Results 131 to 140 of about 208,585 (381)

Mono and combination therapies in pulmonary arterial hypertension patients with comorbidities: A COMPERA analysis

open access: yesESC Heart Failure, EarlyView.
AIM This analysis provides a comparison of the efficacy of initial mono and combination therapy in patients with PAH and cardiovascular comorbidities or with risk factors of HFpEF (heart failure with preserved ejection fractioin).METHOD Data from the European COMPERA registry were used for a matched pair analysis.
Dirk Skowasch   +20 more
wiley   +1 more source

Endothelin ETA- and ETB-Receptor-Mediated Inhibition of Noradrenaline Release From Isolated Rat Stomach

open access: yesJournal of Pharmacological Sciences, 2003
We examined the effect of endothelin-1, endothelin-3 and sarafotoxin S6c on the release of noradrenaline from gastric sympathetic nerve terminals using an isolated, vascularly perfused rat stomach.
Kumiko Nakamura   +2 more
doaj  

Early impairment of endothelial structure and function in young normal-weight women with polycystic ovary syndrome [PDF]

open access: yes, 2004
The aim of this study was to evaluate the presence of early vascular damage in young normal-weight women with polycystic ovary syndrome (PCOS).Thirty young normal-weight women with PCOS, who had no additional metabolic or cardiovascular diseases, and 30 ...
B. De Simone   +9 more
core   +1 more source

The effects of early exercise on cardiovascular biomarkers in patients with congestive heart failure

open access: yesESC Heart Failure, EarlyView.
Abstract Background Exercise training improves functional outcomes in chronic heart failure (HF), but the effects of early in‐hospital physical activity on cardiovascular biomarkers and prognosis in acute congestive heart failure (AHF) patients remain unclear.
Yanxiang Sun   +6 more
wiley   +1 more source

Cardiovascular magnetic resonance‐estimated pulmonary capillary wedge pressure, congestion markers, and effect of empagliflozin in patients with heart failure with reduced ejection fraction and dysglycaemia (SUGAR‐DM‐HF)

open access: yesEuropean Journal of Heart Failure, EarlyView.
Abstract Aims A cardiovascular magnetic resonance (CMR) approach to non‐invasively estimate left ventricular (LV) filling pressure was recently developed and shown to correlate with invasively measured pulmonary capillary wedge pressure (PCWP). We examined the association between CMR‐estimated PCWP (CMR‐PCWP) and other imaging and biomarker measures of
Joanna Osmanska   +11 more
wiley   +1 more source

Endothelin and endothelin receptors in the renal and cardiovascular systems

open access: yesLife Sciences, 2012
Endothelin-1 (ET-1) is a multifunctional hormone which regulates the physiology of the cardiovascular and renal systems. ET-1 modulates cardiac contractility, systemic and renal vascular resistance, salt and water renal reabsorption, and glomerular function.
Susi Heiden   +4 more
openaire   +3 more sources

Canagliflozin reduces oral loop diuretic intensification in patients with type 2 diabetes: A participant‐level pooled analysis of the CANVAS and CREDENCE trials

open access: yesEuropean Journal of Heart Failure, EarlyView.
Among high‐risk patients with T2D, new oral loop diuretic intensification was frequent and portended adverse prognostic significance. Treatment with canagliflozin significantly reduced the need for loop diuretic intensification. ABSTRACT Aims The sodium–glucose cotransporter 2 inhibitor canagliflozin reduces the risk of heart failure (HF ...
Safia Chatur   +11 more
wiley   +1 more source

Epidemiología y patogenia de la hipertensión arterial esencial, rol de angiotensina II, óxido nítrico y endotelina

open access: yesActa Médica Costarricense, 2005
Actualmente se considera que la hipertensión arterial esencial es un verdadero problema de salud pública. Se estima que 1/6 de la población mundial sufre la enfermedad y en algunas poblaciones susceptibles la prevalencia es tan alta que 1 de 4 adultos ...
Eduardo Fiedler-Velásquez   +1 more
doaj  

Endothelin Receptor A Blockade Enhances Taxane Effects in Prostate Cancer

open access: yesNeoplasia: An International Journal for Oncology Research, 2006
Endothelin (ET) 1 is important in the growth of prostate cancer cells through the activation of the endothelin A (ETA) receptor. ET receptor blockade is a new therapeutic target in treating advanced prostate cancer.
Ardavan Akhavan   +7 more
doaj   +1 more source

Baseline characteristics and enrichment results from the SONAR trial [PDF]

open access: yes, 2018
Aim: The SONAR trial uses an enrichment design based on the individual response to the selective endothelin receptor antagonist atrasentan on efficacy (the degree of the individual response in the urinary albumin‐to‐creatinine ratio [UACR]) and safety/
Andress, Dennis L.   +15 more
core   +3 more sources

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