Results 181 to 190 of about 304,614 (388)

Acute and short-term effects of the nonpeptide endothelin-1 receptor antagonist bosentan in humans [PDF]

, 2018
Summary: In recent years, evidence from various animal experiments has accumulated that emphasizes the role of endothelin-1 in the pathophysiology of several cardiovascular diseases, including congestive heart failure.
Bertel, Osmund, Kiowski, Wolfgang, Sütsch, Gabor   +2 more
core  

The Role of Stromal Tumor Environment in Advancing Skin Cancer Diagnosis and Treatment

International Journal of Dermatology, EarlyView.
ABSTRACT The stromal tumor environment (STE) plays a vital yet often underrecognized role in cancer progression, shaping tumor development. It influences complex interactions among stromal cells, immune cells, extracellular matrix (ECM) components, and signaling molecules.
Frank Jing, Ani Pazhava, Catherine Shachaf, Alexander Meves   +3 more
wiley   +1 more source

Use of a nonselective endothelin receptor antagonist in idiopathic pulmonary hypertension

Терапевтический архив, 2010
Idiopathic (primary) pulmonary hypertension (IPH) is a rare disease of unknown etiology, which is characterized by elevated pulmonary artery pressure, increased total pulmonary vascular resistance, frequently a malignant course with evolving right ...
Ol'ga Aleksandrovna Arkhipova, Tamila Vital'evna Martynyuk, Valentina Kirillovna Lazutkina, Dil'bar Mukumovna Ataullakhanova, Ol'ga Vladimirovna Stukalova, Nikolay Mikhaylovich Danilov, Lyudmila Evgen'evna Samoylenko, Irina Evgen'evna Chazova, O A Arkhipova, T V Martynyuk, V K Lazutkina, D M Ataullakhanova, O V Stukalova, N M Danilov, L E Samoilenko, I E Chazova   +15 more
doaj  

Erectile dysfunction in dermatology and venereology: From aetiopathogenic mechanisms to practical considerations for dermato‐venereologists

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Multiple inflammatory, infectious and autoimmune dermato‐venereological conditions are associated with erectile dysfunction (ED) due to underlying intricate vasculogenic, neurogenic, endocrine and psychogenic mechanisms. It is recommended that practitioners screen dermatology patients for ED and associated comorbidities, provide personalized lifestyle ...
Andrei Tanasov, George‐Sorin Tiplica
wiley   +1 more source

A review of pulmonary arterial hypertension: role of ambrisentan

Vascular Health and Risk Management, 2007
Robyn J BarstColumbia University College of Physicians & Surgeons, New York, NY, USAAbstract: Pulmonary arterial hypertension (PAH) is a rare fatal disease.
Robyn J Barst
doaj  

Dual ET_A-ET_B receptor antagonism improves metabolic syndrome-induced heart failure with preserved ejection fraction. [PDF]

Fundam Clin Pharmacol
Abstract Background Metabolic syndrome (MetS) is a multifaceted disease associated with heart failure (HF), which affects the vascular system. The endothelin (ET) system is a key player in MetS and HF; therefore, targets for ET receptors are of therapeutic interest.
Lockwood F, Lachaux M, Harouki N, Soulié M, Nicol L, Renet S, Dumesnil A, Vercauteren M, Bellien J, Iglarz M, Richard V, Mulder P.   +11 more
europepmc   +2 more sources

Effects of gestational intermittent hypoxia on the respiratory system: A tale of the placenta, fetus, and developing offspring

Journal of Sleep Research, EarlyView.
Effects of gestational intermittent hypoxia on maternal, fetal and offspring respiratory system. In black, effects in humans; in red, in vitro effects; in blue, effects in animal models. Summary Obstructive sleep apnea (OSA) is a common sleep disorder that is associated with a wide variety of health conditions, including cardiovascular, cerebrovascular,
Esther Valverde‐Pérez, Elena Olea, Asunción Rocher, Philip I. Aaronson, Jesús Prieto‐Lloret   +4 more
wiley   +1 more source

Predicting novel pharmacological activities of compounds using PubChem IDs and machine learning (CID-SID ML model) [PDF]

arXiv
Significance and Object: The proposed methodology aims to provide time- and cost-effective approach for the early stage in drug discovery. The machine learning models developed in this study used only the identification numbers provided by PubChem.
arxiv  

BQ123, an ETA Receptor Antagonist, Attenuates Endothelin-1-Induced Vasoconstriction in Rat Pulmonary Circulation

, 1993
S. T. Bonvallet, Masahiko Oka, M. Yano, Martin R. Zamora, Ivan F. McMurtry, Thomas J. Stelzner   +5 more
openalex   +1 more source

Pathophysiologic correlates of exercise intolerance in adults with pulmonary hypertension and congenital heart disease [PDF]

, 2009
Imperial Users ...
Diller , Gerhard-Paul, Diller , Gerhard-Paul   +1 more
core