Spironolactone rescues Dot1a-Af9-mediated repression of endothelin-1 and improves kidney injury in streptozotocin-induced diabetic rats. [PDF]
PLoS ONE, 2012 The molecular mechanism linking aldosterone and endothelin-1 in the development of diabetic nephropathy has not been completely elucidated. Here, we provide evidence showing that streptozotocin-induced diabetic rats have significantly increased ...
Qiaoling Zhou +10 more
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Serum endothelin-1 level positively correlates with waist and hip circumferences in stable coronary artery disease patients [PDF]
Reviews in Cardiovascular Medicine, 2021 Central obesity is associated with increased level and activity of endothelin-1. The waist and hip circumferences are simple indicators of central obesity.
Anggoro Budi Hartopo +3 more
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Definitions, 2020 Endothelin-1 receptor (427 aa, ~49 kDa) is encoded by the human EDNRA gene. This protein is a multipass transmembrane protein that is a receptor for endothelin-1 protein and plays a role in G protein-mediated signal transduction.
semanticscholar +1 more source
Endothelins as mediators in the modulation of cardiac performance [PDF]
Praxis Medica, 2014 The role of endothelin in cardiovascular physiology and pathophysiology has been undeniable ever since its discovery. Endothelins in the heart are important for the development, growth and remodeling, as well as for the control of contractility and ...
Smiljić Sonja +4 more
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Comparison of haemoconcentration induced by big endothelin‐1 and endothelin‐1 in mice [PDF]
British Journal of Pharmacology, 1993 The profile of haemoconcentration induced by big endothelin‐1 (big ET‐1), a precursor of endothelin‐1 (ET‐1), was compared with that induced by endothelin‐1 in mice. ET‐1(1.5 nmol kg−1, i.v.) increased haematocrit in mice, which reached a maximum at 5 min and then returned to the control value within 30 min after the administration, this occurred at ...
Rieko Asakura +6 more
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Vestnik Dermatologii i Venerologii, 2021 Background. Atopic dermatitis is a chronic multifactorial dermatosis with a complex pathophysiological basis. One of the poorly studied links in the pathogenesis of the disease is endothelin-1.
Irina V. Kibalina, Namzhil N. Tsybikov
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Frontiers in Immunology, 2023 Major Histocompatibility Complex (MHC) molecules have been proposed to play a role in Sickle Cell Disease (SCD) pathophysiology. Endothelial cells express MHC molecules following exposure to cytokines.
Yaritza Inostroza-Nieves +6 more
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Regulation of the cardiomyocyte transcriptome vs translatome by endothelin-1 and insulin: translational regulation of 5' terminal oligopyrimidine tract (TOP) mRNAs by insulin [PDF]
, 2010 Background: Changes in cellular phenotype result from underlying changes in mRNA transcription and translation. Endothelin-1 stimulates cardiomyocyte hypertrophy with associated changes in mRNA/protein expression and an increase in the rate of protein ...
Clerk, Angela +5 more
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Endothelium-derived endothelin-1 [PDF]
Pflügers Archiv - European Journal of Physiology, 2009 One year after the revelation by Dr. Furchgott in 1980 that the endothelium was obligatory for acetylcholine to relax isolated arteries, it was clearly shown that the endothelium could also promote contraction. In 1988, Dr. Yanagisawa's group identified endothelin-1 (ET-1) as the first endothelium-derived contracting factor.
David J. Webb, Eric Thorin, Eric Thorin
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Differential regulation of Krüppel-like factor family transcription factor expression in neonatal rat cardiac myocytes: effects of endothelin-1, oxidative stress and cytokines [PDF]
, 2008 Krüppel-like transcription factors (Klfs) modulate fundamental cell processes. Cardiac myocytes are terminally-differentiated, but hypertrophy in response to stimuli such as endothelin-1. H2O2 or cytokines promote myocyte apoptosis. Microarray studies of
Ahmad +61 more
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