Results 71 to 80 of about 266,603 (335)

Mapping the developing human cardiac endothelium at single-cell resolution identifies MECOM as a regulator of arteriovenous gene expression

Cardiovascular Research, 2022
Aims Coronary vasculature formation is a critical event during cardiac development, essential for heart function throughout perinatal and adult life. However, current understanding of coronary vascular development has largely been derived from transgenic
I. McCracken, R. Dobie, M. Bennett, Rainha Passi, A. Beqqali, N. Henderson, J. Mountford, P. Riley, C. Ponting, N. Smart, M. Brittan, A. Baker   +11 more
semanticscholar   +1 more source

Lymphatic expression of CLEVER-1 in breast cancer and its relationship with lymph node metastasis [PDF]

, 2011
BACKGROUND Mechanisms regulating breast cancer lymph node metastasis are unclear. Staining of CLEVER-1 (common lymphatic endothelial and vascular endothelial receptor-1) in human breast tumors was used, along with in vitro techniques, to assess ...
Ammar, Aula, Ellis, Ian O., Martin, Stewart G., Mohammed, Rabab A.A., Paish, Emma C., Pepper, Michael, Salmi, Marko   +6 more
core   +3 more sources

Homodimerization of the Lymph Vessel Endothelial Receptor LYVE-1 through a Redox-labile Disulfide Is Critical for Hyaluronan Binding in Lymphatic Endothelium

Journal of Biological Chemistry, 2016
The lymphatic vessel endothelial receptor LYVE-1 is implicated in the uptake of hyaluronan (HA) and trafficking of leukocytes to draining lymph nodes. Yet LYVE-1 has only weak affinity for hyaluronan and depends on receptor clustering and higher order ...
Suneale Banerji, William I. Lawrance, C. Metcalfe, David C. Briggs, A. Yamauchi, Omer Dushek, P. A. van der Merwe, Anthony J. Day, David G. Jackson   +8 more
semanticscholar   +1 more source

VEGFR-3 signaling regulates triglyceride retention and absorption in the intestine [PDF]

, 2018
The lymphatic system transports dietary lipids absorbed and packaged as chylomicrons by enterocytes, for delivery to the bloodstream. Once considered a passive drainage, chylomicron entry into intestinal lymphatic vessels, or lacteals, is now emerging to
Cifarelli, Vincenza, Shew, Trevor, Wolins, Nathan E   +2 more
core   +2 more sources

Histamine as an Endothelium-Derived Relaxing Factor in Aged Mesenteric Lymphatic Vessels.

Lymphatic Research and Biology, 2017
BACKGROUND Knowledge of the mechanisms by which aging affects contracting lymphatic vessels remains incomplete; therefore, the functional role of histamine in the reaction of aged lymphatic vessels to increases in flow remains unknown.
I. Nizamutdinova, Daisuke Maejima, T. Nagai, C. Meininger, A. Gashev   +4 more
semanticscholar   +1 more source

Balance of Mechanical Forces Drives Endothelial Gap Formation and May Facilitate Cancer and Immune-Cell Extravasation [PDF]

, 2018
The formation of gaps in the endothelium is a crucial process underlying both cancer and immune cell extravasation, contributing to the functioning of the immune system during infection, the unfavorable development of chronic inflammation and tumor metastasis.
arxiv   +1 more source

Elevated expression of the chemokine-scavenging receptor D6 is associated with impaired lesion development in psoriasis [PDF]

, 2012
D6 is a scavenging-receptor for inflammatory CC chemokines that are essential for resolution of inflammatory responses in mice. Here, we demonstrate that D6 plays a central role in controlling cutaneous inflammation, and that D6 deficiency is associated ...
Anne Thorrat, Antal Rot, Codullo, David Burden, Fra, Gerard J. Graham, Graham, Gudjonsson, Helen Baldwin, Homey, Iain B. McInnes, Jamieson, Johnston, Jose M. Carballido, Kave Shams, Kenneth Pallas, Kit Ming Lee, Madigan, Mantovani, Mark D. Singh, Martinez de la Torre, Martinez de la Torre, McKimmie, Nestle, Nibbs, Nibbs, Nibbs, Nickoloff, Nickoloff, Rot, Ruairidh Nicoll, Ruchatz, Susan Holmes, Thomas Jamieson, van de Kerkhof, Vetrano, Vicky King, Weber, Whitehead, Yoshinaga   +39 more
core   +1 more source

LYVE-1 expression in the endothelium of newly formed vessels of carotid atherosclerotic plaque

Анналы клинической и экспериментальной неврологии, 2020
Introduction.The discovery of specific markers of lymphatic endothelium, including LYVE-1, has led to a much better understanding of the structure and function of the lymphatic system.
Anna N. Evdokimenko, Ksenia N. Kulichenkova, Tatiana S. Gulevskaya   +2 more
doaj   +1 more source

KATP channels in Lymphatic Function.

American Journal of Physiology - Cell Physiology, 2022
KATP channels function as negative regulators of active lymphatic pumping and lymph transport. This review summarizes and critiques the evidence for the expression of specific KATP channel subunits in lymphatic smooth muscle and endothelium, the roles ...
M. Davis, H. Kim, C. Nichols
semanticscholar   +1 more source

Lymphendothel in terminaler Herzinsuffizienz und nach Herz- und Lungentransplantation [PDF]

, 2017
The lymphatic endothelium is relevant for the pathogenesis of various cardiac and pulmonary diseases. However, the knowledge about the functions and role of lymphatic endothelium in the setting of transplantation is very limited.
Dashkevich, Alexey
core