Results 21 to 30 of about 18,729 (264)

Portopulmonary hypertension practice patterns after liver transplantation

Liver Transplantation, EarlyView., 2022
Abstract Portopulmonary hypertension (POPH) is a type of pulmonary arterial hypertension occurring exclusively in those with portal hypertensive liver disease. Liver transplantation (LT) can significantly improve outcomes. Current guidelines counsel against immediate adjustments to targeted therapy after LT and suggest routine echocardiography as ...
Arun Jose, Elizabeth J. Kopras, Shimul A. Shah, Jean M. Elwing   +3 more
wiley   +1 more source

Macitentan, a dual endothelin receptor antagonist, in combination with temozolomide leads to glioblastoma regression and long-term survival in mice

Clinical Cancer Research, 2015
Purpose: The objective of the study was to determine whether astrocytes and brain endothelial cells protect glioma cells from temozolomide through an endothelin-dependent signaling mechanism and to examine the therapeutic efficacy of the dual endothelin ...
Sun-jin Kim, Ho Jeong Lee, Mark S Kim, H. Choi, Junqin He, Qiuyu Wu, K. Aldape, J. Weinberg, W. K. Alfred Yung, C. Conrad, R. Langley, François Lehembre, U. Regenass, I. Fidler   +13 more
semanticscholar   +1 more source

Pharmacological Potential of Endothelin Receptors Agonists and Antagonists

Acta Medica, 2005
Endothelins are potent predominantly vasoconstricting agents that act as local autocrine and paracrine mediators. Endothelin-1 is the most potent and sustained vasoconstrictor and pressor substance yet identified.
Jiří Patočka, Vladimír Měrka, Vratislav Hrdina, Radomír Hrdina   +3 more
doaj   +1 more source

Fluorescence Correlation Spectroscopy in Drug Discovery: Study of Alexa532-Endothelin 1 Binding to the Endothelin ETA Receptor to Describe the Pharmacological Profile of Natural Products

The Scientific World Journal, 2012
Fluorescence correlation spectroscopy and the newly synthesized Alexa532-ET1 were used to study the dynamics of the endothelin ETA receptor-ligand complex alone and under the influence of a semisynthetic selective antagonist and a fungal extract on ...
Catherina Caballero-George, Thomas Sorkalla, Daniel Jakobs, Jessica Bolaños, Huzefa Raja, Carol Shearer, Eldredge Bermingham, Hanns Häberlein   +7 more
doaj   +1 more source

The Discovery of Macitentan – A Standard Medicinal Chemistry Program?

CHIMIA, 2017
A plethora of properties are typically studied during a medicinal chemistry program and many of these parameters may shape the cascade of compound selection.
Martin H. Bolli
doaj   +1 more source

Effect of the endothelin type A–selective endothelin receptor antagonist ambrisentan on digital ulcers in patients with systemic sclerosis: Results of a prospective pilot study

Journal of American Academy of Dermatology, 2014
The dual endothelin receptor antagonist (ETRA) bosentan has been cited as useful in the prevention but not healing of digital ulcers (DUs) in patients with systemic sclerosis (SSc).
L. Chung, Katharine Ball, Aaliya Yaqub, B. Lingala, D. Fiorentino   +4 more
semanticscholar   +1 more source

Endothelin-1, over-expressed in SOD1G93A mice, aggravates injury of NSC34-hSOD1G93A cells through complicated molecular mechanism revealed by quantitative proteomics analysis

Frontiers in Cellular Neuroscience, 2022
Endothelin-1 (ET-1), a secreted signaling peptide, is suggested to be involved in multiple actions in various tissues including the brain, but its role in amyotrophic lateral sclerosis (ALS) remains unknown.
Yingzhen Zhang, Lin Chen, Zhongzhong Li, Dongxiao Li, Yue Wu, Yansu Guo, Yansu Guo, Yansu Guo   +7 more
doaj   +1 more source

Acute Pressor Response to Psychosocial Stress Is Dependent on Endothelium‐Derived Endothelin‐1

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
BackgroundAcute psychosocial stress provokes increases in circulating endothelin‐1 (ET‐1) levels in humans and animal models. However, key questions about the physiological function and cellular source of stress‐induced ET‐1 remain unanswered.
Brandon M. Fox, Bryan K. Becker, Analia S. Loria, Kelly A. Hyndman, Chunhua Jin, Hannah Clark, Robin Johns, Masashi Yanagisawa, David M. Pollock, Jennifer S. Pollock   +9 more
doaj   +1 more source

CAQ Corner: Basic concepts of transplant immunology

, 2022
Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley   +1 more source

Endothelin ETA- and ETB-Receptor-Mediated Inhibition of Noradrenaline Release From Isolated Rat Stomach

Journal of Pharmacological Sciences, 2003
We examined the effect of endothelin-1, endothelin-3 and sarafotoxin S6c on the release of noradrenaline from gastric sympathetic nerve terminals using an isolated, vascularly perfused rat stomach.
Kumiko Nakamura, Shoshiro Okada, Kunihiko Yokotani   +2 more
doaj   +1 more source