Results 1 to 10 of about 23,747,035 (396)
Endothelin-1 in Health and Disease. [PDF]
Int J Mol Sci, 2023 Discovered almost 40 years ago, the potent vasoconstrictor peptide endothelin-1 (ET-1) has a wide range of roles both physiologically and pathologically. In recent years, there has been a focus on the contribution of ET-1 to disease.
Banecki KMRM, Dora KA.
europepmc +4 more sources
Circulating Levels of Endothelin-1 and Big Endothelin-1 in Patients with Essential Hypertension [PDF]
Pathophysiology, 2021 The role of endothelin-1 (ET-1) in the pathogenesis of hypertension (HTN) is not clearly established. There is evidence that its circulating levels are elevated in some forms of experimental and human HTN, but this was not a consistent finding.
Krasimir Kostov, Alexander Blazhev
doaj +3 more sources
Endothelin-1 Production by Normal Human Cultured Keratinocytes and its Regulation [PDF]
Mediators of Inflammation, 1994 The possibility that cultured keratinocytes produce endothelins were investigated. The results showed that cultured keratinocytes derived from normal human skin produce endothelin-1. Moreover, keratinocyte endothelin-1 production was completely inhibited
Hajime Inoue +7 more
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Journal of Ophthalmology, 2016 Purpose. The aim of this meta-analysis was to clarify the association between the plasma endothelin-1 level and the risks of normal tension glaucoma (NTG) and primary open-angle glaucoma (POAG). Methods.
Shengjie Li +3 more
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Endothelin-1 is associated with fibrosis in proliferative diabetic retinopathy membranes [PDF]
PLoS ONE, 2018 To characterize the relationship between endothelin-1 and fibrosis in epiretinal membranes in proliferative diabetic retinopathy and explore the role of endothelial-mesenchymal transition in these membranes.Membranes were obtained from eyes undergoing ...
Amani A Fawzi
exaly +2 more sources
Direct Action of Endothelin-1 on Podocytes Promotes Diabetic Glomerulosclerosis
Journal of the American Society of Nephrology: JASN, 2014 The endothelin system has emerged as a novel target for the treatment of diabetic nephropathy. Endothelin-1 promotes mesangial cell proliferation and sclerosis.
Olivia Lenoir +2 more
exaly +2 more sources
Myocardial ischemia-reperfusion enhances transcriptional expression of endothelin-1 and vasoconstrictor ETB receptors via the protein kinase MEK-ERK1/2 signaling pathway in rat [PDF]
PLoS ONE, 2017 BACKGROUND:Coronary artery remodelling and vasospasm is a complication of acute myocardial ischemia and reperfusion. The underlying mechanisms are complex, but the vasoconstrictor peptide endothelin-1 is suggested to have an important role.
Gry Freja Skovsted, Lars Edvinsson
exaly +2 more sources
Cardiovascular Research, 2013 AIMS The two-pore-domain potassium channel TASK-1 is robustly inhibited by the activation of receptors coupled to the Gα(q) subgroup of G-proteins, but the signal transduction pathway is still unclear.
Moritz Lindner +2 more
exaly +2 more sources
Endothelin-1 Role in Human Eye: A Review
Journal of Ophthalmology, 2010 Endothelin is a potent vasoactive peptide occurring in three isotypes, ET-1, ET-2, and ET-3. Through its two main receptors, endothelin A and endothelin B, it is responsible for a variety of physiological functions, primarily blood flow control.
Serena Salvatore, Enzo Maria Vingolo
doaj +2 more sources
Східноукраїнський медичний журнал, 2021 Endothelial dysfunction is considered one of the main mechanisms for the further development of arterial hypertension (AH) and its complications, and endothelin-1 (ЕТ-1) plays one of the key roles in this process.
Yu. O. Smiianova
doaj +1 more source