Results 61 to 70 of about 208,585 (381)
Anti-adrenergic effects of endothelin on human atrial action potentials are potentially anti-arrhythmic [PDF]
, 2006 Endothelin-1 (ET-1) is elevated in patients with atrial fibrillation (AF) and heart failure. We investigated effects of ET-1 on human atrial cellular electrophysiological measurements expected to influence the genesis and maintenance of AF.
Kane, K.A. +3 more
core +1 more source
The Role of Endothelin-1 and Endothelin Receptor Antagonists in Inflammatory Response and Sepsis
Archivum Immunologiae et Therapiae Experimentalis, 2014 Endothelin-1 (ET-1) is a potent endogenous vasoconstrictor, mainly secreted by endothelial cells. It acts through two types of receptors: ETA and ETB.
A. Kowalczyk +4 more
semanticscholar +1 more source
Cell-to-cell communication in bilateral macronodular adrenal hyperplasia causing hypercortisolism
Frontiers in Endocrinology, 2015 It has been well established that, in the human adrenal gland, cortisol secretion is not only controlled by circulating corticotropin but is also influenced by a wide variety of bioactive signals, including conventional neurotransmitters and ...
Herve eLefebvre +11 more
doaj +1 more source
Endothelins and liver cirrhosis
Portal Hypertension & Cirrhosis, 2022 Endothelins are a family of 21‐amino acid oligopeptides, called endothelin‐1 (ET‐1), endothelin‐2 (ET‐2), and endothelin 3 (ET‐3). Endothelins act on hepatocytes, liver endothelial cells, and Kupffer cells in a paracrine or autocrine manner through two G
Necati Örmeci
doaj +1 more source
The role of endothelin-1 in pulmonary arterial hypertension. [PDF]
, 2014 Pulmonary arterial hypertension (PAH) is a rare but debilitating disease, which if left untreated rapidly progresses to right ventricular failure and eventually death. In the quest to understand the pathogenesis of this disease differences in the profile,
Chester, AH, Yacoub, MH
core +1 more source
FEBS Open Bio, EarlyView.The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik +3 more
wiley +1 more source
Vascular fibrosis in aging and hypertension: molecular mechanisms and clinical implications [PDF]
, 2016 Aging is the primary risk factor underlying hypertension and incident cardiovascular disease. With aging, the vasculature undergoes structural and functional changes characterized by endothelial dysfunction, wall thickening, reduced distensibility, and ...
Harvey, Adam +4 more
core +1 more source
Endothelin and restenosis [PDF]
Cardiovascular Research, 1998 Time for primary review 31 days Percutaneous transluminal angioplasty (PTCA) was first introduced into the therapy of patients with coronary artery stenosis in the late seventies [1]. In the two decades since, this method has become standard therapy for patients suffering from all forms of coronary artery disease.
Klaus Münter, Michael Kirchengast
openaire +3 more sources
Advanced Healthcare Materials, EarlyView.Most in vitro cancer models lack cellular diversity, functional complexity, and clinical relevance. This work highlights the generation of an innovative dynamic tetraculture with autologous patient‐derived cells within a vascularized tumor‐on‐chip, as well as the recapitulation of endothelial anergy features induced by the tumor microenvironment ...
Christine Lansche +16 more
wiley +1 more source
Annals of Cardiac Anaesthesia, 2017 Background: The mechanism of development of atrial fibrillation (AF) in patients undergoing coronary artery bypass grafting (CABG) has not been clearly defined, and the involvement of multiple factors such as advanced age, withdrawal of β-blockers ...
Ira Dhawan +5 more
doaj +1 more source