Results 141 to 150 of about 36,666 (331)
Effects of vasoactive intestinal contractor (VIC) and endothelin on intracellular calcium level in neuroblastoma NG108‐15 cells [PDF]
, 1989 Tao Fu +6 more
openalex +1 more source
Cardiovascular Plasticity and Adaptation of High‐Altitude Birds and Mammals
Integrative Zoology, EarlyView.This schematic depicts the cardiovascular adaptations of mammals and birds to high‐altitude hypoxia. It highlights key phenotypic changes in oxygen transport and cardiac responses, driven by molecular mechanisms including transcriptional regulation and genetic modifications.
Huishang She, Yanhua Qu
wiley +1 more source
Involvement of endothelins, peptides with potent vasoactive properties, in HIV-1 encephalopathy [PDF]
, 1992 Bogner, Johannes R. +11 more
core +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aerospace medicine required controlled terrestrial models to investigate influences of altered atmosphere conditions, such as hypoxia, on human health and performance. These models could potentially be expanded to encompass disease conditions or treatment targets regulated through hypoxia or hypercapnia.
Titiaan E. Post +4 more
wiley +1 more source
Advancing antihypertensive drug development
British Journal of Pharmacology, EarlyView.Hypertension affects more than a billion individuals worldwide and remains a major cause of cardiovascular morbidity and mortality. Despite advances in therapies, optimal blood pressure control remains elusive for many patients because of treatment resistance, adverse effects, and adherence challenges.
Fay Pu +5 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose TMEM16A Ca2+‐gated Cl− channels mediate depolarisation of contractile vascular cells. The anthelmintic niclosamide was reported to modulate the TMEM16A channel, suggesting possible repurposing for vascular pharmacology. Here, we investigate the mechanism of TMEM16A modulation by niclosamide and explore its effect on the ...
Rachel Kaye +5 more
wiley +1 more source
Endothelium and endothelial dysfunction - health implications and risk for cardiovascular diseases [PDF]
, 2012 The endothelium forms the lining of tunica intima, a single cell layer at the interface between the blood and the extravascular fluid spaces. Not many years ago ther endothelium was considered a simple structural barrier that merely modulated permeation ...
Novotny, J. +2 more
core
Role of Histone Deacetylase and Inhibitors in Cardiovascular Diseases
Cell Proliferation, EarlyView.HDACs play an important role in the occurrence and development of cardiovascular diseases, such as myocardial hypertrophy, hypertension, and atherosclerosis. HDAC inhibitors have broad prospects for the treatment of CVD, and different HDAC subtypes can act through different mechanisms.
Li‐Ying Zhang +4 more
wiley +1 more source