Results 171 to 180 of about 20,473 (266)

Sex differences in congenital hereditary endothelial dystrophy (CHED) and Slc4a11^-/- mouse model of CHED. [PDF]

Biol Sex Differ
Zhang W, Ramya DS, Araujo E, Venkatakrishnan J, Gupta S, Matsubayashi I, Morselli M, Kaginalkar A, Chaurasia S, Pellegrini M, Tandon R, Ramappa M, Arnold A, Aldave AJ.   +13 more
europepmc   +1 more source

Diabetic Peripheral Neuropathy: Molecular Staging, Risk Factors, Therapeutics, and Emerging Trends

Med Research, Volume 2, Issue 2, Page 309-342, June 2026.
The heterogeneous landscape of DPN can be unified through a tripartite pathogenic model encompassing progressive stages of metabolic dysregulation, chronic inflammation, and overt neuronal damage. Within this framework, six clinical subtypes were identified, namely, hyperglycemia‐driven, dyslipidemia‐driven, inflammation‐driven, dysvascularity‐driven ...
Xiaofeng Dai, Mingze Tang
wiley   +1 more source

Early Transcriptomic and Pathologic Changes of Col8a2 Mutant Fuchs Endothelial Corneal Dystrophy. [PDF]

Invest Ophthalmol Vis Sci
Zhao X, Duan H, Dou S, Li X, Lin Y, Zhao C, Li D, Zhou L, Li Z, Zhou Q.   +9 more
europepmc   +1 more source

Cilia in Nervous System Development, Function, and Disease

MedComm – Future Medicine, Volume 5, Issue 2, June 2026.
Cilia are evolutionarily conserved organelles that function as essential sensory and motility platforms in the nervous system. This review outlines key cilia‐dependent signaling pathways and their roles in neural development and function. Furthermore, it highlights how ciliary dysfunction can lead to a variety of neurological disorders, known as ...
Qingchao Li, Anqi Zhang, Ting Song
wiley   +1 more source

Femto-DSAEK for deep posterior stromal opacity: a lamellar alternative to PK in failed DMEK. [PDF]

Am J Ophthalmol Case Rep
Lucchino L, Romano D, Vaccaro S, Moramarco A, Semeraro F, Fontana L, Romano V.   +6 more
europepmc   +1 more source

Genetic Analysis of Pitt–Hopkins Syndrome Caused by a Novel Splicing Variant (c.1146+3A>T) in the TCF4 Gene

Molecular Genetics &Genomic Medicine, Volume 14, Issue 6, June 2026.
A novel pathogenic splicing variant (TCF4c.1146+3A>T) was identified in a fetus with increased nuchal translucency. The variant disrupts normal splicing, causing exon 14 skipping and protein truncation, which is consistent with Pitt–Hopkins Syndrome.
Wenlong Shen, Yan Zhang, Junjie Wu, Jue Zhao, Yaer Lv, Xiaohua Tang   +5 more
wiley   +1 more source

Protocol for culturing healthy primary endothelial cells isolated from research-grade human corneoscleral donor tissue. [PDF]

STAR Protoc
van der Krogt JMA, Dallinga MG, van den Bogaerdt AJ, van der Meulen IJE, van Buul JD.   +4 more
europepmc   +1 more source

Phenotypic Refinement of ESAM‐Related Tight‐Junctionopathy: Novel Genetic and Ocular Findings and Literature Review

Molecular Genetics &Genomic Medicine, Volume 14, Issue 6, June 2026.
Overview of neurological, ocular, and genetic findings in individuals with bi‐allelic loss‐of‐function (LoF) ESAM variants. All affected subjects (n = 21) exhibited characteristic neurovascular and neurodevelopmental anomalies, while 45% also showed ocular (mainly retinal) involvement.
Mauro Lecca, Chiara Bosetti, Federico Ruoli, Liviana Fontanel, Marco Mazza, Enza Maria Valente, Roberta Battini, Edoardo Errichiello   +7 more
wiley   +1 more source

Cytomegalovirus Infection of the Anterior Segment: Corneal Endotheliitis and Secondary Glaucoma. [PDF]

Pathogens
Liu F, Zou Y, Yang M, Zhang J, Ohno-Matsui K, Kamoi K.   +5 more
europepmc   +1 more source

Smart Polymer‐Based Drug Delivery Systems for Managing Infective Conjunctivitis: Advances and Future Prospects

Nano Select, Volume 7, Issue 6, June 2026.
The introduction covers the background and significance of conjunctivitis. It continues with a review of etiology, epidemiology, and clinical manifestations. Diagnostic methods are described, followed by discussions on pathophysiology and classification. Current treatment strategies, preventive measures, and therapeutic challenges are analyzed.
Xia Linkang, Marwan Abdelmahmoud Abdelkarim Maki, Saad Tayyab, Sachin Thakur, Pankaj Kumar, Ritu Karwasra, Mahesh Harihar Behare, Nitin Sharma, Wan Hamirul Bahrin Wan Kamal, Oganeswary Kobi, Kushagra Khanna, Mogana Rajagopal   +11 more
wiley   +1 more source