Results 1 to 10 of about 40,821 (327)

The Endothelin Receptor Antagonist Macitentan Inhibits Human Cytomegalovirus Infection [PDF]

Cells, 2021
Human cytomegalovirus (HCMV) infection is an important cause of morbidity and mortality in immunocompromised patients and a major etiological factor for congenital birth defects in newborns.
Natalia Landázuri, Jennifer Gorwood, Ylva Terelius, Fredrik Öberg, Koon Chu Yaiw, Afsar Rahbar, Cecilia Söderberg-Nauclér   +6 more
doaj   +2 more sources

The endothelin receptor antagonist macitentan ameliorates endothelin-mediated vasoconstriction and promotes the survival of retinal ganglion cells in rats [PDF]

Frontiers in Ophthalmology, 2023
Glaucoma is a chronic and progressive eye disease, commonly associated with elevated intraocular pressure (IOP) and characterized by optic nerve degeneration, cupping of the optic disc, and loss of retinal ganglion cells (RGCs).
Bindu Kodati, Bindu Kodati, Wei Zhang, Wei Zhang, Shaoqing He, Jennifer H. Pham, Jennifer H. Pham, Kallen J. Beall, Zoe E. Swanger, Vignesh R. Krishnamoorthy, Payton E. Harris, Trent Hall, Ashley V. Tran, Renuka M. Chaphalkar, Sai H. Chavala, Dorota L. Stankowska, Dorota L. Stankowska, Raghu R. Krishnamoorthy, Raghu R. Krishnamoorthy   +18 more
doaj   +2 more sources

Pipersentan: A De Novo Synthetic Endothelin Receptor Antagonist that Inhibits Monocrotaline- and Hypoxia-Induced Pulmonary Hypertension [PDF]

Frontiers in Pharmacology, 2022
Background: Although major advances have been made in the pathogenesis and management of pulmonary arterial hypertension (PAH), the endothelin system is still considered to play a vital role in the pathology of PAH due to its vasoconstrictive action ...
Zeyu Zhang, Zeyu Zhang, Zeyu Zhang, Chunlei Liu, Chunlei Liu, Yongyi Bai, Xin Li, Xin Li, Xiaojian Gao, Xiaojian Gao, Xiaojian Gao, Chen Li, Chen Li, Ge Guo, Ge Guo, Si Chen, Mingzhuang Sun, Kang Liu, Yang Li, Kunlun He, Kunlun He   +20 more
doaj   +2 more sources

Cardiopulmonary bypass–mediated lung ischemia–reperfusion injury: A protective role of sitaxentan [PDF]

Journal of International Medical Research
Background Cardiopulmonary bypass is widely used in cardiac surgery but often leads to lung ischemia–reperfusion injury, a major cause of morbidity and mortality. Despite advances in critical care, effective prevention remains challenging.
Zhengjia Wang, Renshu Zhan, Liqun Mo, Yingying Zhang, Yirong Chen, Li Liu, Yiping Bai   +6 more
doaj   +2 more sources

ANTIDIURETIC EFFECTS OF THE ENDOTHELIN RECEPTOR ANTAGONIST AVOSENTAN [PDF]

Frontiers in Physiology, 2012
Several clinical studies have investigated the potential benefits of endothelin receptor antagonism in chronic pathologies such as diabetic kidney disease.
Ovidiu Constantin Baltatu, Ovidiu Constantin Baltatu, Radu eIliescu, Christian eZaugg, Jane F. Reckelhoff, Pat eLouie, Christoph eSchumacher, Luciana Aparecida Campos, Luciana Aparecida Campos   +8 more
doaj   +2 more sources

The Anti-Atherosclerotic Effects of Endothelin Receptor Antagonist, Bosentan, in Combination with Atorvastatin—An Experimental Study [PDF]

Int J Mol Sci
Stasinopoulou M, Kostomitsopoulos N, Kadoglou N.   +2 more
europepmc   +3 more sources

Effect of Dual Endothelin Receptor Antagonist on a Retinal Degeneration Animal Model by Regulating Choroidal Microvascular Morphology. [PDF]

J Ophthalmol, 2021
Zhu X, Lin X, Xu Y, Li N, Zhou Q, Sun X, Li Y.   +6 more
europepmc   +3 more sources

Treatment of pulmonary arterial hypertension with the dual endothelin receptor antagonist macitentan: clinical evidence and experience. [PDF]

Ther Adv Respir Dis, 2019
Belge C, Delcroix M.
europepmc   +3 more sources

The Endothelin Receptor Antagonist Macitentan Improves Isosorbide-5-Mononitrate (ISMN) and Isosorbide Dinitrate (ISDN) Induced Endothelial Dysfunction, Oxidative Stress, and Vascular Inflammation. [PDF]

Oxid Med Cell Longev, 2018
Steven S, Oelze M, Hausding M, Roohani S, Kashani F, Kröller-Schön S, Helmstädter J, Jansen T, Baum C, Iglarz M, Schulz E, Münzel T, Daiber A.   +12 more
europepmc   +3 more sources

Aprocitentan: A new development of resistant hypertension

The Journal of Clinical Hypertension, 2023
As the blood pressure threshold for commencing antihypertensive treatment diminishes, the cohort suffering from resistant hypertension (RH) correspondingly expands.
Yao Yao, Bin Fan, Bin Yang, Zixuan Jia, Bao Li   +4 more
doaj   +1 more source