrant ...
Huimin Jiang, Chen Zhou, Zhen Zhang, Qiong Wang, Huimin Wei, W. Shi, Jianjun Li, Zhaoyang Wang, Yang Ou, Wenhao Wang, Hang Wang, Quansheng Zhang, Wei Sun, Peiqing Sun, Shuang Yang   +14 more
semanticscholar   +1 more source

On the Hunt for Vascular Endothelial Stem Cells

PLoS Biology, 2012
​InIn the inner blastocyst of early embryos are found pluripotent stem cells, which have the potential to turn into every type of cell in the adult animal. Later in development, stem cells still exist, but they produce a more restricted range of progeny cell types. Tissue-specific stem cells arise that contribute primarily to individual tissues such as
openaire   +5 more sources

Carnosol promotes endothelial differentiation under H2O2-induced oxidative stress [PDF]

Archives of Biological Sciences, 2017
Oxidative stress causes deregulation of endothelial cell differentiation. Carnosol is a potent antioxidant and antiinflammatory compound. In the present study, we examined whether the antioxidant effect of carnosol might protect bone marrow stem
Ou Shulin, Lv Jianfeng, Peng Liming, Zhao Jin, Chi Luxiang   +4 more
doaj   +1 more source

Profoundly reduced neovascularization capacity of bone marrow mononuclear cells derived from patients with chronic ischemic heart disease [PDF]

, 2004
Background— Cell therapy with bone marrow–derived stem/progenitor cells is a novel option for improving neovascularization and cardiac function in ischemic heart disease.
Aicher, A, Assmus, B, Dimmeler, S, Heeschen, C, Honold, J, Lehmann, R, Martin, H, Walter, DH, Zeiher, AM   +8 more
core   +1 more source

Umbilical cord-matrix stem cells induce the functional restoration of vascular endothelial cells and enhance skin wound healing in diabetic mice via the polarized macrophages

Stem cell research & therapeutics, 2020
Chronic nonhealing wounds represent one of the most common complications of diabetes and require advanced treatment strategies. Increasing evidence supports the important role of mesenchymal stem cells in diabetic wound healing; however, the underlying ...
Shichang Zhang, Li Chen, Guoying Zhang, Bo Zhang   +3 more
semanticscholar   +1 more source