Advances in the management of diabetic kidney disease: beyond sodium-glucose co-transporter 2 inhibitors [PDF]
Kidney Research and Clinical Practice, 2022 Progress in the treatment of diabetic kidney disease (DKD) has been modest since the early trials on renin-angiotensin-aldosterone system inhibitors (RAASis).
Anthony T. P. Chan, Sydney C. W. Tang
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Pulmonary Circulation, 2020 Many patients with pulmonary arterial hypertension do not achieve treatment goals with monotherapy, and therefore combination therapy is becoming the standard of care.
Hossein-Ardeschir Ghofrani +10 more
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Slow receptor dissociation kinetics differentiate macitentan from other endothelin receptor antagonists in pulmonary arterial smooth muscle cells. [PDF]
PLoS ONE, 2012 Two endothelin receptor antagonists (ERAs), bosentan and ambrisentan, are currently approved for the treatment of pulmonary arterial hypertension (PAH), a devastating disease involving an activated endothelin system and aberrant contraction and ...
John Gatfield +4 more
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EGF Receptor Transactivation by Endothelin-1 Increased CHSY-1 Mediated by NADPH Oxidase and Phosphorylation of ERK1/2 [PDF]
Cell Journal, 2021 Objective: Growth factors [transforming growth factor-β (TGF-β), epidermal growth factor (EGF), endothelin-1 (ET-1)] stimulate proteoglycan synthesis resulting in retention and accumulation of low density lipoprotein (LDL) in vessel intima and leading to
Hossein Babaahmadi-Rezaei +5 more
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Biomarker profiles of acute heart failure patients with a mid-range ejection fraction [PDF]
, 2017 OBJECTIVES: In this study, the authors used biomarker profiles to characterize differences between patients with acute heart failure with a midrange ejection fraction (HFmrEF) and compare them with patients with a reduced (heart failure with a ...
Bloomfield, Daniel M +16 more
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Endothelin receptor B antagonists decrease glioma cell viability independently of their cognate receptor [PDF]
, 2008 Background: Endothelin receptor antagonists inhibit the progression of many cancers, but research into their influence on glioma has been limited. Methods: We treated glioma cell lines, LN-229 and SW1088, and melanoma cell lines, A375 and WM35 ...
A Bagnato +42 more
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The role of endothelin-1 in pulmonary arterial hypertension. [PDF]
, 2014 Pulmonary arterial hypertension (PAH) is a rare but debilitating disease, which if left untreated rapidly progresses to right ventricular failure and eventually death. In the quest to understand the pathogenesis of this disease differences in the profile,
Chester, AH, Yacoub, MH
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مجله دانشکده پزشکی اصفهان, 2018 Background: Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (Nox) is one of the predominant sources of the production of free oxygen radicals in the vascular wall.
Parisa Dayati +3 more
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Different role of endothelin ETA and ETB receptors and endothelial modulators in diabetes-induced hyperreactivity of the rabbit carotid artery to endothelin-1 [PDF]
, 2004 The influence of diabetes on regulatory mechanisms and specific receptors implicated in the contractile response of isolated rabbit carotid arteries to endothelin-1 was examined. Endothelin-1 induced a concentration-dependent contraction that was greater
Alabadí Ferrer, José Antonio +4 more
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Therapeutic efficacy of TBC3711 in monocrotaline-induced pulmonary hypertension
Respiratory Research, 2011 Background Endothelin-1 signalling plays an important role in pathogenesis of pulmonary hypertension. Although different endothelin-A receptor antagonists are developed, a novel therapeutic option to cure the disease is still needed.
Brandes Ralf P +13 more
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