Blockade of mitochondrial components release by exosome pathway promotes the pathogenesis of Fuchs endothelial corneal dystrophy [PDF]
Cell Death DiscoveryFuchs endothelial corneal dystrophy (FECD) is the leading indication of corneal transplantation worldwide and the focus of pathogenesis has been on the corneal endothelium. Instead of cellular analysis, we aimed to identify the protein changes of aqueous
Can Zhao +11 more
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Human Bone Derived Collagen for the Development of an Artificial Corneal Endothelial Graft. In Vivo Results in a Rabbit Model. [PDF]
PLoS ONE, 2016 Corneal keratoplasty (penetrating or lamellar) using cadaveric human tissue, is nowadays the main treatment for corneal endotelial dysfunctions. However, there is a worldwide shortage of donor corneas available for transplantation and about 53% of the ...
Natalia Vázquez +9 more
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Research Progress of Polymer Biomaterials as Scaffolds for Corneal Endothelium Tissue Engineering
Nanomaterials, 2023 Nowadays, treating corneal diseases arising from injury to the corneal endothelium necessitates donor tissue, but these corneas are extremely scarce. As a result, researchers are dedicating significant efforts to exploring alternative approaches that do ...
Xiaoying Luo +8 more
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Ciência Rural, 2021 : The objective of this study was to evaluate the acute effects of ropivacaine hydrochloride on the corneal endothelium of horses. Forty-eight eyes were obtained from a commercial slaughterhouse and were randomly divided into three groups.
Marcele de Souza Muccillo +6 more
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Eye, 1990 The endothelium is a monolayer of cells on the posterior corneal surface that transports water from the stroma into the anterior chamber. This movement of water counters a natural tendency for the stroma to swell and is necessary to maintain a transparent cornea.
S J, Tuft, D J, Coster
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PLoS ONE, 2021 Expansion of CTG trinucleotide repeats (TNR) in the transcription factor 4 (TCF4) gene is highly associated with Fuchs Endothelial Corneal Dystrophy (FECD).
Eric D Wieben +7 more
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Feasibility of cell-based therapy combined with descemetorhexis for treating Fuchs endothelial corneal dystrophy in rabbit model. [PDF]
PLoS ONE, 2018 Corneal transparency is maintained by the corneal endothelium through its pump and barrier function. Severe corneal endothelial damage results in dysregulation of water flow and eventually causes corneal haziness and deterioration of visual function.
Naoki Okumura +10 more
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Recovery of Corneal Endothelial Cells from Periphery after Injury. [PDF]
PLoS ONE, 2015 Wound healing of the endothelium occurs through cell enlargement and migration. However, the peripheral corneal endothelium may act as a cell resource for the recovery of corneal endothelium in endothelial injury.To investigate the recovery process of ...
Sang Ouk Choi +7 more
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Generation and Feasibility Assessment of a New Vehicle for Cell-Based Therapy for Treating Corneal Endothelial Dysfunction. [PDF]
PLoS ONE, 2016 The corneal endothelium maintains corneal transparency by its pump and barrier functions; consequently, its decompensation due to any pathological reason causes severe vision loss due to corneal haziness.
Naoki Okumura +8 more
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Evaluation of equine corneal endothelium after exposure to 0.05% brilliant blue - an in vitro study [PDF]
Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2019 The aim of this study was to evaluate the immediate effects of 0.05% brilliant blue on corneal endothelium of horses. Thirty-eight corneas of 19 horses, male or female, of different ages were studied. Corneas were randomly divided into two groups.
M.C.C. Andrade +4 more
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