Results 121 to 130 of about 266,603 (335)

Misrepair mechanism in the development of atherosclerotic plaques [PDF]

arXiv, 2015
Atherosclerosis is a disease characterized by the development of atherosclerotic plaques (APs) in arterial endothelium. The APs in part of an arterial wall are inhomogeneous on size and on distribution. In order to understand this in-homogeneity, the pathology of APs is analyzed by Misrepair mechanism, a mechanism proposed in our Misrepair-accumulation
arxiv  

Endothelial Cell Dysfunction in Viral Hemorrhage and Edema

Frontiers in Microbiology, 2015
The endothelium maintains a vascular barrier by controlling platelet and immune cell interactions, capillary tone and interendothelial cell adherence.
Erich Reuter Mackow, Elena E Gorbunova, Irina N. Gavrilovskaya   +2 more
doaj   +1 more source

Comparison of the diagnostic accuracy of lymphatic endothelium markers: Bayesian approach [PDF]

Modern Pathology, 2005
Tumor lymphatic density is evaluated by means of specific lymphatic endothelium markers, and is a potential predictor of clinically meaningful outcomes. There are many claims on the postulated superiority of some of these markers to identify lymphatics, always in the absence of quantitative data.
Panayiotis A. Kyzas, Evangelos Evangelou, Thomas A Trikalinos, Thomas A Trikalinos   +3 more
openaire   +4 more sources

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

The Role of the Endothelium in HPS Pathogenesis and Potential Therapeutic Approaches

Advances in Virology, 2012
American hantaviruses cause a highly lethal acute pulmonary edema termed hantavirus pulmonary syndrome (HPS). Hantaviruses nonlytically infect endothelial cells and cause dramatic changes in barrier functions of the endothelium without disrupting the ...
Irina Gavrilovskaya, Elena Gorbunova, Valery Matthys, Nadine Dalrymple, Erich Mackow   +4 more
doaj   +1 more source

Strategies to Design and Optimize Artificial Antigen‐Presenting Cells for T Cell Expansion in Cancer Immunotherapy

Advanced Functional Materials, EarlyView.
This review highlights recent advances in engineering artificial antigen‐presenting cells (aAPCs) as alternatives to dendritic cells for T cell expansion. Key design principles inspired by the immunological synapse are discussed, with emphasis on strategies for polyclonal and antigen‐specific T cell expansion.
Nguyen Thi Nguyen, Yu Seok Youn
wiley   +1 more source

Lymph nodes go with the flow [PDF]

, 2018
In this issue, Bovay et al. (https://doi.org/10.1084/jem.20180217) invoke a compelling model of interplay between the venous and lymphatic vasculature in regulating the developmental genesis and early expansion of LNs.
Czepielewski, Rafael S, Randolph, Gwendalyn J   +1 more
core   +1 more source

Colon cancer cell-derived 12(S)-HETE induces the retraction of cancer-associated fibroblast via MLC2, RHO/ROCK and Ca2+ signalling [PDF]

, 2016
Retraction of mesenchymal stromal cells supports the invasion of colorectal cancer cells (CRC) into the adjacent compartment. CRC-secreted 12(S)-HETE enhances the retraction of cancer-associated fibroblasts (CAFs) and therefore, 12(S)-HETE may enforce ...
Bago-Horvath, Zsuzsanna, Brendel, Konstantin Alexander, Brenner, Stefan, De Wever, Olivier, Dolznig, Helmut, Eichsteininger, Julia, Giessrigl, Benedikt, Holzner, Silvio, Huttary, Nicole, Jäger, Walter, Koperek, Oskar, Krenn, Liselotte, Krieger, Sigurd, Krupitza, Georg, Mader, Robert M, Marian, Brigitte, Milovanovic, Daniela, Nguyen, Chi Huu, Schachner, Helga, Schmidt, Wolfgang M, Senfter, Daniel, Stadler, Mira, Stadler, Serena   +22 more
core   +1 more source

“Therapies Through Gut:” Targeted Drug Delivery for Non‐Gastrointestinal Diseases by Oral Administration

Advanced Healthcare Materials, EarlyView.
Schematic illustration of the mechanism of targeted delivery of nanoparticles including 1) paracellular, 2) endolysosomal escape, 3) receptor mediated endocytosis, and 4) M cell mediated transport for non‐GI diseases by oral administration such as atherosclerosis, cancer, diabetes, and brain diseases. Abstract Oral drug delivery is a promising approach
Subarna Ray, Shehzahdi S. Moonshi, Hang Thu Ta   +2 more
wiley   +1 more source

Spatio-temporal Models of Lymphangiogenesis in Wound Healing [PDF]

arXiv, 2016
Several studies suggest that one possible cause of impaired wound healing is failed or insufficient lymphangiogenesis, that is the formation of new lymphatic capillaries. Although many mathematical models have been developed to describe the formation of blood capillaries (angiogenesis), very few have been proposed for the regeneration of the lymphatic ...
arxiv