Results 91 to 100 of about 304,614 (388)

The dual endothelin converting enzyme/neutral endopeptidase inhibitor SLV-306 (daglutril), inhibits systemic conversion of big endothelin-1 in humans [PDF]

, 2012
Aims - Inhibition of neutral endopeptidases (NEP) results in a beneficial increase in plasma concentrations of natriuretic peptides such as ANP.
Alison Seed, Ando, Anthony P. Davenport, Battistini, Bayes, Bucchwalder-Csajka, Chen, Christopher Hillier, D'Orleans-Juste, Davenport, Davenport, Davenport, Dhaun, Dickstein, Dive, Emoto, Favrat, Fecteau, Ferro, Fiona Johnston, Flather, Garg, Hand, Hanka J. de Voogd, Hans Essers, Haynes, Haynes, Janet J. Maguire, Jardine, John McMurray, Johnstrom, Kentsch, Ling, Love, Maguire, Maguire, Maguire, McDonagh, McDowell, Naruse, Newby, Northridge, Northridge, O'Connell, Palmer, Plumpton, Rhoda E. Kuc, Richards, Richards, Richards, Rousso, Russell, Russell, Russell, Russell, Schirger, Tabrizchi, Thöne-Reinke, Vachiéry, Van der Meer, Xu, Yanagisawa, Yusuf   +62 more
core   +2 more sources

Assessing candidate DLX‐regulated genes in the first pharyngeal arch of chick embryos

Developmental Dynamics, EarlyView.
Abstract Background Insights into the development and evolution of asymmetrical jaws will require an understanding of the gene regulatory networks that underpin the differential morphogenesis of the maxillary and mandibular domains of the first pharyngeal arch in a variety of gnathostomes.
Afshan Sohail, Olivia Nicoll, Andrew J. Bendall   +2 more
wiley   +1 more source

Endothelin receptor A antagonism attenuates renal medullary blood flow impairment in endotoxemic pigs. [PDF]

PLoS ONE, 2011
BACKGROUND: Endothelin-1 is a potent endogenous vasoconstrictor that contributes to renal microcirculatory impairment during endotoxemia and sepsis. Here we investigated if the renal circulatory and metabolic effects of endothelin during endotoxemia are ...
Johan Fenhammar, Andreas Andersson, Jakob Forestier, Eddie Weitzberg, Alf Sollevi, Hans Hjelmqvist, Robert Frithiof   +6 more
doaj   +1 more source

Endothelin Receptor Antagonists and Cardiovascular Disease [PDF]

Drugs in R & D, 1999
Adis Comment All drugs appearing in the Adis Profile Summary table have been selected based on information contained in RD 2 (1): 13-16 1174-5886/99/0007-0013/$02.00 ...
Blair Jarvis, Rosemary Duff, Shelley Elkinson   +2 more
openaire   +2 more sources

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Endothelin receptor antagonists for pulmonary arterial hypertension [PDF]

Cochrane Database of Systematic Reviews, 2009
Pulmonary arterial hypertension is a devastating disease that leads to right heart failure and premature death. Endothelin receptor antagonists have shown efficacy in the treatment of pulmonary arterial hypertension.To evaluate the efficacy of endothelin receptor antagonists (ERAs) in pulmonary arterial hypertension.We searched the Cochrane Central ...
Kunshen Liu, Yanqiu Gao, Chao Liu, Junmin Chen, Bao Deng   +4 more
openaire   +5 more sources

Cardiac remodelling in the era of the recommended four pillars heart failure medical therapy

ESC Heart Failure, Volume 12, Issue 2, Page 1029-1044, April 2025.
Abstract Cardiac remodelling is a key determinant of worse cardiovascular outcome in patients with heart failure (HF) and reduced ejection fraction (HFrEF). It affects both the left ventricle (LV) structure and function as well as the left atrium (LA) and the right ventricle (RV).
Giada Colombo, Tor Biering‐Sorensen, Joao P. Ferreira, Carlo Mario Lombardi, Andrea Bonelli, Andrea Garascia, Marco Metra, Riccardo M. Inciardi   +7 more
wiley   +1 more source

The endothelin A receptor and epidermal growth factor receptor signaling converge on β-catenin to promote ovarian cancer metastasis [PDF]

, 2012
Aims: Endothelin A receptor (ETAR) and epidermal growth factor receptor (EGFR) cross-talk enhances the metastatic potential of epithelial ovarian cancer (EOC) cells activating different pathways, including β-catenin signalling.
Bagnato, Anna, Cianfrocca, Roberta, Di Castro, Valeriana, Rosanò, Laura, Spinella, Francesca, Tocci, Piera   +5 more
core   +1 more source

The effects of sodium–glucose cotransporter 2 inhibitors on the ‘forgotten’ right ventricle

ESC Heart Failure, Volume 12, Issue 2, Page 1045-1058, April 2025.
Abstract With the progress in diagnosis, treatment and imaging techniques, there is a growing recognition that impaired right ventricular (RV) function profoundly affects the prognosis of patients with heart failure (HF), irrespective of their left ventricular ejection fraction (LVEF).
Liangzhen Qu, Xueting Duan, Han Chen
wiley   +1 more source

A review of sitaxsentan sodium in patients with pulmonary arterial hypertension

Vascular Health and Risk Management, 2007
Aaron B WaxmanDepartment of Internal Medicine, Pulmonary Critical Care Unit, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USAAbstract: Pulmonary arterial hypertension (PAH) is a life threatening, progressive condition which ...
Aaron B Waxman
doaj