Brazilian Journal of Medical and Biological Research, 2005 Increased pulmonary vascular resistance in preterm newborn infants with respiratory distress syndrome is suggested, and endothelin-1 plays an important role in pulmonary vascular reactivity in newborns.
A.C.W. Benjamin +2 more
doaj +1 more source
p90 ribosomal S6 kinases play a significant role in early gene regulation in the cardiomyocyte response to Gq protein-coupled receptor stimuli, endothelin-1 and α1-adrenergic receptor agonists [PDF]
, 2012 Extracellular signal-regulated kinases 1/2 (ERK1/2) and their substrates, p90 ribosomal S6 kinases (RSKs), phosphorylate different transcription factors, contributing differentially to transcriptomic profiles.
Adachi +43 more
core +1 more source
پزشکی بالینی ابن سینا, 2021 Background and Objective: Due to the significant importance of the teeth in mastication, speech, and aesthetics, it is necessary to identify all involved genes in the tooth development. Therefore, this study aimed to evaluate the role of endothelin-1 and
Soussan Irani +2 more
doaj
Endothelin in health and disease
Biomolecules & Biomedicine, 2004 Endothelin is a recently discovered peptide composed of 21 amino acids. There are three endothelin isomers: endothelin -1 (ET-1), endothelin -2 (ET-2) and endothelin - 3 (ET-3).
Emina Nakaš-Ićindić +3 more
doaj +1 more source
CAQ Corner: Basic concepts of transplant immunology
, 2022 Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley +1 more source
Plasmatic Biochemical Variables Associated with Polymorphisms in the Endothelin-1 and Endothelin-1 Receptor a Genes in Hypertensive Patients: Pilot Study [PDF]
, 2016 Endothelin-1 (ET-1) is a potent vasoconstrictive peptide, and its activity is mediated by thetype A receptor (EDNRA). This action may play a significant role in the etiology of hypertension.There are different works that shows an association between ...
Bertolotto, Patricia Isolina +7 more
core +2 more sources
Production of endothelin‐1 and big‐endothelin‐1 by pleural mesothelial cells
FEBS Letters, 1992 Immunoreactive endothelin‐1 (ET‐1) and big‐endothelin‐1 (big‐ET‐1) were detected in conditioned medium of cultured rat pleural mesothelial cells by using sensitive sandwich‐type enzyme immunoassays. The amount of both ET‐1 and big‐ET‐1 increased time‐dependently. In both instances, maximal amount was detectable in conditioned medium obtained after 72 h
Kuwahara, Masayoshi +2 more
openaire +2 more sources
Drug treatment of hypertension: focus on vascular health [PDF]
, 2016 Hypertension, the most common preventable risk factor for cardiovascular disease and death, is a growing health burden. Serious cardiovascular complications result from target organ damage including cerebrovascular disease, heart failure, ischaemic heart
Cameron, Alan C. +2 more
core +1 more source
Bosentan for digital ulcers prevention does not worsen cardiopulmonary exercise test parameters in SSc patients with interstitial lung disease [PDF]
, 2016 Bosentan for digital ulcers prevention does not worsen cardiopulmonary exercise test parameters in SSc patients with interstitial lung ...
Amoroso, Daria +7 more
core +1 more source
Endothelin-1 Production by Normal Human Cultured Keratinocytes and its Regulation
Mediators of Inflammation, 1994 The possibility that cultured keratinocytes produce endothelins were investigated. The results showed that cultured keratinocytes derived from normal human skin produce endothelin-1. Moreover, keratinocyte endothelin-1 production was completely inhibited
Hajime Inoue +7 more
doaj +1 more source