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Blood Vessels, 2008
The endothelins (ETs) are a family of newly discovered peptides with potent vasoconstrictor properties. They were first discovered in cultured endothelial cells but ET expression has since been found in many other tissues such as brain and kidney. They are peptides with 21 amino acids formed by hydrolytic cleavage of a larger peptide, big ET.
E E, Anggård, R M, Botting, J R, Vane
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The endothelins (ETs) are a family of newly discovered peptides with potent vasoconstrictor properties. They were first discovered in cultured endothelial cells but ET expression has since been found in many other tissues such as brain and kidney. They are peptides with 21 amino acids formed by hydrolytic cleavage of a larger peptide, big ET.
E E, Anggård, R M, Botting, J R, Vane
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Hormone Research, 2008
Endothelin (ET) belongs to a family of 21 amino acid peptides comprising at least three isoforms in man. Originally identified as an endothelium-derived vasoconstrictive substance ET arises from a precursor peptide which is cleaved and released by a specific ET-converting enzyme.
P E, Chabrier, P, Braquet
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Endothelin (ET) belongs to a family of 21 amino acid peptides comprising at least three isoforms in man. Originally identified as an endothelium-derived vasoconstrictive substance ET arises from a precursor peptide which is cleaved and released by a specific ET-converting enzyme.
P E, Chabrier, P, Braquet
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The endothelin system and endothelin receptor antagonists
Current Opinion in Nephrology & Hypertension, 2012There is increasing evidence that endothelin receptor blockade and, in particular, ET(A) receptor blockade not only confers protection against proteinuric renal disease in diabetes but also confers vasculoprotection.Recent clinical trials using ET(A) receptor blockade in treating proteinuria and chronic kidney disease as well as atherosclerosis show ...
Karin A M, Jandeleit-Dahm +1 more
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2006
In humans, the endothelins (ETs) comprise a family of three 21-amino-acid peptides, ET-1, ET-2 and ET-3. ET-1 is synthesised from a biologically inactive precursor, Big ET-1, by an unusual hydrolysis of the Trp21 -Val22 bond by the endothelin converting enzyme (ECE-1).
A P, Davenport, J J, Maguire
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In humans, the endothelins (ETs) comprise a family of three 21-amino-acid peptides, ET-1, ET-2 and ET-3. ET-1 is synthesised from a biologically inactive precursor, Big ET-1, by an unusual hydrolysis of the Trp21 -Val22 bond by the endothelin converting enzyme (ECE-1).
A P, Davenport, J J, Maguire
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Biotinylated endothelin as a probe for the endothelin receptor
Peptides, 1991Biotinylated derivatives of endothelin (ET)-1 were prepared by chemical modification of ET-1 with sulfosuccinimidyl 6-(biotinamido) hexanoate. Two major biotinylated ET analogs were purified by reversed-phase high performance liquid chromatography.
I, Schvartz +4 more
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Regional extraction of endothelins and conversion of big endothelin to endothelin‐1 in the pig
Acta Physiologica Scandinavica, 1991Endothelin‐like immunoreactivity (ET‐LI), mean arterial blood pressure (MABP) and vascular resistance in the spleen, kidney and femoral vascular bed were measured during intravenous infusions (20 pmol. kg‐1. min) of endothelin‐2 (ET‐2), endothelin‐3 (ET‐3), big endothelin‐1 (big ET) and sarafotoxin 6b in the pig.
A, Hemsén, J, Pernow, J M, Lundberg
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Journal of Veterinary Medicine Series A, 1992
SummaryThe endothelins (ET) represent a novel family of at least three isopeptides (ET‐1, ET‐2, ET‐3), each consisting of 21 amino acids and two disulfide bridges. ET has originally been isolated from the supernatant of porcine aortic endothelial cells and has been found to be the most potent and long lasting vasoconstrictor agent yet discovered. ET is
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SummaryThe endothelins (ET) represent a novel family of at least three isopeptides (ET‐1, ET‐2, ET‐3), each consisting of 21 amino acids and two disulfide bridges. ET has originally been isolated from the supernatant of porcine aortic endothelial cells and has been found to be the most potent and long lasting vasoconstrictor agent yet discovered. ET is
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