Results 241 to 250 of about 162,472 (321)

Arrestin‐centred interactions at the membrane and their conformational determinants

British Journal of Pharmacology, Volume 182, Issue 14, Page 3135-3150, July 2025.
Abstract More than 30 years after their discovery, arrestins are recognised multiprotein scaffolds that play essential roles in G protein‐coupled receptor (GPCR) regulation and signalling. Originally named for their capacity to hinder GPCR coupling to G proteins and facilitate receptor desensitisation, arrestins have emerged as key hubs for a myriad of
Owen Underwood, Raphael Silvanus Haider, Julie Sanchez, Meritxell Canals   +3 more
wiley   +1 more source

Crosstalk Between Gastric Cancer and Adjacent Mucosa Reveals EDN1-EDNRA-Mediated Regulation of Cancer Stemness and Immunomodulation Networks. [PDF]

J Cell Mol Med
Zhu X, Zhang Y, Liao H, Hu J, Xiao X.
europepmc   +1 more source

Fetal Circulatory Endothelin-1,2 in the Midtrimester

, 1993
Eyed Schiff, Y. Zalel, Steven A. Friedman, Eliezer Shalev   +3 more
openalex   +1 more source

Pathogenesis of Melasma Explained

International Journal of Dermatology, Volume 64, Issue 7, Page 1201-1212, July 2025.
Pathophysiology of melasma. ABSTRACT This review provides an in‐depth analysis of the pathophysiology of melasma and highlights recent studies that elucidate its underlying mechanisms. Given the prevalence of melasma, a thorough understanding of its pathogenesis is critical for the development of effective treatment strategies.
Lara Ali, Firas Al Niaimi
wiley   +1 more source

Impact of NA-1 on Pericyte-Driven Vasoconstriction and Its Role in No-Reflow During Cerebral Ischemia-Reperfusion. [PDF]

CNS Neurosci Ther
Yang X, Zhao J, Tian H, Nie X, Zheng L, Liu X, Wei ZZ, Ding Y, Liu L.   +8 more
europepmc   +1 more source

Endothelin regulation of neuropeptide release from nerve endings of the posterior pituitary. [PDF]

, 1992
Marie‐Françoise Ritz, Edward L. Stuenkel, Govindan Dayanithi, Rebecca L. Jones, J J Nordmann   +4 more
openalex   +1 more source

Pathophysiology of Wound Development and Chronicity in Renal Disease: A Narrative Review

International Wound Journal, Volume 22, Issue 7, July 2025.
ABSTRACT Renal disease, including chronic kidney disease (CKD) and end‐stage renal disease (ESRD), has a profound impact on wound healing. Multiple studies have demonstrated that renal disease leads to an increased risk of diabetic foot ulcers, the formation of unique wounds like calciphylaxis, slower wound healing and a higher risk of amputation. This
Kirtana Sandepudi, Krish V. Shah, Bradley A. Melnick, Rena A. Li, Kelly Ho, Madeline J. O'Connor, Robert D. Galiano   +6 more
wiley   +1 more source

Clinical significance of HIF-1α, ET-1, and NO as biomarkers in chronic obstructive pulmonary disease patients with pulmonary hypertension. [PDF]

Biomol Biomed
Zhang X, Zhou Y, Zhang H.
europepmc   +1 more source

Polar secretion of endothelin-1 by cultured endothelial cells.

, 1992
Oswald Wagner, G Christ, Johann Wojta, H. Vierhapper, Sabina Parzer, P. Nowotny, Barbara Schneider, W. Waldhäusl, Bernd R. Binder   +8 more
openalex   +1 more source

Modulatory Role of Nitric Oxide on the Vasomotor Actions of NPY in Porcine Cerebral Arteries

Microcirculation, Volume 32, Issue 5, July 2025.
ABSTRACT Neuropeptide Y (NPY) is a sympathetic co‐transmitter that mediates vasoconstriction. However, there is evidence that it may also mediate dilation through a nitric oxide (NO)‐dependent mechanism. Objective We used a swine model to examine how NPY influences cerebral vascular regulation and hypothesized that NPY would elicit both vasoconstrictor
Gabriela Delgado, Cameron J. Morse, Breanna Barlage, M. Harold Laughlin, Craig A. Emter, Erika M. Boerman, Jaume Padilla, Corey R. Tomczak, T. Dylan Olver   +8 more
wiley   +1 more source