Temporal regulation of expression of immediate early and second phase transcripts by endothelin-1 in cardiomyocytes [PDF]
, 2008 Background: Endothelin-1 stimulates Gq protein-coupled receptors to promote proliferation in dividing cells or hypertrophy in terminally differentiated cardiomyocytes.
Alsafi, A. +12 more
core +2 more sources
Heparin inhibits endothelin-1 production in cultured rat mesangial cells [PDF]
, 1994 Heparin inhibits endothelin-1 production in cultured rat mesangial cells. The present study was designed to examine whether heparin inhibits basal or stimulated endothelin-1 production by arginine vasopressin (AVP) and platelet-derived growth factor ...
Horio, Takeshi +6 more
core +1 more source
The FASEB Journal, 2011 Over two decades of research have demonstrated that the peptide hormone endothelin-1 (ET-1) plays multiple, complex roles in cardiovascular, neural, pulmonary, reproductive, and renal physiology. Differential and tissue-specific production of ET-1 must be tightly regulated in order to preserve these biologically diverse actions.
L. Stow, M. E. Jacobs, C. Wingo, B. Cain
semanticscholar +5 more sources
Different role of endothelin ETA and ETB receptors and endothelial modulators in diabetes-induced hyperreactivity of the rabbit carotid artery to endothelin-1 [PDF]
, 2004 The influence of diabetes on regulatory mechanisms and specific receptors implicated in the contractile response of isolated rabbit carotid arteries to endothelin-1 was examined. Endothelin-1 induced a concentration-dependent contraction that was greater
Alabadí Ferrer, José Antonio +4 more
core +2 more sources
An emerging role for microRNA in the regulation of endothelin-1
Frontiers in Physiology, 2013 Endothelin-1 (ET-1) is a peptide signaling molecule serving diverse functions in many different tissues such as the vasculature and the kidney. The primary mechanism thought to control ET-1 bioavailability is the rate of transcription from the ET-1 gene (
Mollie E Jacobs +3 more
doaj +1 more source
Contribution of endothelin receptors and cyclooxygenase-derivatives to the altered response of the rabbit renal artery to endothelin-1 in diabetes [PDF]
, 2006 The influence of diabetes on regulatory mechanisms and specific receptors implicated in the response of isolated rabbit renal artery to endothelin-1 was examined. Endothelin-1 induced a concentration-dependent contraction that was less potent in arteries
Alabadí Ferrer, José Antonio +4 more
core +2 more sources
Endothelin-converting enzyme-1 expression in acute and chronic liver injury in fibrogenesis
Animal Cells and Systems, 2019 Endothelin-1 (ET-1) induces contraction, proliferation, and collagen synthesis of activated hepatic stellate cells and is a potent mediator of portal hypertension.
Tae-Jun Cho, Hyo-Jung Kim, Jaejin Cho
doaj +1 more source
Expression of endothelin-1 and endothelin-1 receptor A in canine mammary tumours
Research in Veterinary Science, 2015 Endothelins and their receptors have been implicated in numerous diseases and have recently emerged as relevant players in a variety of malignancies. Tumours overexpress the Endothelin-1 (ET-1) and the Endothelin-A receptors (ETAR) and their interaction enhances tumour growth and metastasis by promoting tumour cell survival, proliferation and ...
RESTUCCI, BRUNELLA +2 more
openaire +4 more sources
Endothelin-1 in stable bronchiectasis [PDF]
European Respiratory Journal, 2000 Endothelin (ET)-1 has been suggested to promote neutrophil adhesion to endothelium, migration to inflamed areas, and release of elastase. ET-1 might therefore play a role in the pathogenesis of bronchiectasis, a chronic inflammatory and infective airway disease which is still poorly understood.
Ho, JCM +7 more
openaire +5 more sources
Mechanisms underlying diabetes enhancement of endothelin-1-induced contraction in rabbit basilar artery [PDF]
, 2004 The influence of alloxan-induced diabetes on the reactivity of rabbit basilar artery to endothelin-1 was examined. Endothelin-1 induced concentration-dependent contraction of basilar arteries that was higher in diabetic than in control rabbits ...
Alabadí Ferrer, José Antonio +5 more
core +2 more sources