Results 81 to 90 of about 24,309,158 (381)

Activation of native TRPC1/C5/C6 channels by endothelin-1 is mediated by both PIP3 and PIP2 in rabbit coronary artery myocytes [PDF]

, 2009
We investigate activation mechanisms of native TRPC1/C5/C6 channels (termed TRPC1 channels) by stimulation of endothelin-1 (ET-1) receptor subtypes in freshly dispersed rabbit coronary artery myocytes using single channel recording and ...
Ahmmed, Albert, Albert, Albert, Albert, Albert, Albert, Albert, Anthony P. Albert, Boualleque, Clapham, Davenport, Davenport, Drummond, Fukami, Hamill, Hardie, Helliwell, Inoue, Ivey, Kawanabe, Kinlay, Kwon, Large, Lemonnier, Liu, Miwa, Nakanishi, Nilius, Otsuguro, Peppiatt-Wildman, Rohacs, Saleh, Saleh, Saleh, Schiffrin, Sohag N. Saleh, Sugawara, Sumner, Trebak, Tseng, Vanhaesebroeck, Voets, Wang, William A. Large   +44 more
core   +2 more sources

Endothelin-1 Regulates Oligodendrocyte Development [PDF]

The Journal of Neuroscience, 2009
In the postnatal brain, oligodendrocyte progenitor cells (OPCs) arise from the subventricular zone (SVZ) and migrate into the developing white matter, where they differentiate into oligodendrocytes and myelinate axons. The mechanisms regulating OPC migration and differentiation are not fully defined. The present study demonstrates that endothelin-1 (ET-
Ana, Gadea, Adan, Aguirre, Tarik F, Haydar, Vittorio, Gallo   +3 more
openaire   +2 more sources

NARFL Knockout Triggers Ferroptosis‐Driven Vascular Endothelial Dysfunction

Advanced Science, EarlyView.
NARFL is vital for CIA and oxidative stress resistance. NARFL deletion in HPMEC cells, zebrafish, and mice is lethal and rescued by a Ferroptosis inhibitor. NARFL deficiency disrupted its interaction with CIA proteins, decreased aconitase activity, increased IRP1 activity, induced Fe overload, and led to ferroptosis and oxidative stress, resulting in ...
Hui Hu, Jing Luo, Li Yu, Daoxi Qi, Boyu Li, Yating Chen, Chen Wang, Xiaokang Zhang, Wenzheng Guo, Qiyong Lou, Gang Zhai, Yonglin Ruan, Jianfei Huang, Shengchi Shi, Zhan Yin, Fang Zheng   +15 more
wiley   +1 more source

ERK1/2 signaling dominates over RhoA signaling in regulating early changes in RNA expression induced by endothelin-1 in neonatal rat cardiomyocytes. [PDF]

PLoS ONE, 2010
Cardiomyocyte hypertrophy is associated with changes in gene expression. Extracellular signal-regulated kinases 1/2 (ERK1/2) and RhoA [activated by hypertrophic agonists (e.g.
Andrew K Marshall, Oliver P T Barrett, Timothy E Cullingford, Achchuthan Shanmugasundram, Peter H Sugden, Angela Clerk   +5 more
doaj   +1 more source

Endothelin-1 activity in pregnancy

Journal of Obstetrics and Gynaecology, 2002
Plasma endothelin-1 activity was measured by radioimmunoassay in 24 normotensive non-pregnant women and in 24 normotensive pregnant, 24-aproteinuric hypertensive and 24 pre-eclamptic women. Endothelin-1 activity was increased in the pre-eclamptic group (2.7 +/- 06 pg/ml) compared to the normotensive non-pregnant (1.0 +/- 0.8 pg/ml; P < 0.0001 ...
Shaun M, Khedun, Thajasvarie, Naicker, Jagdisea, Moodley   +2 more
openaire   +2 more sources

Circular RNA PTPN4 Contributes to Blood‐Brain Barrier Disruption during Early Epileptogenesis

Advanced Science, EarlyView.
Epileptic condition induces CircPTPN4 upregulation, which promotes ECE‐1 expression through competitive sequestration of miR‐145a‐5p. The elevated ECE‐1 catalyzes the ET‐1 production, leading to p38/MAPK pathway activation and subsequent downregulation of tight junction protein expression. This cascade results in increased BBB permeability and enhanced
Jiurong Yang, Yang Hu, Feiyu Wang, Xintao Peng, Honggang Qi, Yuanyuan Yao, Canyu Zhang, Lijie Zhou, Xuemei Liang, Kang Xu, Cong Zhang, Aifeng Zhang, Chen Chen, Yu Zeng, Chenchen Zhang, Guangming Gan, Xinjian Zhu   +16 more
wiley   +1 more source

Endothelin-1 Drives Epithelial-Mesenchymal Transition In Hypertensive Nephroangiosclerosis [PDF]

, 2016
BACKGROUND: Tubulointerstitial fibrosis, the final outcome of most kidney diseases, involves activation of epithelial mesenchymal transition (EMT). Endothelin‐1 (ET‐1) activates EMT in cancer cells, but it is not known whether it drives EMT in the kidney.
Belloni, Anna S, Buccella, Valentina, CALO', LORENZO, Caroccia, Brasilina, Gioco, Francesca, Guerzoni, Eugenia, GUIDOLIN, DIEGO, Montini, Barbara, Pagnin, Elisa, Petrelli, Lucia, Piazza, Maria, Ravarotto, Verdiana, ROSSI, GIANPAOLO, SECCIA, TERESA MARIA   +13 more
core   +1 more source

The effect and mechanism of endothelin-1-induced intracellular free calcium in human lung adenocarcinoma cells SPC-A1

Chinese Journal of Lung Cancer, 2008
Background and objective Endothelin-1 (ET-1) is a potent mitogen involved in cell growth in human lung adenocarcinoma cells SPC-A1. The increase in intracellular free calcium ([Ca2+]i) plays a great role in this process.
Juan ZHOU, Weimin ZHANG, Qianjun YE, Gang JIA   +3 more
doaj  

Endothelin-1 Role in Human Eye: A Review

Journal of Ophthalmology, 2010
Endothelin is a potent vasoactive peptide occurring in three isotypes, ET-1, ET-2, and ET-3. Through its two main receptors, endothelin A and endothelin B, it is responsible for a variety of physiological functions, primarily blood flow control.
Serena Salvatore, Enzo Maria Vingolo
doaj   +1 more source

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

Advanced Science, EarlyView.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian, Yi‐Chun Ou, Zi‐Xian Zhang, Jie Cai, Si‐Qing Cai, Guo‐Gang Xing   +5 more
wiley   +1 more source