Effects of Endotoxemia and Blood Pressure on Microcirculation and Noradrenaline Needs With or Without Dexmedetomidine in Beagle Dogs—A Blinded Cross-Over Study [PDF]
AnimalsEndotoxemia often leads to microcirculatory derangement. In six sevoflurane anaesthetized Beagle dogs, we investigated the effects of 1 mg/kg of Escherichia coli lipopolysaccharide endotoxin intravenous and blood pressure (mean arterial pressure of 65 ...
Barbara Steblaj +4 more
doaj +2 more sources
Unraveling the Role of Metabolic Endotoxemia in Accelerating Breast Tumor Progression [PDF]
BiomedicinesBackground: Obese women have a significantly higher risk of bearing breast tumors that are resistant to therapies and are associated with poorer prognoses/treatment outcomes.
Daniela Nahmias Blank +8 more
doaj +2 more sources
Hematologic Ratios in Donkeys: Reference Intervals and Response to Experimentally Induced Endotoxemia [PDF]
AnimalsEndotoxemia is commonly observed in donkeys, secondary to colic, pleuropneumonia, or diarrhea among other disorders. Hematologic ratios are new biomarkers widely used in the diagnosis and prognosis of multiple conditions in human medicine, including ...
Carmen Davias +5 more
doaj +2 more sources
TLR4 and prostaglandin pathways at the crossroads of endotoxemia-induced lipolysis [PDF]
Frontiers in ImmunologyBackgroundDuring endotoxemia, immune activation rapidly increases energy needs. To meet these demands, white adipose tissue (WAT) mobilizes fatty acids through lipolysis. While fatty acids serve as energy-dense substrates, they also act as precursors for
Miguel Chirivi +6 more
doaj +2 more sources
Hepatic Nuclear Factor Erythroid 2 Related Factor 1 Activity Promotes Host Defense in Endotoxemia and Bacterial SepsisSummary [PDF]
Cellular and Molecular Gastroenterology and HepatologyBackground & Aims: Sepsis and endotoxemia cause mortality by inducing organ dysfunction and damage. Liver defends against such insults by mediating metabolic adaptations that promote stress and damage control. The mechanisms underlying liver defenses
Michael J. Trites +5 more
doaj +2 more sources
Dynamics of oxylipin biosynthesis in systemic inflammation: insights from a large animal model of endotoxemia [PDF]
Frontiers in ImmunologyIntroductionEndotoxemia, marked by the presence of bacterial lipopolysaccharide (LPS) in the bloodstream, induces acute inflammation and is implicated in both mortality and chronic disease across species.
Madison N. Myers +6 more
doaj +2 more sources
Sex-differences in endotoxemia and trimethylamine N-oxide according to the diet and type 2 diabetes status in coronary heart disease patients: from the CORDIOPREV study [PDF]
Frontiers in Cardiovascular MedicineBackgroundCardiovascular disease (CVD) develops in men earlier in life but CVD women have a higher risk of cardiovascular mortality than CVD men. In addition, co-occurrence with type 2 diabetes mellitus (T2DM) increases CVD risk. We aimed to evaluate sex
Helena Garcia-Fernandez +46 more
doaj +2 more sources
JQ1 as a BRD4 Inhibitor Blocks Inflammatory Pyroptosis-Related Acute Colon Injury Induced by LPS
Frontiers in Immunology, 2021 Endotoxemia is a severe inflammation response induced by infection especially bacterial endotoxin translocation, which severely increases mortality in combination with acute colon injury.
Ling Chen +11 more
doaj +1 more source
Anti-Apoptotic Role of Sanhuang Xiexin Decoction and Anisodamine in Endotoxemia
Frontiers in Pharmacology, 2021 Endotoxemia is characterized by initial uncontrollable inflammation, terminal immune paralysis, significant cell apoptosis and tissue injury, which can aggravate or induce multiple diseases and become one of the complications of many diseases. Therefore,
Zixuan Liu +14 more
doaj +1 more source
Genetic Profile of Endotoxemia Reveals an Association With Thromboembolism and Stroke
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021 Background Translocation of lipopolysaccharide from gram‐negative bacteria into the systemic circulation results in endotoxemia. In addition to acute infections, endotoxemia is detected in cardiometabolic disorders, such as cardiovascular diseases and ...
Jaakko Leskelä +22 more
doaj +1 more source