Results 261 to 270 of about 304,614 (388)

Obesity‐related glomerulopathy: How it happens and future perspectives

Diabetic Medicine, Volume 42, Issue 6, June 2025.
Abstract Obesity‐related glomerulopathy (ORG) is an emerging complication of excess adiposity. Its incidence rises alongside the obesity pandemic. Up to 40% of individuals can be affected by ORG, irrespective of the status of glomerular filtration rate and albuminuria.
Jian‐Wen Samuel Lee‐Boey, Jia‐Kai Tan, Zhan‐Foong Lim, Francesco Zaccardi, Kamlesh Khunti, Majid Ezzati, Edward W. Gregg, Lee‐Ling Lim   +7 more
wiley   +1 more source

Single- and multiple-dose tolerability, safety, pharmacokinetics, and pharmacodynamics of the dual endothelin receptor antagonist aprocitentan in healthy adult and elderly subjects. [PDF]

Drug Des Devel Ther, 2019
Sidharta PN, Melchior M, Kankam MK, Dingemanse J.   +3 more
europepmc   +1 more source

Use of adjunctive glycaemic agents with vascular protective properties in individuals with type 1 diabetes: Potential benefits and risks

Diabetes, Obesity and Metabolism, Volume 27, Issue 6, Page 2920-2939, June 2025.
Abstract Glycaemic therapy in type 1 diabetes (T1D) is focused on insulin, with the majority of studies investigating different insulin preparations, delivery devices and dosing accuracy methods. While insulin deficiency is the key mechanism for hyperglycaemia in T1D, individuals with this condition can also develop insulin resistance (IR), making ...
Ahmad M. Rajab, Sam Pearson, Ramzi A. Ajjan   +2 more
wiley   +1 more source

Endothelin-A-Receptor Antagonist and Oral Prostacyclin Analog are Comparably Effective in Ameliorating Pulmonary Hypertension and Right Ventricular Hypertrophy in Rats

, 2000
Michihiko Ueno, Takashi Miyauchi, Satoshi Sakai, Katsutoshi Goto, Iwao Yamaguchi   +4 more
openalex   +1 more source

Endothelin-receptor antagonist treatment of portopulmonary hypertension [PDF]

, 2004
Lukas Hinterhuber, I Graziadei, Charlene M. Kahler, Werner Jaschke, W Vogel   +4 more
openalex   +1 more source

Cardioprotective and Anti‐Hypertensive Effects of Epigallocatechin Gallate: Novel Insights Into Biological Evidence

The Journal of Clinical Hypertension, Volume 27, Issue 6, June 2025.
ABSTRACT Epigallocatechin gallate (EGCG), the major catechin in green tea, is of considerable interest principally due to its proposed antihypertensive and cardioprotective properties. New research shows that EGCG can help relax the circulation of blood vessels, reduce arterial stiffness of arteries, and promote antioxidant activity promotion, which ...
Reza Eshraghi, Ashkan Bahrami, Faraz Tayyar Iravanlou, Mehdi Karimi, Mohammad Saeed Soleimani, Mohammad Hossein Paknahad, Mohammad Yaghoubi, Arman Beheshtirooy, Fatemeh Qasemi Talouki, Javad Shaabanzadeh, Fatemeh Hasani, Alireza Rafi, Mohammad Hossein Pourhanifeh   +12 more
wiley   +1 more source

Functional Role of Endogenous Endothelin-1 in Congestive Heart Failure Treated with Angiotensin II Receptor Antagonist.

, 2001
Kaoru Dohi, Katsuya Onishi, Tetsuya Kitamura, Tsutomu Okinaka, Masaaki Ito, Naoki Isaka, Takeshi Nakano   +6 more
openalex   +2 more sources

Tezosentan, an endothelin receptor antagonist, limits liver injury in endotoxin challenged cirrhotic rats [PDF]

, 2004
Waldemar Urbanowicz
openalex   +1 more source

Dose‐Dependent Acute and Sustained Renal Effects of the Endothelin Receptor Antagonist Avosentan in Healthy Subjects

Clinical pharmacology and therapy, 2009
J. Smolander, B. Vogt, M. Maillard, C. Zweiacker, T. Littke, T. Hengelage, Michel Burnier   +6 more
semanticscholar   +1 more source

Multiomics‐Driven Drug‐Cell Interaction Network for Chemotherapy Sensitivity Prediction in Metabolically Defined Triple‐Negative Breast Cancer Subtypes

Journal of Cellular and Molecular Medicine, Volume 29, Issue 11, June 2025.
ABSTRACT Triple‐negative breast cancer (TNBC) is associated with a poor prognosis due to insufficient molecular subtyping precision and limited actionable targets. Although metabolic reprogramming underlies TNBC chemotherapy resistance, establishing metabolic subtyping systems and investigating drug sensitivity across distinct metabolic subgroups could
Jingyuan Zhang, Xuejun Sun
wiley   +1 more source