Results 31 to 40 of about 24,309,158 (381)
Endothelin-1 is associated with fibrosis in proliferative diabetic retinopathy membranes. [PDF]
PLoS ONE, 2018 To characterize the relationship between endothelin-1 and fibrosis in epiretinal membranes in proliferative diabetic retinopathy and explore the role of endothelial-mesenchymal transition in these membranes.Membranes were obtained from eyes undergoing ...
William Chang +2 more
doaj +1 more source
Endothelin-converting enzyme-1 expression in acute and chronic liver injury in fibrogenesis
Animal Cells and Systems, 2019 Endothelin-1 (ET-1) induces contraction, proliferation, and collagen synthesis of activated hepatic stellate cells and is a potent mediator of portal hypertension.
Tae-Jun Cho, Hyo-Jung Kim, Jaejin Cho
doaj +1 more source
An emerging role for microRNA in the regulation of endothelin-1
Frontiers in Physiology, 2013 Endothelin-1 (ET-1) is a peptide signaling molecule serving diverse functions in many different tissues such as the vasculature and the kidney. The primary mechanism thought to control ET-1 bioavailability is the rate of transcription from the ET-1 gene (
Mollie E Jacobs +3 more
doaj +1 more source
Contribution of Piezo2 to endothelium-dependent pain. [PDF]
, 2015 BackgroundWe evaluated the role of a mechanically-gated ion channel, Piezo2, in mechanical stimulation-induced enhancement of hyperalgesia produced by the pronociceptive vasoactive mediator endothelin-1, an innocuous mechanical stimulus-induced ...
Bogen, Oliver +3 more
core +2 more sources
Journal of Pharmacological Sciences, 2003 We examined the effect of endothelin-1, endothelin-3 and sarafotoxin S6c on the release of noradrenaline from gastric sympathetic nerve terminals using an isolated, vascularly perfused rat stomach.
Kumiko Nakamura +2 more
doaj +1 more source
Portopulmonary hypertension practice patterns after liver transplantation
Liver Transplantation, EarlyView., 2022 Abstract Portopulmonary hypertension (POPH) is a type of pulmonary arterial hypertension occurring exclusively in those with portal hypertensive liver disease. Liver transplantation (LT) can significantly improve outcomes. Current guidelines counsel against immediate adjustments to targeted therapy after LT and suggest routine echocardiography as ...
Arun Jose +3 more
wiley +1 more source
Temporal regulation of expression of immediate early and second phase transcripts by endothelin-1 in cardiomyocytes [PDF]
, 2008 Background: Endothelin-1 stimulates Gq protein-coupled receptors to promote proliferation in dividing cells or hypertrophy in terminally differentiated cardiomyocytes.
Alsafi, A. +12 more
core +2 more sources
Tumor Biology, 2017 Patients with esophageal squamous cell carcinoma have poor survival and high recurrence rate, thus an effective prognostic biomarker is needed. Endothelin-converting enzyme-1 is responsible for biosynthesis of endothelin-1, which promotes growth and ...
Ching-Fang Wu +6 more
doaj +1 more source
Mitochondrial Fission Inhibitors Suppress Endothelin-1-Induced Artery Constriction
Cellular Physiology and Biochemistry, 2017 Background/Aims: Endothelin-1 is implicated in the pathogenesis of hypertension, but the underlying mechanisms remained elusive. Our previous study found that inhibition of mitochondrial fission of smooth muscle cells suppressed phenylephrine- and high K+
Chang Chen +11 more
doaj +1 more source
Mechanisms underlying diabetes enhancement of endothelin-1-induced contraction in rabbit basilar artery [PDF]
, 2004 The influence of alloxan-induced diabetes on the reactivity of rabbit basilar artery to endothelin-1 was examined. Endothelin-1 induced concentration-dependent contraction of basilar arteries that was higher in diabetic than in control rabbits ...
Alabadí Ferrer, José Antonio +5 more
core +2 more sources