Results 311 to 320 of about 36,666 (331)
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Development of a Photolabile Ligand for the Endothelin-A Receptor of Endothelin
Journal of Cardiovascular Pharmacology, 2000Actions of endothelin (ET) are usually mediated through the so-called endothelin-A or -B (ET(A) or ET(B))-receptors. As part of our ongoing research program, we are studying the characterization of the ET(A)-receptor using specific photolabile ligands.
S Tessier +5 more
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Endothelin and endothelin antagonists in hypertension
Journal of Hypertension, 1998The endothelins (ET) are potent 21-amino-acid vasoconstrictor peptides produced in many different tissues, particularly in the endothelium of blood vessels. ET-1 is the main endothelin secreted by the endothelium, and acts in a paracrine or autocrine fashion on blood vessels by interacting with ETA or ETB receptors on smooth muscle to stimulate ...
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Regional extraction of endothelins and conversion of big endothelin to endothelin‐1 in the pig
Acta Physiologica Scandinavica, 1991Endothelin‐like immunoreactivity (ET‐LI), mean arterial blood pressure (MABP) and vascular resistance in the spleen, kidney and femoral vascular bed were measured during intravenous infusions (20 pmol. kg‐1. min) of endothelin‐2 (ET‐2), endothelin‐3 (ET‐3), big endothelin‐1 (big ET) and sarafotoxin 6b in the pig.
Jan M. Lundberg +2 more
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Current Opinion in CARDIOLOGY, 1995
The endothelins, 21-amino-acid peptides produced by the endothelium of blood vessels and many other tissues such as the kidney, brain, endocrine organs, etc., are potent vasoconstrictors, and are also endowed with mitogenic and cell hypertrophic properties.
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The endothelins, 21-amino-acid peptides produced by the endothelium of blood vessels and many other tissues such as the kidney, brain, endocrine organs, etc., are potent vasoconstrictors, and are also endowed with mitogenic and cell hypertrophic properties.
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Cardiovascular Research, 1998
Time for primary review 30 days It is generally accepted that the vascular endothelium is not a simple barrier between the blood stream and vascular bed. It has many functions in the regulation of vascular function that are mediated by various factors released from the endothelium which act on itself or other vascular cells in autocrine and paracrine ...
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Time for primary review 30 days It is generally accepted that the vascular endothelium is not a simple barrier between the blood stream and vascular bed. It has many functions in the regulation of vascular function that are mediated by various factors released from the endothelium which act on itself or other vascular cells in autocrine and paracrine ...
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Endothelin in cardiovascular control: The role of endothelin antagonists
Current Hypertension Reports, 1999Endothelin (ET) is a potent vasoconstrictor associated with various cardiovascular diseases. ET mediates its effects through ET receptors on vascular smooth muscle cells as well as on the vascular endothelium. Furthermore, a neurotransmitter role for ET has been suggested on the basis of experimental and human in vivo studies. ET antagonists are potent
René R. Wenzel +3 more
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Localization of Endothelin-1 and Endothelin-3 in the Cochlea
Acta Oto-Laryngologica, 1997The distribution of endothelin-1 (ET-1) and endothelin-3 (ET-3) was studied by indirect immunostaining of decalcified guinea pig and rat cochleae. No species differences were observed. Perikarya and processes of spiral ganglion cells were highly reactive for both ET-1 and ET-3.
M Stach +6 more
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2016
Endothelin-1 was isolated from culture supernatant of endothelial cells in 1988. The hormone shows a potent vasoconstructive activity. There are three isopeptides, entothelin-1, -2 and -3 from human genomic analysis, and all endothelins consist of 21 aa residues.
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Endothelin-1 was isolated from culture supernatant of endothelial cells in 1988. The hormone shows a potent vasoconstructive activity. There are three isopeptides, entothelin-1, -2 and -3 from human genomic analysis, and all endothelins consist of 21 aa residues.
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Endothelin and Endothelin Receptor Antagonism in Heart Failure
Journal of Cardiovascular Pharmacology, 2000Endothelin (ET)-1 is a potent vasoconstrictor with growth promoting and mitogenic properties associated with various cardiovascular diseases (CVD) and has been found to be an important protagonist in congestive heart failure (CHF). The introduction of ET-1 receptor antagonists into the arena of clinical research has amplified our understanding of the ...
Wolfgang Kiowski, Gabor Sütsch
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Medicinal Research Reviews, 1997
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Thomas D. Meek, Maria L. Webb
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AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Thomas D. Meek, Maria L. Webb
openaire +4 more sources