Results 231 to 240 of about 63,830 (268)

Endothelin in cardiovascular control: The role of endothelin antagonists

Current Hypertension Reports, 1999
Endothelin (ET) is a potent vasoconstrictor associated with various cardiovascular diseases. ET mediates its effects through ET receptors on vascular smooth muscle cells as well as on the vascular endothelium. Furthermore, a neurotransmitter role for ET has been suggested on the basis of experimental and human in vivo studies. ET antagonists are potent
R R, Wenzel, P, Czyborra, T, Lüscher, T, Philipp   +3 more
openaire   +2 more sources

Localization of Endothelin-1 and Endothelin-3 in the Cochlea

Acta Oto-Laryngologica, 1997
The distribution of endothelin-1 (ET-1) and endothelin-3 (ET-3) was studied by indirect immunostaining of decalcified guinea pig and rat cochleae. No species differences were observed. Perikarya and processes of spiral ganglion cells were highly reactive for both ET-1 and ET-3.
P, Franz, C, Hauser-Kronberger, M, Egerbacher, P, Böck, M, Stach, C, Quint, S, Aharinejad   +6 more
openaire   +2 more sources

Development of a Photolabile Ligand for the Endothelin-A Receptor of Endothelin

Journal of Cardiovascular Pharmacology, 2000
Actions of endothelin (ET) are usually mediated through the so-called endothelin-A or -B (ET(A) or ET(B))-receptors. As part of our ongoing research program, we are studying the characterization of the ET(A)-receptor using specific photolabile ligands.
S, Tessier, C, Langlois, A, Brkovic, M, Coupal, A, De Léan, A, Fournier   +5 more
openaire   +2 more sources

Endothelin and endothelin receptor antagonism in portopulmonary hypertension

European Journal of Clinical Investigation, 2006
AbstractPortopulmonary hypertension (PPHT) is a rare but devastating complication in patients with portal hypertension, characterized by pulmonary arterial obliterative disease with a concomitant rise in pulmonary vascular resistance. A broad body of evidence has accumulated, indicating that endothelin (ET) peptides and their cognate receptors are ...
W, Neuhofer, V, Gülberg, A L, Gerbes
openaire   +2 more sources

Endothelin and endothelin receptors A and B in the human testis

Anatomy and Embryology, 1999
Human testicular capillaries interconnect Leydig cells and seminiferous tubules. Microcirculation and blood flow are therefore essential for the maintenance of spermatogenesis. The expression and the localisation of ET (endothelin) and its receptors in testicular tissue, in seminiferous tubules and in human testicular capillaries were studied.
S, Ergün, S, Harneit, H J, Paust, A K, Mukhopadhyay, A F, Holstein   +4 more
openaire   +2 more sources

Endothelin peptides

Current Opinion in Nephrology and Hypertension, 1996
Application of gene knockout techniques to endothelin research has led to the revelation of unexpected and interesting roles for endothelin isopeptides and their receptors. Homozygous mice with null endothelin-1 and ETA receptors presented with craniofacial and cardiovascular malformations, indicating that these receptors are essential for the ...
openaire   +2 more sources

Endothelin and Endothelin Receptor Antagonism in Heart Failure

Journal of Cardiovascular Pharmacology, 2000
Endothelin (ET)-1 is a potent vasoconstrictor with growth promoting and mitogenic properties associated with various cardiovascular diseases (CVD) and has been found to be an important protagonist in congestive heart failure (CHF). The introduction of ET-1 receptor antagonists into the arena of clinical research has amplified our understanding of the ...
Sütsch G, Kiowski W
openaire   +3 more sources

Endothelin, endothelin receptors, and endothelin antagonists.

Current opinion in nephrology and hypertension, 1995
Endothelin is a peptide with potent biologic effects in vascular and nonvascular cells. Its effects are mediated by two receptors, ETA and ETB, and possibly also by a third receptor, ETC. In vascular smooth muscle cells, endothelin causes profound contraction and also has proliferative effects, mainly through activation of ETA but also through ETB ...
openaire   +1 more source

Endothelins and anti-endothelins.

The Journal of the Association of Physicians of India, 2001
Endothelins, endothelin-1 (ET1), endothelin-2 (ET2) and endothelin-3 (ET3), are the most potent vasoconstrictor peptides released by endothelial cells. ET production is stimulated by vasopressor hormones, platelet-derived factors, coagulation products and cytokines, whereas nitric oxide and prostacyclin reduce ET production.
openaire   +1 more source

Endothelin and Endothelin Antagonists: Pharmacology and Clinical Implications

1995
Endothelins (ET) are a family of peptides with potent biological properties. Endothelial cells produce exclusively ET-1 while other tissues produce ET-2 and ET-3. The production of ET requires an increase in intracellular Ca2+. This increase can be induced by physical chemicals (i.e. hypoxia) or receptor-operated stimuli (i.e. thrombin, angiotensin II,
Lüscher TF, Wenzel RR
openaire   +3 more sources