Results 51 to 60 of about 272,678 (276)

Direct specification of lymphatic endothelium from mesenchymal progenitors

Nature Cardiovascular Research
During embryogenesis, endothelial cells (ECs) are generally described to arise from a common pool of progenitors termed angioblasts, which diversify through iterative steps of differentiation to form functionally distinct subtypes of ECs.
Irina-Elena Lupu, D. E. Grainger, Nils Kirschnick, Sarah Weischer, Erica Zhao, I. Martinez-Corral, Hans Schoofs, Marie Vanhollebeke, Grace Jones, Jonathan Godwin, Aden Forrow, Ines Lahmann, Paul R Riley, Thomas Zobel, Kari Alitalo, Taija Mäkinen, Friedemann Kiefer, Oliver A. Stone   +17 more
semanticscholar   +1 more source

Epigenetics and immunometabolism in diabetes and aging [PDF]

, 2018
Significance: A strong relationship between hyperglycemia, impaired insulin pathway and cardiovascular disease in type 2 diabetes (T2D) is linked to oxidative stress and inflammation.
Cosentino, Francesco, Guzik, Tomasz J.
core   +2 more sources

Dynamic cytoskeletal regulation of cell shape supports resilience of lymphatic endothelium

Nature
Lymphatic capillaries continuously take up interstitial fluid and adapt to resulting changes in vessel calibre1, 2–3. The mechanisms by which the permeable monolayer of loosely connected lymphatic endothelial cells (LECs)4 maintains mechanical stability ...
Hans Schoofs, N. Daubel, Sarah Schnabellehner, M. L. Grönloh, Sebastián Palacios Martínez, Aleksi Halme, Amanda M Marks, M. Jeansson, Sara Barcos, Cord Brakebusch, Rui Benedito, Britta Engelhardt, Dietmar Vestweber, Konstantin Gaengel, Fabian Linsenmeier, Sebastian Schürmann, P. Saharinen, J. V. van Buul, Oliver Friedrich, Richard S. Smith, Mateusz Majda, Taija Mäkinen   +21 more
semanticscholar   +1 more source

Lymphatic Endothelial-to-Myofibroblast Transition: A Potential New Mechanism Underlying Skin Fibrosis in Systemic Sclerosis

Cells, 2023
At present, only a few reports have addressed the possible contribution of the lymphatic vascular system to the pathogenesis of systemic sclerosis (SSc).
I. Rosa, E. Romano, B. Fioretto, K. El Aoufy, S. Bellando-Randone, M. Matucci-Cerinic, M. Manetti   +6 more
semanticscholar   +1 more source

Quantitative assessment of angiogenesis in murine antigen-induced arthritis by intravital fluorescence microscopy [PDF]

, 2003
Inhibition of angiogenesis might be a therapeutic approach to prevent joint destruction caused by the overgrowing synovial tissue during chronic joint inflammation.
Krombach, F., Landes, J., Messmer, K., Pellengahr, C., Refior, H. J., Schmitt-Sody, M., Veihelmann, A., Zysk, S. P.   +7 more
core   +1 more source

Homodimerization of the Lymph Vessel Endothelial Receptor LYVE-1 through a Redox-labile Disulfide Is Critical for Hyaluronan Binding in Lymphatic Endothelium

Journal of Biological Chemistry, 2016
The lymphatic vessel endothelial receptor LYVE-1 is implicated in the uptake of hyaluronan (HA) and trafficking of leukocytes to draining lymph nodes. Yet LYVE-1 has only weak affinity for hyaluronan and depends on receptor clustering and higher order ...
Suneale Banerji, William I. Lawrance, C. Metcalfe, David C. Briggs, A. Yamauchi, Omer Dushek, P. A. van der Merwe, Anthony J. Day, David G. Jackson   +8 more
semanticscholar   +1 more source

LYVE-1 expression in the endothelium of newly formed vessels of carotid atherosclerotic plaque

Анналы клинической и экспериментальной неврологии, 2020
Introduction.The discovery of specific markers of lymphatic endothelium, including LYVE-1, has led to a much better understanding of the structure and function of the lymphatic system.
Anna N. Evdokimenko, Ksenia N. Kulichenkova, Tatiana S. Gulevskaya   +2 more
doaj   +1 more source

Mapping the developing human cardiac endothelium at single-cell resolution identifies MECOM as a regulator of arteriovenous gene expression

Cardiovascular Research, 2022
Aims Coronary vasculature formation is a critical event during cardiac development, essential for heart function throughout perinatal and adult life. However, current understanding of coronary vascular development has largely been derived from transgenic
I. McCracken, R. Dobie, M. Bennett, Rainha Passi, A. Beqqali, N. Henderson, J. Mountford, P. Riley, C. Ponting, N. Smart, M. Brittan, A. Baker   +11 more
semanticscholar   +1 more source

The ACCEPTance of automation: refining circulating tumor cells enumeration for improved metastatic colorectal cancer prognosis

Molecular Oncology, EarlyView.
This study highlights the potential of automated enumeration using the ACCEPT software to refine circulating tumor cell (CTC) detection in metastatic colorectal cancer (mCRC). The automated method demonstrates improved accuracy and reduced variability compared to the manual approach.
Michela De Meo, Marco Siringo, Alessandro Vici, Ann Zeuner, Orietta Gandini, Paola Gazzaniga, Chiara Nicolazzo   +6 more
wiley   +1 more source

Lymphendothel in terminaler Herzinsuffizienz und nach Herz- und Lungentransplantation [PDF]

, 2017
The lymphatic endothelium is relevant for the pathogenesis of various cardiac and pulmonary diseases. However, the knowledge about the functions and role of lymphatic endothelium in the setting of transplantation is very limited.
Dashkevich, Alexey
core