Results 101 to 110 of about 23,747,035 (396)
Endothelin-1, aging and hypertension [PDF]
Current Opinion in Cardiology, 2008 Endothelin-1 system activation plays an important role in the etiology of atherosclerotic vascular disease. Aging and hypertension are two independent cardiovascular risk factors that have been shown to exhibit increased endothelin-1 system activation. This review focuses on the cardiovascular effects of the endothelin system, its relation to aging and
Christopher A. DeSouza +2 more
openaire +3 more sources
Assessing candidate DLX‐regulated genes in the first pharyngeal arch of chick embryos
Developmental Dynamics, EarlyView.Abstract Background Insights into the development and evolution of asymmetrical jaws will require an understanding of the gene regulatory networks that underpin the differential morphogenesis of the maxillary and mandibular domains of the first pharyngeal arch in a variety of gnathostomes.
Afshan Sohail +2 more
wiley +1 more source
Clinical trials with endothelin receptor antagonists: What went wrong and where can we improve? [PDF]
, 2012 In the early 1990s, within three years of cloning of endothelin receptors, orally active endothelin receptor antagonists (ERAs) were tested in humans and the first clinical trial of ERA therapy in humans was published in 1995.
Barton, Matthias +4 more
core +1 more source
Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues
ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang +7 more
wiley +1 more source
Modulation of endothelin-1-induced contractions by magnesium/calcium in porcine ciliary arteries [PDF]
, 2018 • Background: The present study was performed to investigate the influence of extracellular magnesium on changes in contractile tone induced by endothelin-1, and on relaxations to bradykinin in isolated porcine ciliary arteries.
Dettmann, Eike +3 more
core
Effects of calcium channel blockers on coronary vasoconstriction induced by endothelin-1 in closed chest pigs [PDF]
, 1990 The purpose of this study was to determine the effects of endothelin-1 on the coronary vascular bed of closed chest pigs. Endothelin-1 (3 to 30 pmol/kg body weight) was selectively administered into the left anterior descending coronary artery.
Egashira, Kensuke +3 more
core +1 more source
Journal of Lipid Research, 2005 There is some controversy regarding whether vascular responses to endothelin are altered in hypercholesterolemia. Studies performed to date have been compromised by the use of endothelin antagonists at inappropriate concentrations.
Lauren M. Boak +3 more
doaj
Endothelin-1 in cardiovascular physiology [PDF]
Clinical Hemorheology and Microcirculation, 1996 Endothelin-l (ET -1) is a 21 amino acid peptide endowed with a a powerful vasoconstrictor activity. The molecular structure and biological activities of endothelin were explored in several studies starting soon after its discovery in 1988, but only recently has the availability of specific ET -1 antagonists allowed its physiological activities to be ...
openaire +3 more sources
Cardiac remodelling in the era of the recommended four pillars heart failure medical therapy
ESC Heart Failure, Volume 12, Issue 2, Page 1029-1044, April 2025.Abstract Cardiac remodelling is a key determinant of worse cardiovascular outcome in patients with heart failure (HF) and reduced ejection fraction (HFrEF). It affects both the left ventricle (LV) structure and function as well as the left atrium (LA) and the right ventricle (RV).
Giada Colombo +7 more
wiley +1 more source
Hemodynamic and inotropic effects of endothelin-1 in vivo [PDF]
, 1994 Endothelin-1 (ET-1) is known to have strong vasoactive properties. Contradictory results have been reported with regard to its inotropic effects. This study examined the dose-dependent (500, 1000, 2500, 5000 and 10,000 ng ET-1/kg vs.
Beyer, M. E. +3 more
core